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Q1DFW5

- FTHS_MYXXD

UniProt

Q1DFW5 - FTHS_MYXXD

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, MXAN_0175
Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 618ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMXAN246197:GIWU-171-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:MXAN_0175
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
ProteomesiUP000002402: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000293048Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_0175.

Structurei

3D structure databases

ProteinModelPortaliQ1DFW5.
SMRiQ1DFW5. Positions 2-546.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1DFW5-1 [UniParc]FASTAAdd to Basket

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MTLRAMTDVG AELGLSPEDV LPWGTHRAKV SLDALGKRGG RQGRLVLVSA    50
INPTPPGEGK TTMSVALAMG LRKRGRRAVA ALREPSLGPV FGVKGGGTGG 100
GQASLEPAAD INLHFTGDLH AITSANNLLS ALVDNAVFYG QPVALDATRV 150
RWRRALDMND RFLRNVIVGL GGKAQGVPRE DHFDITAASE VMAILALAEG 200
LKDLEARLGR VIIGHTRDGQ PVRARDVDAA ASMVALLKDA LMPNLAQTRE 250
GGPALVHAGP FANIAHGCSS VMGTRMGLAY ADEVITEAGF GFDLGAEKFL 300
DIKCRGSGLW PRGVVLVVTL RALKHHGGAS PARVAEPDRE ALVRGFAHLE 350
KHLESVAAFG LPAVLCVNRF PQDTESELEE LRAFGKARGV ETAVCDGFSR 400
GGDGSLELAD CVLEMLDGTD AAPPQPRFLY DVAQTPEEKV AAIARTVYGA 450
DDVAFTASAK KDLDAIRELG GAGLPVCMAK THLSLSDDPT KLGRPRGFTL 500
TVREVRLSAG AGFMVALTGE ILTMPGLPRE PAARRVTVHD DGRVTGLMQG 550
E 551
Length:551
Mass (Da):58,072
Last modified:July 11, 2006 - v1
Checksum:i67F9271C23228902
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000113 Genomic DNA. Translation: ABF87836.1.
RefSeqiYP_628458.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF87836; ABF87836; MXAN_0175.
GeneIDi4101290.
KEGGimxa:MXAN_0175.
PATRICi22642931. VBIMyxXan43560_0179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000113 Genomic DNA. Translation: ABF87836.1 .
RefSeqi YP_628458.1. NC_008095.1.

3D structure databases

ProteinModelPortali Q1DFW5.
SMRi Q1DFW5. Positions 2-546.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246197.MXAN_0175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF87836 ; ABF87836 ; MXAN_0175 .
GeneIDi 4101290.
KEGGi mxa:MXAN_0175.
PATRICi 22642931. VBIMyxXan43560_0179.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MXAN246197:GIWU-171-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DK 1622.

Entry informationi

Entry nameiFTHS_MYXXD
AccessioniPrimary (citable) accession number: Q1DFW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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