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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi54 – 61ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-172-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:MXAN_0175
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002930481 – 551Formate--tetrahydrofolate ligaseAdd BLAST551

Proteomic databases

PRIDEiQ1DFW5

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_0175

Structurei

3D structure databases

ProteinModelPortaliQ1DFW5
SMRiQ1DFW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1DFW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRAMTDVG AELGLSPEDV LPWGTHRAKV SLDALGKRGG RQGRLVLVSA
60 70 80 90 100
INPTPPGEGK TTMSVALAMG LRKRGRRAVA ALREPSLGPV FGVKGGGTGG
110 120 130 140 150
GQASLEPAAD INLHFTGDLH AITSANNLLS ALVDNAVFYG QPVALDATRV
160 170 180 190 200
RWRRALDMND RFLRNVIVGL GGKAQGVPRE DHFDITAASE VMAILALAEG
210 220 230 240 250
LKDLEARLGR VIIGHTRDGQ PVRARDVDAA ASMVALLKDA LMPNLAQTRE
260 270 280 290 300
GGPALVHAGP FANIAHGCSS VMGTRMGLAY ADEVITEAGF GFDLGAEKFL
310 320 330 340 350
DIKCRGSGLW PRGVVLVVTL RALKHHGGAS PARVAEPDRE ALVRGFAHLE
360 370 380 390 400
KHLESVAAFG LPAVLCVNRF PQDTESELEE LRAFGKARGV ETAVCDGFSR
410 420 430 440 450
GGDGSLELAD CVLEMLDGTD AAPPQPRFLY DVAQTPEEKV AAIARTVYGA
460 470 480 490 500
DDVAFTASAK KDLDAIRELG GAGLPVCMAK THLSLSDDPT KLGRPRGFTL
510 520 530 540 550
TVREVRLSAG AGFMVALTGE ILTMPGLPRE PAARRVTVHD DGRVTGLMQG

E
Length:551
Mass (Da):58,072
Last modified:July 11, 2006 - v1
Checksum:i67F9271C23228902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA Translation: ABF87836.1
RefSeqiWP_011550322.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF87836; ABF87836; MXAN_0175
KEGGimxa:MXAN_0175

Similar proteinsi

Entry informationi

Entry nameiFTHS_MYXXD
AccessioniPrimary (citable) accession number: Q1DFW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health