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Q1DFW5 (FTHS_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:MXAN_0175
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293048

Regions

Nucleotide binding54 – 618ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1DFW5 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 67F9271C23228902

FASTA55158,072
        10         20         30         40         50         60 
MTLRAMTDVG AELGLSPEDV LPWGTHRAKV SLDALGKRGG RQGRLVLVSA INPTPPGEGK 

        70         80         90        100        110        120 
TTMSVALAMG LRKRGRRAVA ALREPSLGPV FGVKGGGTGG GQASLEPAAD INLHFTGDLH 

       130        140        150        160        170        180 
AITSANNLLS ALVDNAVFYG QPVALDATRV RWRRALDMND RFLRNVIVGL GGKAQGVPRE 

       190        200        210        220        230        240 
DHFDITAASE VMAILALAEG LKDLEARLGR VIIGHTRDGQ PVRARDVDAA ASMVALLKDA 

       250        260        270        280        290        300 
LMPNLAQTRE GGPALVHAGP FANIAHGCSS VMGTRMGLAY ADEVITEAGF GFDLGAEKFL 

       310        320        330        340        350        360 
DIKCRGSGLW PRGVVLVVTL RALKHHGGAS PARVAEPDRE ALVRGFAHLE KHLESVAAFG 

       370        380        390        400        410        420 
LPAVLCVNRF PQDTESELEE LRAFGKARGV ETAVCDGFSR GGDGSLELAD CVLEMLDGTD 

       430        440        450        460        470        480 
AAPPQPRFLY DVAQTPEEKV AAIARTVYGA DDVAFTASAK KDLDAIRELG GAGLPVCMAK 

       490        500        510        520        530        540 
THLSLSDDPT KLGRPRGFTL TVREVRLSAG AGFMVALTGE ILTMPGLPRE PAARRVTVHD 

       550 
DGRVTGLMQG E 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000113 Genomic DNA. Translation: ABF87836.1.
RefSeqYP_628458.1. NC_008095.1.

3D structure databases

ProteinModelPortalQ1DFW5.
SMRQ1DFW5. Positions 2-546.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246197.MXAN_0175.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF87836; ABF87836; MXAN_0175.
GeneID4101290.
KEGGmxa:MXAN_0175.
PATRIC22642931. VBIMyxXan43560_0179.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-171-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_MYXXD
AccessionPrimary (citable) accession number: Q1DFW5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways