Q1DFW5 (FTHS_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	MXAN_0175

Organism

Myxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]

Taxonomic identifier

246197 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus › Myxococcus xanthus

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543		PRO_0000293048
Regions
	Nucleotide binding	54 – 61	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1DFW5 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 67F9271C23228902	FASTA	551	58,072
	10 20 30 40 50 60 MTLRAMTDVG AELGLSPEDV LPWGTHRAKV SLDALGKRGG RQGRLVLVSA INPTPPGEGK 70 80 90 100 110 120 TTMSVALAMG LRKRGRRAVA ALREPSLGPV FGVKGGGTGG GQASLEPAAD INLHFTGDLH 130 140 150 160 170 180 AITSANNLLS ALVDNAVFYG QPVALDATRV RWRRALDMND RFLRNVIVGL GGKAQGVPRE 190 200 210 220 230 240 DHFDITAASE VMAILALAEG LKDLEARLGR VIIGHTRDGQ PVRARDVDAA ASMVALLKDA 250 260 270 280 290 300 LMPNLAQTRE GGPALVHAGP FANIAHGCSS VMGTRMGLAY ADEVITEAGF GFDLGAEKFL 310 320 330 340 350 360 DIKCRGSGLW PRGVVLVVTL RALKHHGGAS PARVAEPDRE ALVRGFAHLE KHLESVAAFG 370 380 390 400 410 420 LPAVLCVNRF PQDTESELEE LRAFGKARGV ETAVCDGFSR GGDGSLELAD CVLEMLDGTD 430 440 450 460 470 480 AAPPQPRFLY DVAQTPEEKV AAIARTVYGA DDVAFTASAK KDLDAIRELG GAGLPVCMAK 490 500 510 520 530 540 THLSLSDDPT KLGRPRGFTL TVREVRLSAG AGFMVALTGE ILTMPGLPRE PAARRVTVHD 550 DGRVTGLMQG E

References

[1]

"Evolution of sensory complexity recorded in a myxobacterial genome." Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B. Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DK 1622.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000113 Genomic DNA. Translation: ABF87836.1.
RefSeq	YP_628458.1. NC_008095.1.
3D structure databases
ProteinModelPortal	Q1DFW5.
SMR	Q1DFW5. Positions 2-546.
ModBase	Search...
Protein-protein interaction databases
STRING	246197.MXAN_0175.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF87836; ABF87836; MXAN_0175.
GeneID	4101290.
KEGG	mxa:MXAN_0175.
PATRIC	22642931. VBIMyxXan43560_0179.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HOG000040280.
KO	K01938.
OMA	EIMAVLC.
Enzyme and pathway databases
BioCyc	MXAN246197:GIWU-171-MONOMER.
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. False negative. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_MYXXD

Accession

Primary (citable) accession number: Q1DFW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program