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Q1DFW5

- FTHS_MYXXD

UniProt

Q1DFW5 - FTHS_MYXXD

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi54 – 618ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMXAN246197:GIWU-171-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:MXAN_0175
    OrganismiMyxococcus xanthus (strain DK 1622)
    Taxonomic identifieri246197 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
    ProteomesiUP000002402: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Formate--tetrahydrofolate ligasePRO_0000293048Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246197.MXAN_0175.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1DFW5.
    SMRiQ1DFW5. Positions 2-546.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1DFW5-1 [UniParc]FASTAAdd to Basket

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    MTLRAMTDVG AELGLSPEDV LPWGTHRAKV SLDALGKRGG RQGRLVLVSA    50
    INPTPPGEGK TTMSVALAMG LRKRGRRAVA ALREPSLGPV FGVKGGGTGG 100
    GQASLEPAAD INLHFTGDLH AITSANNLLS ALVDNAVFYG QPVALDATRV 150
    RWRRALDMND RFLRNVIVGL GGKAQGVPRE DHFDITAASE VMAILALAEG 200
    LKDLEARLGR VIIGHTRDGQ PVRARDVDAA ASMVALLKDA LMPNLAQTRE 250
    GGPALVHAGP FANIAHGCSS VMGTRMGLAY ADEVITEAGF GFDLGAEKFL 300
    DIKCRGSGLW PRGVVLVVTL RALKHHGGAS PARVAEPDRE ALVRGFAHLE 350
    KHLESVAAFG LPAVLCVNRF PQDTESELEE LRAFGKARGV ETAVCDGFSR 400
    GGDGSLELAD CVLEMLDGTD AAPPQPRFLY DVAQTPEEKV AAIARTVYGA 450
    DDVAFTASAK KDLDAIRELG GAGLPVCMAK THLSLSDDPT KLGRPRGFTL 500
    TVREVRLSAG AGFMVALTGE ILTMPGLPRE PAARRVTVHD DGRVTGLMQG 550
    E 551
    Length:551
    Mass (Da):58,072
    Last modified:July 11, 2006 - v1
    Checksum:i67F9271C23228902
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000113 Genomic DNA. Translation: ABF87836.1.
    RefSeqiYP_628458.1. NC_008095.1.

    Genome annotation databases

    EnsemblBacteriaiABF87836; ABF87836; MXAN_0175.
    GeneIDi4101290.
    KEGGimxa:MXAN_0175.
    PATRICi22642931. VBIMyxXan43560_0179.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000113 Genomic DNA. Translation: ABF87836.1 .
    RefSeqi YP_628458.1. NC_008095.1.

    3D structure databases

    ProteinModelPortali Q1DFW5.
    SMRi Q1DFW5. Positions 2-546.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246197.MXAN_0175.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF87836 ; ABF87836 ; MXAN_0175 .
    GeneIDi 4101290.
    KEGGi mxa:MXAN_0175.
    PATRICi 22642931. VBIMyxXan43560_0179.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MXAN246197:GIWU-171-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DK 1622.

    Entry informationi

    Entry nameiFTHS_MYXXD
    AccessioniPrimary (citable) accession number: Q1DFW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3