Q1DDU6 (KMO_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	MXAN_0916

Organism

Myxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]

Taxonomic identifier

246197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 464	464	Kynurenine 3-monooxygenase		PRO_0000361941

Sequences

	Sequence		Length	Mass (Da)
	Q1DDU6 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: F89635B2099C96B9	FASTA	464	50,920
	10 20 30 40 50 60 MSEARKDTVT VVGAGLVGSL LSIYLARRGH TVELLERRPD MRRETVDGGR SINLAISTRG 70 80 90 100 110 120 LHALRQVGLE NEALKHAIPM RGRMIHPPQG ELVYQPYGKD DSQHINAMSR GWLNAFLMTA 130 140 150 160 170 180 AEATGKVRIR FKQRVTDVDF GSGALTVHDD ATGEARQEPG RVVFGTDGSA SAIRQALEKR 190 200 210 220 230 240 PDFKGTQEQL GHGYKELTIP AGPGGAFQME KHALHIWPRG TFMLIALPDE EGSFTCTLFL 250 260 270 280 290 300 PWQGPVSFAS LDTPAKLEAF FGAQFPDAKA LIPDLVEAFF SRPTGSMVTV KGAPWHAGGQ 310 320 330 340 350 360 TLLLGDAAHA IVPFFGQGMN CGFEDCVVLD QLLGQGAGWE QVFTDFERLR KTNADAIADM 370 380 390 400 410 420 AVENFVEMRD STGDPRFLFR KAVEKVLLNA FPGEFVSRYS LVSFSHVPYR LAYQMGALTD 430 440 450 460 GIVSELSEGL PRAEDVDLKR AAELIRSRLT PFMKEHADGF RTEG

References

[1]

"Evolution of sensory complexity recorded in a myxobacterial genome." Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B. Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed: 17015832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DK 1622.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000113 Genomic DNA. Translation: ABF90126.1.
RefSeq	YP_629177.1. NC_008095.1.
3D structure databases
ProteinModelPortal	Q1DDU6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1DDU6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4103649.
GenomeReviews	Gene locus MXAN_0916 in contig CP000113_GR.
KEGG	mxa:MXAN_0916.
PATRIC	22644407. VBIMyxXan43560_0906.
TIGR	MXAN_0916.
Phylogenomic databases
eggNOG	COG0654.
HOGENOM	HBG430104.
OMA	YFPDAIP.
PhylomeDB	Q1DDU6.
ProtClustDB	CLSK903475.
Enzyme and pathway databases
BioCyc	MXAN246197:MXAN_0916-MONOMER.
Family and domain databases
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
KO	K00486.
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_MYXXD

Accession

Primary (citable) accession number: Q1DDU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program