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Q1DDU5 (KYNU_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynureninase

EC=3.7.1.3
Alternative name(s):
L-kynurenine hydrolase
Gene names
Name:kynU
Ordered Locus Names:MXAN_0917
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. HAMAP-Rule MF_01970

Catalytic activity

L-kynurenine + H2O = anthranilate + L-alanine. HAMAP-Rule MF_01970

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. HAMAP-Rule MF_01970

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01970

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. HAMAP-Rule MF_01970

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. HAMAP-Rule MF_01970

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01970

Sequence similarities

Belongs to the kynureninase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Kynureninase HAMAP-Rule MF_01970
PRO_0000357009

Regions

Region138 – 1414Pyridoxal phosphate binding By similarity

Sites

Binding site1101Pyridoxal phosphate; via amide nitrogen By similarity
Binding site1111Pyridoxal phosphate By similarity
Binding site2231Pyridoxal phosphate By similarity
Binding site2261Pyridoxal phosphate By similarity
Binding site2481Pyridoxal phosphate By similarity
Binding site2791Pyridoxal phosphate By similarity
Binding site3071Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2491N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1DDU5 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 9F8B6DCA33680072

FASTA42647,760
        10         20         30         40         50         60 
MTTPYLFEDS ESFARKLDAE DALRGYRDAF HFPPGPDGKP VVYLAGNSLG LQPRNAARYI 

        70         80         90        100        110        120 
QEELEDWARL GVEGHHHGRH PWLHYHELVT EHAARLVGAK PLEVVVMNTL SVNLHLMMVS 

       130        140        150        160        170        180 
FYRPTKQRFK ILVEAGAFPS DQYAVASQVR FHGYDAREAV LELKPREGEE TLRTEDILET 

       190        200        210        220        230        240 
IERHGHEVAL VMLGSVNYLT GQAFDLAAIT KAAHAKGCFV GFDLAHGAGN LRLSLHDDGP 

       250        260        270        280        290        300 
DFAVWCSYKY LNAGPGALGG VFVHERHAHT KDLPRFEGWW GHDKQTRFQM GPTFSALPGA 

       310        320        330        340        350        360 
EGWQLSNPPI FQLAALRASL ELFDQAGMAA LRAKSERLTG YLEFLLDRLP EGFVRITTPR 

       370        380        390        400        410        420 
DVKQRGAQLS LRFRGEPQGL LKRLGDAGII CDFRKPDIIR AAPAPLYNSF TDVYRFVKTL 


EGHARE 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000113 Genomic DNA. Translation: ABF87345.1.
RefSeqYP_629178.1. NC_008095.1.

3D structure databases

ProteinModelPortalQ1DDU5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246197.MXAN_0917.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF87345; ABF87345; MXAN_0917.
GeneID4104929.
KEGGmxa:MXAN_0917.
PATRIC22644409. VBIMyxXan43560_0907.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHOG000242438.
KOK01556.
OMAVWDLAHS.
OrthoDBEOG6N67XP.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-905-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01970. Kynureninase.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKYNU_MYXXD
AccessionPrimary (citable) accession number: Q1DDU5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways