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Protein

8-amino-7-oxononanoate synthase

Gene

bioF

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.UniRule annotation

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25SubstrateUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Binding sitei183Pyridoxal phosphateUniRule annotation1
Binding sitei211Pyridoxal phosphateUniRule annotation1
Binding sitei239Pyridoxal phosphateUniRule annotation1
Binding sitei355SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00078.

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthaseUniRule annotation (EC:2.3.1.47UniRule annotation)
Short name:
AONSUniRule annotation
Alternative name(s):
7-keto-8-amino-pelargonic acid synthaseUniRule annotation
Short name:
7-KAP synthaseUniRule annotation
Short name:
KAPA synthaseUniRule annotation
8-amino-7-ketopelargonate synthaseUniRule annotation
Gene namesi
Name:bioFUniRule annotation
Ordered Locus Names:MXAN_1258
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003810471 – 3918-amino-7-oxononanoate synthaseAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi246197.MXAN_1258.

Structurei

3D structure databases

ProteinModelPortaliQ1DCV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni112 – 113Pyridoxal phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221021.
KOiK00652.
OMAiELAHACI.
OrthoDBiPOG091H024U.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01693. BioF_aminotrans_2. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR004723. AONS_Archaea/Proteobacteria.
IPR022834. AONS_Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1DCV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEAVAAAW AREDLEALSE RGLRRYLEPL DSPQGPVVRV GGETLVNFSS
60 70 80 90 100
NDYLGLAASP TVRAAALAAV ERYGVGTGAS RLVVGDTAAH HRLETRLAAF
110 120 130 140 150
ERAEAVRLFN SGYAANTGII PALVGSEDAV FSDALNHASL VDGCRLSRAR
160 170 180 190 200
VCVYPHADVE ALTRALAETP ARRKLVVTDT VFSMDGDVAP LRDIVAACRA
210 220 230 240 250
HGAALMVDEA HATGVLGARG AGLCDELGLE SEVDLRMGTL SKALGVMGAY
260 270 280 290 300
VATSREVADL LVSRARPFVF STALPAHLCA AAEAAVDAVE GDPDLRERLW
310 320 330 340 350
RNIRRFADGL RGLGVRAEPR SAVFPLILGE PERALDAARR LREAGVLVKA
360 370 380 390
IRPPTVPEGT SRLRFCLSAS HTVGHVDLAL EALRSVGVRR G
Length:391
Mass (Da):41,405
Last modified:July 11, 2006 - v1
Checksum:i5F7B3E6E69944519
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA. Translation: ABF88105.1.
RefSeqiWP_011551375.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF88105; ABF88105; MXAN_1258.
KEGGimxa:MXAN_1258.
PATRICi22645097. VBIMyxXan43560_1251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA. Translation: ABF88105.1.
RefSeqiWP_011551375.1. NC_008095.1.

3D structure databases

ProteinModelPortaliQ1DCV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246197.MXAN_1258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF88105; ABF88105; MXAN_1258.
KEGGimxa:MXAN_1258.
PATRICi22645097. VBIMyxXan43560_1251.

Phylogenomic databases

eggNOGiENOG4107EEK. Bacteria.
COG0156. LUCA.
HOGENOMiHOG000221021.
KOiK00652.
OMAiELAHACI.
OrthoDBiPOG091H024U.

Enzyme and pathway databases

UniPathwayiUPA00078.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01693. BioF_aminotrans_2. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR004723. AONS_Archaea/Proteobacteria.
IPR022834. AONS_Proteobacteria.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00858. bioF. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIOF_MYXXD
AccessioniPrimary (citable) accession number: Q1DCV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 11, 2006
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.