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Protein

8-amino-7-oxononanoate synthase

Gene

bioF

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.UniRule annotation

Catalytic activityi

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein].UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: biotin biosynthesis

This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway biotin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25SubstrateUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Binding sitei183Pyridoxal phosphateUniRule annotation1
Binding sitei211Pyridoxal phosphateUniRule annotation1
Binding sitei239Pyridoxal phosphateUniRule annotation1
Binding sitei355SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processBiotin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-1228-MONOMER
UniPathwayiUPA00078

Names & Taxonomyi

Protein namesi
Recommended name:
8-amino-7-oxononanoate synthaseUniRule annotation (EC:2.3.1.47UniRule annotation)
Short name:
AONSUniRule annotation
Alternative name(s):
7-keto-8-amino-pelargonic acid synthaseUniRule annotation
Short name:
7-KAP synthaseUniRule annotation
Short name:
KAPA synthaseUniRule annotation
8-amino-7-ketopelargonate synthaseUniRule annotation
Gene namesi
Name:bioFUniRule annotation
Ordered Locus Names:MXAN_1258
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003810471 – 3918-amino-7-oxononanoate synthaseAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi246197.MXAN_1258

Structurei

3D structure databases

ProteinModelPortaliQ1DCV8
SMRiQ1DCV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni112 – 113Pyridoxal phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107EEK Bacteria
COG0156 LUCA
HOGENOMiHOG000221021
KOiK00652
OMAiIDDAHAV
OrthoDBiPOG091H024U

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01693 BioF_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR004723 AONS_Archaea/Proteobacteria
IPR022834 AONS_Proteobacteria
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00858 bioF, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1DCV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEAVAAAW AREDLEALSE RGLRRYLEPL DSPQGPVVRV GGETLVNFSS
60 70 80 90 100
NDYLGLAASP TVRAAALAAV ERYGVGTGAS RLVVGDTAAH HRLETRLAAF
110 120 130 140 150
ERAEAVRLFN SGYAANTGII PALVGSEDAV FSDALNHASL VDGCRLSRAR
160 170 180 190 200
VCVYPHADVE ALTRALAETP ARRKLVVTDT VFSMDGDVAP LRDIVAACRA
210 220 230 240 250
HGAALMVDEA HATGVLGARG AGLCDELGLE SEVDLRMGTL SKALGVMGAY
260 270 280 290 300
VATSREVADL LVSRARPFVF STALPAHLCA AAEAAVDAVE GDPDLRERLW
310 320 330 340 350
RNIRRFADGL RGLGVRAEPR SAVFPLILGE PERALDAARR LREAGVLVKA
360 370 380 390
IRPPTVPEGT SRLRFCLSAS HTVGHVDLAL EALRSVGVRR G
Length:391
Mass (Da):41,405
Last modified:July 11, 2006 - v1
Checksum:i5F7B3E6E69944519
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA Translation: ABF88105.1
RefSeqiWP_011551375.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF88105; ABF88105; MXAN_1258
KEGGimxa:MXAN_1258

Similar proteinsi

Entry informationi

Entry nameiBIOF_MYXXD
AccessioniPrimary (citable) accession number: Q1DCV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health