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Q1DB00

- MASK_MYXXD

UniProt

Q1DB00 - MASK_MYXXD

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Protein
Tyrosine-protein kinase MasK
Gene
masK, MXAN_1929
Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for growth. Interacts with MglA to control social gliding motility.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571ATP By similarity
Active sitei163 – 1631Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMXAN246197:GIWU-1911-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase MasK (EC:2.7.10.2)
Gene namesi
Name:masK
Ordered Locus Names:MXAN_1929
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
ProteomesiUP000002402: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 415415Periplasmic Reviewed prediction
Add
BLAST
Transmembranei416 – 43318Helical; Reviewed prediction
Add
BLAST
Topological domaini434 – 646213Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 646646Tyrosine-protein kinase MasK
PRO_0000282835Add
BLAST

Post-translational modificationi

Autophosphorylated By similarity.

Interactioni

Subunit structurei

Interacts with MglA.1 Publication

Protein-protein interaction databases

STRINGi246197.MXAN_1929.

Structurei

3D structure databases

ProteinModelPortaliQ1DB00.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 300276Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi456 – 53984Ala-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
KOiK08884.
OMAiICMEYLA.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1DB00-1 [UniParc]FASTAAdd to Basket

« Hide

MSPPQTTLPV TEAGLVPLLQ PYGPYVLVRK LAEGGMAEIF LAKLLGADGF    50
ERNVVIKRML PHLTNNPDFV EMFRDEARLA AKLAHPNIVQ IQELGFAEGC 100
YYICMEYLAG EDFSTTLRLA GRKRHYVPLP VVLRVLIDAA RGLHFAHEFT 150
NEAGQPLNVV HRDISPSNLY LTYQGQVKVL DFGIAKAESR LVNTRTGVVK 200
GKYMYMAPEQ ARGKEVDRRA DIFALGVSLY EALTHVRPFS RENDLAVLNA 250
LLQGELKPPR ELRPDLPEEL EAILLKAMAF KPEDRYPTAE AFADALETFL 300
SEHLSGSGAM PLGAFLKGHF GEERFTERSR IPTLATLTAT YGGAAAGAQG 350
QAPGAEPHGT NLYGVLAREG DATSAQRPGM SMRPSSPGVP AHGAASRGST 400
SPESAPTAGG RRWRTLAVGL AGGLMLAAAG IVGYRQWMTT PASVSLVPAT 450
VPVVEAVAPE AAAAQVGAPM EAVAPVGAAA QAGSLTDAVA NGAGGDVGET 500
DSAQLSVDAA GVTETDEAGL AGAASDVEAE ADEEGADAAP VRSKKASSQK 550
RVTLGIDDVQ RVVSRGRARI TTCFERYKAD LPSSQGEVQV QLTIVSSGKV 600
RAGTRGPLAS SGVGRCLEAQ AERLRFPPHR DQEVTVVMPF SWRVTQ 646
Length:646
Mass (Da):68,576
Last modified:July 11, 2006 - v1
Checksum:iC9667634284FE40C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF377950 Genomic DNA. Translation: AAK54653.1.
CP000113 Genomic DNA. Translation: ABF90801.1.
RefSeqiWP_011552028.1. NC_008095.1.
YP_630173.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF90801; ABF90801; MXAN_1929.
GeneIDi4105479.
KEGGimxa:MXAN_1929.
PATRICi22646407. VBIMyxXan43560_1900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF377950 Genomic DNA. Translation: AAK54653.1 .
CP000113 Genomic DNA. Translation: ABF90801.1 .
RefSeqi WP_011552028.1. NC_008095.1.
YP_630173.1. NC_008095.1.

3D structure databases

ProteinModelPortali Q1DB00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246197.MXAN_1929.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF90801 ; ABF90801 ; MXAN_1929 .
GeneIDi 4105479.
KEGGi mxa:MXAN_1929.
PATRICi 22646407. VBIMyxXan43560_1900.

Phylogenomic databases

eggNOGi COG0515.
KOi K08884.
OMAi ICMEYLA.
OrthoDBi EOG6B35XT.

Enzyme and pathway databases

BioCyci MXAN246197:GIWU-1911-MONOMER.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gliding motility in Myxococcus xanthus: mgl locus, RNA, and predicted protein products."
    Stephens K., Hartzell P.L., Kaiser D.
    J. Bacteriol. 171:819-830(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DK 1622.
  3. "MglA, a small GTPase, interacts with a tyrosine kinase to control type IV pili-mediated motility and development of Myxococcus xanthus."
    Thomasson B., Link J., Stassinopoulos A.G., Burke N., Plamann L., Hartzell P.L.
    Mol. Microbiol. 46:1399-1413(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, INTERACTION WITH MGLA.

Entry informationi

Entry nameiMASK_MYXXD
AccessioniPrimary (citable) accession number: Q1DB00
Secondary accession number(s): Q93S46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 11, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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