Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q1DB00

- MASK_MYXXD

UniProt

Q1DB00 - MASK_MYXXD

Protein

Tyrosine-protein kinase MasK

Gene

masK

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Essential for growth. Interacts with MglA to control social gliding motility.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei57 – 571ATPPROSITE-ProRule annotation
    Active sitei163 – 1631Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMXAN246197:GIWU-1911-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase MasK (EC:2.7.10.2)
    Gene namesi
    Name:masK
    Ordered Locus Names:MXAN_1929
    OrganismiMyxococcus xanthus (strain DK 1622)
    Taxonomic identifieri246197 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
    ProteomesiUP000002402: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 646646Tyrosine-protein kinase MasKPRO_0000282835Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Interactioni

    Subunit structurei

    Interacts with MglA.1 Publication

    Protein-protein interaction databases

    STRINGi246197.MXAN_1929.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1DB00.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 415415PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini434 – 646213CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei416 – 43318HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 300276Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi456 – 53984Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK08884.
    OMAiICMEYLA.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1DB00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPPQTTLPV TEAGLVPLLQ PYGPYVLVRK LAEGGMAEIF LAKLLGADGF    50
    ERNVVIKRML PHLTNNPDFV EMFRDEARLA AKLAHPNIVQ IQELGFAEGC 100
    YYICMEYLAG EDFSTTLRLA GRKRHYVPLP VVLRVLIDAA RGLHFAHEFT 150
    NEAGQPLNVV HRDISPSNLY LTYQGQVKVL DFGIAKAESR LVNTRTGVVK 200
    GKYMYMAPEQ ARGKEVDRRA DIFALGVSLY EALTHVRPFS RENDLAVLNA 250
    LLQGELKPPR ELRPDLPEEL EAILLKAMAF KPEDRYPTAE AFADALETFL 300
    SEHLSGSGAM PLGAFLKGHF GEERFTERSR IPTLATLTAT YGGAAAGAQG 350
    QAPGAEPHGT NLYGVLAREG DATSAQRPGM SMRPSSPGVP AHGAASRGST 400
    SPESAPTAGG RRWRTLAVGL AGGLMLAAAG IVGYRQWMTT PASVSLVPAT 450
    VPVVEAVAPE AAAAQVGAPM EAVAPVGAAA QAGSLTDAVA NGAGGDVGET 500
    DSAQLSVDAA GVTETDEAGL AGAASDVEAE ADEEGADAAP VRSKKASSQK 550
    RVTLGIDDVQ RVVSRGRARI TTCFERYKAD LPSSQGEVQV QLTIVSSGKV 600
    RAGTRGPLAS SGVGRCLEAQ AERLRFPPHR DQEVTVVMPF SWRVTQ 646
    Length:646
    Mass (Da):68,576
    Last modified:July 11, 2006 - v1
    Checksum:iC9667634284FE40C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF377950 Genomic DNA. Translation: AAK54653.1.
    CP000113 Genomic DNA. Translation: ABF90801.1.
    RefSeqiWP_011552028.1. NC_008095.1.
    YP_630173.1. NC_008095.1.

    Genome annotation databases

    EnsemblBacteriaiABF90801; ABF90801; MXAN_1929.
    GeneIDi4105479.
    KEGGimxa:MXAN_1929.
    PATRICi22646407. VBIMyxXan43560_1900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF377950 Genomic DNA. Translation: AAK54653.1 .
    CP000113 Genomic DNA. Translation: ABF90801.1 .
    RefSeqi WP_011552028.1. NC_008095.1.
    YP_630173.1. NC_008095.1.

    3D structure databases

    ProteinModelPortali Q1DB00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246197.MXAN_1929.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF90801 ; ABF90801 ; MXAN_1929 .
    GeneIDi 4105479.
    KEGGi mxa:MXAN_1929.
    PATRICi 22646407. VBIMyxXan43560_1900.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K08884.
    OMAi ICMEYLA.
    OrthoDBi EOG6B35XT.

    Enzyme and pathway databases

    BioCyci MXAN246197:GIWU-1911-MONOMER.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gliding motility in Myxococcus xanthus: mgl locus, RNA, and predicted protein products."
      Stephens K., Hartzell P.L., Kaiser D.
      J. Bacteriol. 171:819-830(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DK 1622.
    3. "MglA, a small GTPase, interacts with a tyrosine kinase to control type IV pili-mediated motility and development of Myxococcus xanthus."
      Thomasson B., Link J., Stassinopoulos A.G., Burke N., Plamann L., Hartzell P.L.
      Mol. Microbiol. 46:1399-1413(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, INTERACTION WITH MGLA.

    Entry informationi

    Entry nameiMASK_MYXXD
    AccessioniPrimary (citable) accession number: Q1DB00
    Secondary accession number(s): Q93S46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3