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Q1DB00 (MASK_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase MasK

EC=2.7.10.2
Gene names
Name:masK
Ordered Locus Names:MXAN_1929
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length646 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for growth. Interacts with MglA to control social gliding motility.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with MglA. Ref.3

Subcellular location

Cell inner membrane; Single-pass membrane protein Potential.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 646646Tyrosine-protein kinase MasK
PRO_0000282835

Regions

Topological domain1 – 415415Periplasmic Potential
Transmembrane416 – 43318Helical; Potential
Topological domain434 – 646213Cytoplasmic Potential
Domain25 – 300276Protein kinase
Nucleotide binding31 – 399ATP By similarity
Compositional bias456 – 53984Ala-rich

Sites

Active site1631Proton acceptor By similarity
Binding site571ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1DB00 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: C9667634284FE40C

FASTA64668,576
        10         20         30         40         50         60 
MSPPQTTLPV TEAGLVPLLQ PYGPYVLVRK LAEGGMAEIF LAKLLGADGF ERNVVIKRML 

        70         80         90        100        110        120 
PHLTNNPDFV EMFRDEARLA AKLAHPNIVQ IQELGFAEGC YYICMEYLAG EDFSTTLRLA 

       130        140        150        160        170        180 
GRKRHYVPLP VVLRVLIDAA RGLHFAHEFT NEAGQPLNVV HRDISPSNLY LTYQGQVKVL 

       190        200        210        220        230        240 
DFGIAKAESR LVNTRTGVVK GKYMYMAPEQ ARGKEVDRRA DIFALGVSLY EALTHVRPFS 

       250        260        270        280        290        300 
RENDLAVLNA LLQGELKPPR ELRPDLPEEL EAILLKAMAF KPEDRYPTAE AFADALETFL 

       310        320        330        340        350        360 
SEHLSGSGAM PLGAFLKGHF GEERFTERSR IPTLATLTAT YGGAAAGAQG QAPGAEPHGT 

       370        380        390        400        410        420 
NLYGVLAREG DATSAQRPGM SMRPSSPGVP AHGAASRGST SPESAPTAGG RRWRTLAVGL 

       430        440        450        460        470        480 
AGGLMLAAAG IVGYRQWMTT PASVSLVPAT VPVVEAVAPE AAAAQVGAPM EAVAPVGAAA 

       490        500        510        520        530        540 
QAGSLTDAVA NGAGGDVGET DSAQLSVDAA GVTETDEAGL AGAASDVEAE ADEEGADAAP 

       550        560        570        580        590        600 
VRSKKASSQK RVTLGIDDVQ RVVSRGRARI TTCFERYKAD LPSSQGEVQV QLTIVSSGKV 

       610        620        630        640 
RAGTRGPLAS SGVGRCLEAQ AERLRFPPHR DQEVTVVMPF SWRVTQ 

« Hide

References

« Hide 'large scale' references
[1]"Gliding motility in Myxococcus xanthus: mgl locus, RNA, and predicted protein products."
Stephens K., Hartzell P.L., Kaiser D.
J. Bacteriol. 171:819-830(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evolution of sensory complexity recorded in a myxobacterial genome."
Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. expand/collapse author list , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.
Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DK 1622.
[3]"MglA, a small GTPase, interacts with a tyrosine kinase to control type IV pili-mediated motility and development of Myxococcus xanthus."
Thomasson B., Link J., Stassinopoulos A.G., Burke N., Plamann L., Hartzell P.L.
Mol. Microbiol. 46:1399-1413(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, INTERACTION WITH MGLA.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF377950 Genomic DNA. Translation: AAK54653.1.
CP000113 Genomic DNA. Translation: ABF90801.1.
RefSeqYP_630173.1. NC_008095.1.

3D structure databases

ProteinModelPortalQ1DB00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246197.MXAN_1929.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF90801; ABF90801; MXAN_1929.
GeneID4105479.
KEGGmxa:MXAN_1929.
PATRIC22646407. VBIMyxXan43560_1900.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0515.
KOK08884.
OMAICMEYLA.
OrthoDBEOG6B35XT.
ProtClustDBCLSK2778165.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-1911-MONOMER.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMASK_MYXXD
AccessionPrimary (citable) accession number: Q1DB00
Secondary accession number(s): Q93S46
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families