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Q1DAN8

- PANC_MYXXD

UniProt

Q1DAN8 - PANC_MYXXD

Protein

Pantothenate synthetase

Gene

panC

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391Proton donorUniRule annotation
    Binding sitei63 – 631Beta-alanineUniRule annotation
    Binding sitei63 – 631PantoateUniRule annotation
    Binding sitei156 – 1561PantoateUniRule annotation
    Binding sitei179 – 1791ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi32 – 398ATPUniRule annotation
    Nucleotide bindingi150 – 1534ATPUniRule annotation
    Nucleotide bindingi187 – 1904ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMXAN246197:GIWU-2035-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:MXAN_2056
    OrganismiMyxococcus xanthus (strain DK 1622)
    Taxonomic identifieri246197 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
    ProteomesiUP000002402: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Pantothenate synthetasePRO_0000305494Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi246197.MXAN_2056.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1DAN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiIHTIREL.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1DAN8-1 [UniParc]FASTAAdd to Basket

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    MAPAVLKTVA DVKDWTAGLR REGHRLALVP TMGFLHEGHL SLIREGRRRA    50
    DVVAVSIFVN PTQFGPKEDL SRYPRDFEGD VAKCISAGAQ AIFAPAGPEV 100
    MYPQGYQTYV EVTDVSQGLC GARRPGHFRG VATVVTKLLT LFRPEVALFG 150
    EKDYQQLQVI RALNQDLHLG ADIVGMPTVR EPDGLAMSSR NAYLSPEERQ 200
    RALALSRGLK AAQALLREGT RESEPLVAAV RRELEAAGLR EDYVELVDAE 250
    RLTPLASVAP GQPARLLVAA FSGTTRLIDN MQLGGEENAG RV 292
    Length:292
    Mass (Da):31,778
    Last modified:July 11, 2006 - v1
    Checksum:i66D607FAC689ECEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000113 Genomic DNA. Translation: ABF90225.1.
    RefSeqiYP_630285.1. NC_008095.1.

    Genome annotation databases

    EnsemblBacteriaiABF90225; ABF90225; MXAN_2056.
    GeneIDi4102344.
    KEGGimxa:MXAN_2056.
    PATRICi22646667. VBIMyxXan43560_2020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000113 Genomic DNA. Translation: ABF90225.1 .
    RefSeqi YP_630285.1. NC_008095.1.

    3D structure databases

    ProteinModelPortali Q1DAN8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246197.MXAN_2056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF90225 ; ABF90225 ; MXAN_2056 .
    GeneIDi 4102344.
    KEGGi mxa:MXAN_2056.
    PATRICi 22646667. VBIMyxXan43560_2020.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi IHTIREL.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci MXAN246197:GIWU-2035-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DK 1622.

    Entry informationi

    Entry nameiPANC_MYXXD
    AccessioniPrimary (citable) accession number: Q1DAN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3