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Q1D8V5

- PUR5_MYXXD

UniProt

Q1D8V5 - PUR5_MYXXD

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, MXAN_2701
Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMXAN246197:GIWU-2678-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:MXAN_2701
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
ProteomesiUP000002402: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000258372Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_2701.

Structurei

3D structure databases

ProteinModelPortaliQ1D8V5.
SMRiQ1D8V5. Positions 3-344.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1D8V5-1 [UniParc]FASTAAdd to Basket

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MGTTYKQSGV DIEAGDAFVE RIKPHAARTM RPEVMGGVGG FGGLFALPPG    50
KYQQPVLVAG TDGVGTKLKV AFAAGRHGTV GIDLVAMSVN DILTCGAEPL 100
FFLDYFATGR LEVDDAAEVV KGIALGCEQA GCALLGGETA EMPGFYARGE 150
YDLAGFCVGV VERAAIIDGK SVKPGDALIG LPSSGLHSNG YSLARKVLLD 200
DGKLALDATP EGLDRPLVDA LLEPTRIYVK DVLALLQAVK VKGLAHITGS 250
GIPGNLPRCL PDGTRAVLSE QTWPKPPIFD LIAKLGSVAR DEMFNTFNMG 300
LGLILVVAKE DVAQALSVLS GRGVQAFEVG RVEAGQGEAT AVIDP 345
Length:345
Mass (Da):35,858
Last modified:July 11, 2006 - v1
Checksum:i0B94449A50C37F14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000113 Genomic DNA. Translation: ABF92152.1.
RefSeqiYP_630918.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF92152; ABF92152; MXAN_2701.
GeneIDi4106841.
KEGGimxa:MXAN_2701.
PATRICi22647937. VBIMyxXan43560_2653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000113 Genomic DNA. Translation: ABF92152.1 .
RefSeqi YP_630918.1. NC_008095.1.

3D structure databases

ProteinModelPortali Q1D8V5.
SMRi Q1D8V5. Positions 3-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246197.MXAN_2701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF92152 ; ABF92152 ; MXAN_2701 .
GeneIDi 4106841.
KEGGi mxa:MXAN_2701.
PATRICi 22647937. VBIMyxXan43560_2653.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci MXAN246197:GIWU-2678-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DK 1622.

Entry informationi

Entry nameiPUR5_MYXXD
AccessioniPrimary (citable) accession number: Q1D8V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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