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Q1D8L9 (HGD_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:MXAN_2787
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
   Biological processPhenylalanine catabolism
Tyrosine catabolism
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-phenylalanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionhomogentisate 1,2-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_1000119844

Sites

Metal binding3381Iron By similarity
Metal binding3441Iron By similarity
Metal binding3741Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1D8L9 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 81D91E3D65FD8B54

FASTA43747,825
        10         20         30         40         50         60 
MSPGSVLKTA PGAYLSGFGN EFATEAVPGA LPEGQNSPQR APFGLYAEQL SGSAFTAPRR 

        70         80         90        100        110        120 
ENRRSWLYRL RPSANHPAFQ PLAQGLLRSG PFDEVPASPN RLRWSPQPPP AQPTDFVDGL 

       130        140        150        160        170        180 
VTYAGNGDAA SGAGISIHLY AANRSMVDRV FFDADGELLI VPQAGRLRLV TELGVLDVAP 

       190        200        210        220        230        240 
GEIAVVPRGV RFRAELPEGQ AAGYVCENHG AFFRLPDLGP IGANGLANPR DFLTPVAAFE 

       250        260        270        280        290        300 
DVDRPTEVVQ KFLGRLWSAR YSYSPLDVVA WHGNLVPYKY DLARFNTINT VSFDHPDPSI 

       310        320        330        340        350        360 
FTVLTSPSEV PGTANCDFVI FPPRWMVAEH TFRPPWFHRN VMSEFMGLVH GVYDAKAGGF 

       370        380        390        400        410        420 
APGGGSLHNC MSGHGPDRTS YEQAIQADLK PHKIKDTLAF MFESRWVIRP TRFAMETPAL 

       430 
QQDYDACWAG FQKAKLP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000113 Genomic DNA. Translation: ABF89328.1.
RefSeqYP_631004.1. NC_008095.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246197.MXAN_2787.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF89328; ABF89328; MXAN_2787.
GeneID4103449.
KEGGmxa:MXAN_2787.
PATRIC22648115. VBIMyxXan43560_2742.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-2764-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_MYXXD
AccessionPrimary (citable) accession number: Q1D8L9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 11, 2006
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways