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Q1D8L9

- HGD_MYXXD

UniProt

Q1D8L9 - HGD_MYXXD

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei295 – 2951Proton acceptorUniRule annotation
Metal bindingi338 – 3381IronUniRule annotation
Metal bindingi344 – 3441IronUniRule annotation
Binding sitei353 – 3531homogentisateUniRule annotation
Metal bindingi374 – 3741IronUniRule annotation
Binding sitei374 – 3741homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMXAN246197:GIWU-2764-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:MXAN_2787
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
ProteomesiUP000002402: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Homogentisate 1,2-dioxygenasePRO_1000119844Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi246197.MXAN_2787.

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1D8L9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPGSVLKTA PGAYLSGFGN EFATEAVPGA LPEGQNSPQR APFGLYAEQL
60 70 80 90 100
SGSAFTAPRR ENRRSWLYRL RPSANHPAFQ PLAQGLLRSG PFDEVPASPN
110 120 130 140 150
RLRWSPQPPP AQPTDFVDGL VTYAGNGDAA SGAGISIHLY AANRSMVDRV
160 170 180 190 200
FFDADGELLI VPQAGRLRLV TELGVLDVAP GEIAVVPRGV RFRAELPEGQ
210 220 230 240 250
AAGYVCENHG AFFRLPDLGP IGANGLANPR DFLTPVAAFE DVDRPTEVVQ
260 270 280 290 300
KFLGRLWSAR YSYSPLDVVA WHGNLVPYKY DLARFNTINT VSFDHPDPSI
310 320 330 340 350
FTVLTSPSEV PGTANCDFVI FPPRWMVAEH TFRPPWFHRN VMSEFMGLVH
360 370 380 390 400
GVYDAKAGGF APGGGSLHNC MSGHGPDRTS YEQAIQADLK PHKIKDTLAF
410 420 430
MFESRWVIRP TRFAMETPAL QQDYDACWAG FQKAKLP
Length:437
Mass (Da):47,825
Last modified:July 11, 2006 - v1
Checksum:i81D91E3D65FD8B54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA. Translation: ABF89328.1.
RefSeqiYP_631004.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF89328; ABF89328; MXAN_2787.
GeneIDi4103449.
KEGGimxa:MXAN_2787.
PATRICi22648115. VBIMyxXan43560_2742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA. Translation: ABF89328.1 .
RefSeqi YP_631004.1. NC_008095.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246197.MXAN_2787.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF89328 ; ABF89328 ; MXAN_2787 .
GeneIDi 4103449.
KEGGi mxa:MXAN_2787.
PATRICi 22648115. VBIMyxXan43560_2742.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci MXAN246197:GIWU-2764-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DK 1622.

Entry informationi

Entry nameiHGD_MYXXD
AccessioniPrimary (citable) accession number: Q1D8L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 11, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3