Q1D8L9 (HGD_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homogentisate 1,2-dioxygenase
EC=1.13.11.5

Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase

Gene names

Name:	hmgA
Ordered Locus Names:	MXAN_2787

Organism

Myxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]

Taxonomic identifier

246197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity. HAMAP MF_00334
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_1000119844
Sites
	Metal binding	338	1	Iron By similarity
	Metal binding	344	1	Iron By similarity
	Metal binding	374	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1D8L9 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 81D91E3D65FD8B54	FASTA	437	47,825
	10 20 30 40 50 60 MSPGSVLKTA PGAYLSGFGN EFATEAVPGA LPEGQNSPQR APFGLYAEQL SGSAFTAPRR 70 80 90 100 110 120 ENRRSWLYRL RPSANHPAFQ PLAQGLLRSG PFDEVPASPN RLRWSPQPPP AQPTDFVDGL 130 140 150 160 170 180 VTYAGNGDAA SGAGISIHLY AANRSMVDRV FFDADGELLI VPQAGRLRLV TELGVLDVAP 190 200 210 220 230 240 GEIAVVPRGV RFRAELPEGQ AAGYVCENHG AFFRLPDLGP IGANGLANPR DFLTPVAAFE 250 260 270 280 290 300 DVDRPTEVVQ KFLGRLWSAR YSYSPLDVVA WHGNLVPYKY DLARFNTINT VSFDHPDPSI 310 320 330 340 350 360 FTVLTSPSEV PGTANCDFVI FPPRWMVAEH TFRPPWFHRN VMSEFMGLVH GVYDAKAGGF 370 380 390 400 410 420 APGGGSLHNC MSGHGPDRTS YEQAIQADLK PHKIKDTLAF MFESRWVIRP TRFAMETPAL 430 QQDYDACWAG FQKAKLP

References

[1]

"Evolution of sensory complexity recorded in a myxobacterial genome." Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B. Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed: 17015832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DK 1622.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000113 Genomic DNA. Translation: ABF89328.1.
RefSeq	YP_631004.1. NC_008095.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1D8L9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4103449.
GenomeReviews	Gene locus MXAN_2787 in contig CP000113_GR.
KEGG	mxa:MXAN_2787.
PATRIC	22648115. VBIMyxXan43560_2742.
TIGR	MXAN_2787.
Phylogenomic databases
eggNOG	COG3508.
HOGENOM	HBG293508.
OMA	RNCMSEF.
ProtClustDB	PRK05341.
Enzyme and pathway databases
BioCyc	MXAN246197:MXAN_2787-MONOMER.
Family and domain databases
HAMAP	MF_00334. Homogentis_dioxygen. [Tree]
InterPro	IPR011051. Cupin_RmlC_type. IPR005708. Homogentis_dOase. IPR022950. Homogentis_dOase_bac. [Graphical view]
KO	K00451.
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR01015. HmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_MYXXD

Accession

Primary (citable) accession number: Q1D8L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program