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Q1D898 (PUR9_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:MXAN_2914
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018916

Sequences

Sequence LengthMass (Da)Tools
Q1D898 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: CE89D55F723A1984

FASTA51454,953
        10         20         30         40         50         60 
MLALLSVSDK RGLVPFAQGL VRLGFRLLST GGTLEALKGA GVPVNKVSEH TQSPEILGGR 

        70         80         90        100        110        120 
VKTLHPRIHG GILGRLELEA DREEMKAHGI EPISLVAVNL YPFRQTVASG AAEPEVIEQI 

       130        140        150        160        170        180 
DIGGPAMVRA SAKNFRHVSV VVDPDDYPAV LAELEQQKAV SEDTRRRLMR KAFAHTAAYD 

       190        200        210        220        230        240 
ASISAWLSAQ AGEPFPGELS LAFQKSQDLR YGENPHQRGA FYREHAAPQE PTVAFAKVLQ 

       250        260        270        280        290        300 
GKELSYNNIL DLDAALGLLL EFPEAPAAVI IKHNTPCGVA VDAALVKAYR TARAVDEVSA 

       310        320        330        340        350        360 
FGGIVALNRE VDAATAQAMA ETFLEAVIAP SYSPEALQVL ATKKNLRLLE AGPALASPQA 

       370        380        390        400        410        420 
RPRAQLDARS VSGGMLLMDR DSVEPPLSWK VVSKRAPTPE EEQAMRFAWK VCKHVKSNAI 

       430        440        450        460        470        480 
VFASGDQLLA QGGGQTNRVD SVRIAMQRGG AALRGSAVAS DAFFPFRDGL DEAARAGATC 

       490        500        510 
VVQPGGSVRD AELIAAADEH GMAMVLTGVR HFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000113 Genomic DNA. Translation: ABF88926.1.
RefSeqYP_631125.1. NC_008095.1.

3D structure databases

ProteinModelPortalQ1D898.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246197.MXAN_2914.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF88926; ABF88926; MXAN_2914.
GeneID4101505.
KEGGmxa:MXAN_2914.
PATRIC22648377. VBIMyxXan43560_2868.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-2890-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_MYXXD
AccessionPrimary (citable) accession number: Q1D898
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways