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Q1D823

- AGLZ_MYXXD

UniProt

Q1D823 - AGLZ_MYXXD

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Protein
Adventurous-gliding motility protein Z
Gene
aglZ, MXAN_2991
Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for adventurous-gliding motility (A motility), in response to environmental signals sensed by the frz chemosensory system. Forms ordered clusters that span the cell length and that remain stationary relative to the surface across which the cells move, serving as anchor points (focal, transient adhesion sites) that allow the bacterium to move forward. Clusters disassemble at the lagging cell pole.2 Publications

GO - Molecular functioni

  1. phosphorelay response regulator activity Source: InterPro
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Motor protein

    Enzyme and pathway databases

    BioCyciMXAN246197:GIWU-2964-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adventurous-gliding motility protein Z
    Gene namesi
    Name:aglZ
    Ordered Locus Names:MXAN_2991
    OrganismiMyxococcus xanthus (strain DK 1622)
    Taxonomic identifieri246197 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
    ProteomesiUP000002402: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: In motile cells, localizes in ordered clusters spanning the cell length. In stalled cells, localizes at the leading cell pole.1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13951395Adventurous-gliding motility protein Z
    PRO_0000282834Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei48 – 4814-aspartylphosphate Reviewed prediction

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with MglA.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    frzCDQ1D4V74EBI-1574592,EBI-6407529

    Protein-protein interaction databases

    IntActiQ1D823. 13 interactions.
    MINTiMINT-7718200.
    STRINGi246197.MXAN_2991.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1D823.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 122119Response regulatory
    Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili213 – 911699 Reviewed prediction
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi123 – 21290Pro-rich
    Add
    BLAST
    Compositional biasi1095 – 1361267Ala-rich
    Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG12793.
    OMAiREEQNKF.
    OrthoDBiEOG6PS5T9.

    Family and domain databases

    InterProiIPR011006. CheY-like_superfamily.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1D823-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERRVLIVES EHDFALSMAT VLKGAGYQTA LAETAADAQR ELEKRRPDLV     50
    VLRAELKDQS GFVLCGNIKK GKWGQNLKVL LLSSESGVDG LAQHRQTPQA 100
    ADGYLAIPFE MGELAALSHG IVPPGTDDTG ASLDAALNGT REAPPPMPPS 150
    LKAAAGGPPK LPKRERRSAM TEEDRAFLDR TFQSIADRKA ELLAESRQLK 200
    RPPPRRELMG TPEGKIQILR DELKTREAQL ARLSEIWNVR ERELLSGEDR 250
    IHEKDVELQG LKMQVDDLLR RFNEAQQATI QKEREHGATV DDLLLQKFSA 300
    EKDLIEVVAS KEKDINLLRR EVSRAEEELS RRAGELEHGR NEYDKLEKHL 350
    GVVTLEFEVK EQKLQDTVLA NEGEIARLTK RGDDFEAELN RTISERDQRF 400
    AELDGEIQAL QERLQQTEQE RDTTVRGLEA RAARAEEHGT QADAEIHRLN 450
    AERDALEAKL SQQVADLEAD LARTMGERDQ LRLDKDAQEA ELTQRIEERD 500
    AKLGTLEREL SETIARNEHT EAELNANIQQ QLERIGELEG EVEAVKTHLE 550
    DRENELTAEL QALGQAKDEL ETDLNDRLQA LSQAKDALEA DLSRQLEELR 600
    SAKAELEADL TGQIQALTSQ LEETQRQLDD SQRTGEQLSA RVAQLEDTVS 650
    QRESTIESLQ GDVAARDQRI SELSGDLEAT SQTLAQTQQT LAQTEQQLAD 700
    TQNTLASTEG ALAETRGELD ATSQTLQQTQ QTLAQTEGAL AETRGELDAT 750
    SQTLAQTQQT LAQTEQQLAD TQNTLASTEG TLAETRGELE ATSQTLQQTH 800
    AALEDTRGAL QETSDTLAHT TRERDQRIAE LADLGAAKDA LEQELTGQIG 850
    HLRSELSETQ GNYEAERAAH EKLAAESSAH IGDLTSERDG LRSELEATSQ 900
    TLEQTHGQLA ATRDALAREQ HAHQESRKAA ASTQTTLEGQ LAEARAHGED 950
    LGEHLTLTKH ELGTRVAELT QLTATLAQTE NTRAHLEERL HTLTEESQRR 1000
    EELLQNDLTQ KGTELSDTLR KLTHVTQEKM RQAEVLNREV ATRTEQLKAM 1050
    EAKLQTQATE ARRQAEGLGQ QITGLNEQLE QGRKALAGRE DQLRAAGAAQ 1100
    QKLTAERDGL AGQLQQAEAR LQQQAQQANQ ERADAKRAAD ELAAKLAKTE 1150
    QRITQFAQDA QTQATEADAR AKDLQGQLSA RAKKIQDLEL AVENAQGAKS 1200
    RAEKELNAKV AAAESKAHEA STRLAAAQKE RKDLEARHAK EQEDLAAKQK 1250
    AELERRDAIK AQEVARLQQS VQEKSKALKV AELELARYKS KSATTATPAK 1300
    AAAKPAAAED DELAVRTQLN QVIAPAAAAQ APAPAKKPAA KPAAQAPAKK 1350
    APAPAPAPPA ALSDESEPTD RTLVIQLPTA KEDDDWTALV DELDK 1395
    Length:1,395
    Mass (Da):153,616
    Last modified:July 11, 2006 - v1
    Checksum:i5E20D7DC3181E36A
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti763 – 7631Q → R in AAR39422. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY487937 Genomic DNA. Translation: AAR39422.1.
    CP000113 Genomic DNA. Translation: ABF92300.1.
    RefSeqiYP_631200.1. NC_008095.1.

    Genome annotation databases

    EnsemblBacteriaiABF92300; ABF92300; MXAN_2991.
    GeneIDi4106990.
    KEGGimxa:MXAN_2991.
    PATRICi22648533. VBIMyxXan43560_2946.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Slip sliding away - Issue 81 of April 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY487937 Genomic DNA. Translation: AAR39422.1 .
    CP000113 Genomic DNA. Translation: ABF92300.1 .
    RefSeqi YP_631200.1. NC_008095.1.

    3D structure databases

    ProteinModelPortali Q1D823.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi Q1D823. 13 interactions.
    MINTi MINT-7718200.
    STRINGi 246197.MXAN_2991.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF92300 ; ABF92300 ; MXAN_2991 .
    GeneIDi 4106990.
    KEGGi mxa:MXAN_2991.
    PATRICi 22648533. VBIMyxXan43560_2946.

    Phylogenomic databases

    eggNOGi NOG12793.
    OMAi REEQNKF.
    OrthoDBi EOG6PS5T9.

    Enzyme and pathway databases

    BioCyci MXAN246197:GIWU-2964-MONOMER.

    Family and domain databases

    InterProi IPR011006. CheY-like_superfamily.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "AglZ is a filament-forming coiled-coil protein required for adventurous gliding motility of Myxococcus xanthus."
      Yang R., Bartle S., Otto R., Stassinopoulos A.G., Rogers M., Plamann L., Hartzell P.L.
      J. Bacteriol. 186:6168-6178(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH MGLA.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DK 1622.
    3. "Evidence that focal adhesion complexes power bacterial gliding motility."
      Mignot T., Shaevitz J.W., Hartzell P.L., Zusman D.R.
      Science 315:853-856(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ROLE IN A-TYPE GLIDING MOTILITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAGLZ_MYXXD
    AccessioniPrimary (citable) accession number: Q1D823
    Secondary accession number(s): Q6RW49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: July 11, 2006
    Last modified: June 11, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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