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Q1D823 (AGLZ_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adventurous-gliding motility protein Z
Gene names
Name:aglZ
Ordered Locus Names:MXAN_2991
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length1395 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for adventurous-gliding motility (A motility), in response to environmental signals sensed by the frz chemosensory system. Forms ordered clusters that span the cell length and that remain stationary relative to the surface across which the cells move, serving as anchor points (focal, transient adhesion sites) that allow the bacterium to move forward. Clusters disassemble at the lagging cell pole. Ref.1 Ref.3

Subunit structure

Interacts with MglA. Ref.1

Subcellular location

Cytoplasm. Note: In motile cells, localizes in ordered clusters spanning the cell length. In stalled cells, localizes at the leading cell pole. Ref.3

Sequence similarities

Contains 1 response regulatory domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainCoiled coil
   Molecular functionMotor protein
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphorelay response regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

frzCDQ1D4V74EBI-1574592,EBI-6407529

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13951395Adventurous-gliding motility protein Z
PRO_0000282834

Regions

Domain4 – 122119Response regulatory
Coiled coil213 – 911699 Potential
Compositional bias123 – 21290Pro-rich
Compositional bias1095 – 1361267Ala-rich

Amino acid modifications

Modified residue4814-aspartylphosphate Potential

Experimental info

Sequence conflict7631Q → R in AAR39422. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q1D823 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 5E20D7DC3181E36A

FASTA1,395153,616
        10         20         30         40         50         60 
MERRVLIVES EHDFALSMAT VLKGAGYQTA LAETAADAQR ELEKRRPDLV VLRAELKDQS 

        70         80         90        100        110        120 
GFVLCGNIKK GKWGQNLKVL LLSSESGVDG LAQHRQTPQA ADGYLAIPFE MGELAALSHG 

       130        140        150        160        170        180 
IVPPGTDDTG ASLDAALNGT REAPPPMPPS LKAAAGGPPK LPKRERRSAM TEEDRAFLDR 

       190        200        210        220        230        240 
TFQSIADRKA ELLAESRQLK RPPPRRELMG TPEGKIQILR DELKTREAQL ARLSEIWNVR 

       250        260        270        280        290        300 
ERELLSGEDR IHEKDVELQG LKMQVDDLLR RFNEAQQATI QKEREHGATV DDLLLQKFSA 

       310        320        330        340        350        360 
EKDLIEVVAS KEKDINLLRR EVSRAEEELS RRAGELEHGR NEYDKLEKHL GVVTLEFEVK 

       370        380        390        400        410        420 
EQKLQDTVLA NEGEIARLTK RGDDFEAELN RTISERDQRF AELDGEIQAL QERLQQTEQE 

       430        440        450        460        470        480 
RDTTVRGLEA RAARAEEHGT QADAEIHRLN AERDALEAKL SQQVADLEAD LARTMGERDQ 

       490        500        510        520        530        540 
LRLDKDAQEA ELTQRIEERD AKLGTLEREL SETIARNEHT EAELNANIQQ QLERIGELEG 

       550        560        570        580        590        600 
EVEAVKTHLE DRENELTAEL QALGQAKDEL ETDLNDRLQA LSQAKDALEA DLSRQLEELR 

       610        620        630        640        650        660 
SAKAELEADL TGQIQALTSQ LEETQRQLDD SQRTGEQLSA RVAQLEDTVS QRESTIESLQ 

       670        680        690        700        710        720 
GDVAARDQRI SELSGDLEAT SQTLAQTQQT LAQTEQQLAD TQNTLASTEG ALAETRGELD 

       730        740        750        760        770        780 
ATSQTLQQTQ QTLAQTEGAL AETRGELDAT SQTLAQTQQT LAQTEQQLAD TQNTLASTEG 

       790        800        810        820        830        840 
TLAETRGELE ATSQTLQQTH AALEDTRGAL QETSDTLAHT TRERDQRIAE LADLGAAKDA 

       850        860        870        880        890        900 
LEQELTGQIG HLRSELSETQ GNYEAERAAH EKLAAESSAH IGDLTSERDG LRSELEATSQ 

       910        920        930        940        950        960 
TLEQTHGQLA ATRDALAREQ HAHQESRKAA ASTQTTLEGQ LAEARAHGED LGEHLTLTKH 

       970        980        990       1000       1010       1020 
ELGTRVAELT QLTATLAQTE NTRAHLEERL HTLTEESQRR EELLQNDLTQ KGTELSDTLR 

      1030       1040       1050       1060       1070       1080 
KLTHVTQEKM RQAEVLNREV ATRTEQLKAM EAKLQTQATE ARRQAEGLGQ QITGLNEQLE 

      1090       1100       1110       1120       1130       1140 
QGRKALAGRE DQLRAAGAAQ QKLTAERDGL AGQLQQAEAR LQQQAQQANQ ERADAKRAAD 

      1150       1160       1170       1180       1190       1200 
ELAAKLAKTE QRITQFAQDA QTQATEADAR AKDLQGQLSA RAKKIQDLEL AVENAQGAKS 

      1210       1220       1230       1240       1250       1260 
RAEKELNAKV AAAESKAHEA STRLAAAQKE RKDLEARHAK EQEDLAAKQK AELERRDAIK 

      1270       1280       1290       1300       1310       1320 
AQEVARLQQS VQEKSKALKV AELELARYKS KSATTATPAK AAAKPAAAED DELAVRTQLN 

      1330       1340       1350       1360       1370       1380 
QVIAPAAAAQ APAPAKKPAA KPAAQAPAKK APAPAPAPPA ALSDESEPTD RTLVIQLPTA 

      1390 
KEDDDWTALV DELDK 

« Hide

References

« Hide 'large scale' references
[1]"AglZ is a filament-forming coiled-coil protein required for adventurous gliding motility of Myxococcus xanthus."
Yang R., Bartle S., Otto R., Stassinopoulos A.G., Rogers M., Plamann L., Hartzell P.L.
J. Bacteriol. 186:6168-6178(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH MGLA.
[2]"Evolution of sensory complexity recorded in a myxobacterial genome."
Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. expand/collapse author list , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.
Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DK 1622.
[3]"Evidence that focal adhesion complexes power bacterial gliding motility."
Mignot T., Shaevitz J.W., Hartzell P.L., Zusman D.R.
Science 315:853-856(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ROLE IN A-TYPE GLIDING MOTILITY, SUBCELLULAR LOCATION.

Web resources

Protein Spotlight

Slip sliding away - Issue 81 of April 2007

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY487937 Genomic DNA. Translation: AAR39422.1.
CP000113 Genomic DNA. Translation: ABF92300.1.
RefSeqYP_631200.1. NC_008095.1.

3D structure databases

ProteinModelPortalQ1D823.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ1D823. 13 interactions.
MINTMINT-7718200.
STRING246197.MXAN_2991.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF92300; ABF92300; MXAN_2991.
GeneID4106990.
KEGGmxa:MXAN_2991.
PATRIC22648533. VBIMyxXan43560_2946.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG12793.
OMAREEQNKF.
OrthoDBEOG6PS5T9.
ProtClustDBCLSK946360.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-2964-MONOMER.

Family and domain databases

InterProIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAGLZ_MYXXD
AccessionPrimary (citable) accession number: Q1D823
Secondary accession number(s): Q6RW49
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries