Q1D823 (AGLZ_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adventurous-gliding motility protein Z

Gene names

Name:	aglZ
Ordered Locus Names:	MXAN_2991

Organism

Myxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]

Taxonomic identifier

246197 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus › Myxococcus xanthus

Protein attributes

Sequence length	1395 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for adventurous-gliding motility (A motility), in response to environmental signals sensed by the frz chemosensory system. Forms ordered clusters that span the cell length and that remain stationary relative to the surface across which the cells move, serving as anchor points (focal, transient adhesion sites) that allow the bacterium to move forward. Clusters disassemble at the lagging cell pole. Ref.1 Ref.3
Subunit structure	Interacts with MglA. Ref.1
Subcellular location	Cytoplasm. Note: In motile cells, localizes in ordered clusters spanning the cell length. In stalled cells, localizes at the leading cell pole. Ref.3
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
frzCD	Q1D4V7	4	EBI-1574592,EBI-6407529

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1395	1395	Adventurous-gliding motility protein Z		PRO_0000282834
Regions
	Domain	4 – 122	119	Response regulatory
	Coiled coil	213 – 911	699	Potential
	Compositional bias	123 – 212	90	Pro-rich
	Compositional bias	1095 – 1361	267	Ala-rich
Amino acid modifications
	Modified residue	48	1	4-aspartylphosphate Potential
Experimental info
	Sequence conflict	763	1	Q → R in AAR39422. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q1D823 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 5E20D7DC3181E36A	FASTA	1,395	153,616
	10 20 30 40 50 60 MERRVLIVES EHDFALSMAT VLKGAGYQTA LAETAADAQR ELEKRRPDLV VLRAELKDQS 70 80 90 100 110 120 GFVLCGNIKK GKWGQNLKVL LLSSESGVDG LAQHRQTPQA ADGYLAIPFE MGELAALSHG 130 140 150 160 170 180 IVPPGTDDTG ASLDAALNGT REAPPPMPPS LKAAAGGPPK LPKRERRSAM TEEDRAFLDR 190 200 210 220 230 240 TFQSIADRKA ELLAESRQLK RPPPRRELMG TPEGKIQILR DELKTREAQL ARLSEIWNVR 250 260 270 280 290 300 ERELLSGEDR IHEKDVELQG LKMQVDDLLR RFNEAQQATI QKEREHGATV DDLLLQKFSA 310 320 330 340 350 360 EKDLIEVVAS KEKDINLLRR EVSRAEEELS RRAGELEHGR NEYDKLEKHL GVVTLEFEVK 370 380 390 400 410 420 EQKLQDTVLA NEGEIARLTK RGDDFEAELN RTISERDQRF AELDGEIQAL QERLQQTEQE 430 440 450 460 470 480 RDTTVRGLEA RAARAEEHGT QADAEIHRLN AERDALEAKL SQQVADLEAD LARTMGERDQ 490 500 510 520 530 540 LRLDKDAQEA ELTQRIEERD AKLGTLEREL SETIARNEHT EAELNANIQQ QLERIGELEG 550 560 570 580 590 600 EVEAVKTHLE DRENELTAEL QALGQAKDEL ETDLNDRLQA LSQAKDALEA DLSRQLEELR 610 620 630 640 650 660 SAKAELEADL TGQIQALTSQ LEETQRQLDD SQRTGEQLSA RVAQLEDTVS QRESTIESLQ 670 680 690 700 710 720 GDVAARDQRI SELSGDLEAT SQTLAQTQQT LAQTEQQLAD TQNTLASTEG ALAETRGELD 730 740 750 760 770 780 ATSQTLQQTQ QTLAQTEGAL AETRGELDAT SQTLAQTQQT LAQTEQQLAD TQNTLASTEG 790 800 810 820 830 840 TLAETRGELE ATSQTLQQTH AALEDTRGAL QETSDTLAHT TRERDQRIAE LADLGAAKDA 850 860 870 880 890 900 LEQELTGQIG HLRSELSETQ GNYEAERAAH EKLAAESSAH IGDLTSERDG LRSELEATSQ 910 920 930 940 950 960 TLEQTHGQLA ATRDALAREQ HAHQESRKAA ASTQTTLEGQ LAEARAHGED LGEHLTLTKH 970 980 990 1000 1010 1020 ELGTRVAELT QLTATLAQTE NTRAHLEERL HTLTEESQRR EELLQNDLTQ KGTELSDTLR 1030 1040 1050 1060 1070 1080 KLTHVTQEKM RQAEVLNREV ATRTEQLKAM EAKLQTQATE ARRQAEGLGQ QITGLNEQLE 1090 1100 1110 1120 1130 1140 QGRKALAGRE DQLRAAGAAQ QKLTAERDGL AGQLQQAEAR LQQQAQQANQ ERADAKRAAD 1150 1160 1170 1180 1190 1200 ELAAKLAKTE QRITQFAQDA QTQATEADAR AKDLQGQLSA RAKKIQDLEL AVENAQGAKS 1210 1220 1230 1240 1250 1260 RAEKELNAKV AAAESKAHEA STRLAAAQKE RKDLEARHAK EQEDLAAKQK AELERRDAIK 1270 1280 1290 1300 1310 1320 AQEVARLQQS VQEKSKALKV AELELARYKS KSATTATPAK AAAKPAAAED DELAVRTQLN 1330 1340 1350 1360 1370 1380 QVIAPAAAAQ APAPAKKPAA KPAAQAPAKK APAPAPAPPA ALSDESEPTD RTLVIQLPTA 1390 KEDDDWTALV DELDK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"AglZ is a filament-forming coiled-coil protein required for adventurous gliding motility of Myxococcus xanthus." Yang R., Bartle S., Otto R., Stassinopoulos A.G., Rogers M., Plamann L., Hartzell P.L. J. Bacteriol. 186:6168-6178(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH MGLA.
[2]	"Evolution of sensory complexity recorded in a myxobacterial genome." Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B. Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DK 1622.
[3]	"Evidence that focal adhesion complexes power bacterial gliding motility." Mignot T., Shaevitz J.W., Hartzell P.L., Zusman D.R. Science 315:853-856(2007) [PubMed] [Europe PMC] [Abstract] Cited for: ROLE IN A-TYPE GLIDING MOTILITY, SUBCELLULAR LOCATION.

Web resources

Protein Spotlight

Slip sliding away - Issue 81 of April 2007

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY487937 Genomic DNA. Translation: AAR39422.1. CP000113 Genomic DNA. Translation: ABF92300.1.
RefSeq	YP_631200.1. NC_008095.1.
3D structure databases
ProteinModelPortal	Q1D823.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q1D823. 10 interactions.
STRING	246197.MXAN_2991.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF92300; ABF92300; MXAN_2991.
GeneID	4106990.
KEGG	mxa:MXAN_2991.
PATRIC	22648533. VBIMyxXan43560_2946.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG12793.
OMA	RERRSAM.
ProtClustDB	CLSK946360.
Enzyme and pathway databases
BioCyc	MXAN246197:GIWU-2964-MONOMER.
Family and domain databases
InterPro	IPR011006. CheY-like_superfamily. IPR001789. Sig_transdc_resp-reg_receiver. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGLZ_MYXXD

Accession

Primary (citable) accession number: Q1D823
Secondary accession number(s): Q6RW49

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program