Q1D556 (Q1D556_MYXXD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase HAMAP MF_01023
EC=2.6.1.9 HAMAP MF_01023

Alternative name(s):
Imidazole acetol-phosphate transaminase HAMAP MF_01023

Gene names

Name:	hisC HAMAP MF_01023
Ordered Locus Names:	MXAN_4038

Organism

Myxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP] EMBL ABF90946.1

Taxonomic identifier

246197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. HAMAP MF_01023

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP MF_01023
Ligand	Pyridoxal phosphate HAMAP MF_01023
Molecular function	Aminotransferase HAMAP MF_01023 EMBL ABF90946.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	225	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_01023

Sequences

	Sequence		Length	Mass (Da)
	Q1D556 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 465D754BF28832AE	FASTA	363	40,037
	10 20 30 40 50 60 MRPLVPTHVE TLKPYVPGKP IEETEREFGL KGVIKLASNE NPLGPSPRAV EAMRNVSGAT 70 80 90 100 110 120 HLYPDATSFH LVRKLAAHVD VKPEQVVLGS GSNELIELLI RTFTTPEDEI LLCQGSFSAY 130 140 150 160 170 180 RISAQAHGRP FVEMPMREGF LYDLEAMAKA ITPRTRMVFL ANPDNPTGTA FSRDALTRFL 190 200 210 220 230 240 AAVPPEVLVV HDEAYCEFVE WPEYTSAVPL VGQHPNLVAL RTFSKIHGLA GVRLGYGIMD 250 260 270 280 290 300 ARLAAYLHRT RMPFNLTVLA QAAGLAALED TEHVRRTREV NRAGLDYFAA ELPMLGGTLT 310 320 330 340 350 360 HSHANFVFVD FGRPAVALYE QLLRKGIIVR PFAGQGFPNH VRISVGTPAE NARCVQVLKE ILT

References

[1]

"Evolution of sensory complexity recorded in a myxobacterial genome." Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B. Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed: 17015832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000113 Genomic DNA. Translation: ABF90946.1.
RefSeq	YP_632217.1. NC_008095.1.
3D structure databases
ProteinModelPortal	Q1D556.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1D556.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4105626.
GenomeReviews	Gene locus MXAN_4038 in contig CP000113_GR.
KEGG	mxa:MXAN_4038.
PATRIC	22650649. VBIMyxXan43560_3987.
TIGR	MXAN_4038.
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	ENPLGMP.
PhylomeDB	Q1D556.
ProtClustDB	PRK02731.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1D556_MYXXD

Accession

Primary (citable) accession number: Q1D556

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)