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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
  4. Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100SubstrateUniRule annotation1
Active sitei109Proton acceptorUniRule annotation1
Metal bindingi129Monovalent cationUniRule annotation1
Binding sitei132ATPUniRule annotation1
Binding sitei184SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 13ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-4087-MONOMER
UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:MXAN_4151
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002675681 – 256Type III pantothenate kinaseAdd BLAST256

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi246197.MXAN_4151

Structurei

3D structure databases

ProteinModelPortaliQ1D4U7
SMRiQ1D4U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 110Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108194 Bacteria
COG1521 LUCA
HOGENOMiHOG000066025
KOiK03525
OMAiHEPWLTL
OrthoDBiPOG091H01V7

Family and domain databases

HAMAPiMF_01274 Pantothen_kinase_3, 1 hit
InterProiView protein in InterPro
IPR004619 Type_III_PanK
PANTHERiPTHR34265 PTHR34265, 1 hit
PfamiView protein in Pfam
PF03309 Pan_kinase, 1 hit
TIGRFAMsiTIGR00671 baf, 1 hit

Sequencei

Sequence statusi: Complete.

Q1D4U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAIDVGNT NTVLGVFEGR RLLDHWRVET STRRTSDEYG ILVRQLFTHR
60 70 80 90 100
GIDPMKVTAV VVSSVVPPLQ SNLEKMSERY FRVRPMFIGP GVKTGMPILY
110 120 130 140 150
DNPREVGADR IVNAVSAYER HHAGVLVVDF GTATTFDAVS PKGEYLGGCI
160 170 180 190 200
CPGINISMEA LFQNASKLPR VEFARPPHVI GRNTVHSMQA GLVYGYVGMV
210 220 230 240 250
DGICARMQAE LGFPVKVVAT GGLASLVASE SKAIHQVDEF LTLEGLRIIY

GRNHAS
Length:256
Mass (Da):27,982
Last modified:July 11, 2006 - v1
Checksum:i1A657C043CCE0603
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA Translation: ABF92916.1
RefSeqiWP_011554154.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF92916; ABF92916; MXAN_4151
KEGGimxa:MXAN_4151

Similar proteinsi

Entry informationi

Entry nameiCOAX_MYXXD
AccessioniPrimary (citable) accession number: Q1D4U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health