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Q1D393

- LPXB_MYXXD

UniProt

Q1D393 - LPXB_MYXXD

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciMXAN246197:GIWU-4682-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:MXAN_4718
    OrganismiMyxococcus xanthus (strain DK 1622)
    Taxonomic identifieri246197 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
    ProteomesiUP000002402: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383Lipid-A-disaccharide synthasePRO_0000255199Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi246197.MXAN_4718.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1D393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1D393-1 [UniParc]FASTAAdd to Basket

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    MTNPPRILVV AGEASGDTHA AELVAALRAR RPDLTFFGMG GARLAAQGVE    50
    LLFDAREVSV MGITEVLPRI PRILQILKGL AEAAAERKPD VAILVDIPDF 100
    NLRLAKKLKA LGVPVAYYVS PMIWAWRRGR VRTIKRLVDR MLCILPFEED 150
    FYREAGVSAR YVGSPVVEQV PSPDTATAFR ERLGLSKDAP TLALLPGSRM 200
    GEIRRLLPDM VEAAKRLSAE RPGLQVVVPL APTIDREEIT SRFEGSGVTP 250
    ILVEGRAPEV VGASDAAVVA SGTAVLEAGL MQRPLVVVYR VSLITYWVGR 300
    LMLKVAFVSL INLLAGRRVV PELLQGEMTP ERIAEEVRRV WIPGAPREEM 350
    LQGLAEMRGR LGETGAATRA AESVLELLPP GRV 383
    Length:383
    Mass (Da):41,692
    Last modified:July 11, 2006 - v1
    Checksum:i5E6B9BC19CBAEDA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000113 Genomic DNA. Translation: ABF90745.1.
    RefSeqiYP_632880.1. NC_008095.1.

    Genome annotation databases

    EnsemblBacteriaiABF90745; ABF90745; MXAN_4718.
    GeneIDi4104078.
    KEGGimxa:MXAN_4718.
    PATRICi22651997. VBIMyxXan43560_4652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000113 Genomic DNA. Translation: ABF90745.1 .
    RefSeqi YP_632880.1. NC_008095.1.

    3D structure databases

    ProteinModelPortali Q1D393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 246197.MXAN_4718.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF90745 ; ABF90745 ; MXAN_4718 .
    GeneIDi 4104078.
    KEGGi mxa:MXAN_4718.
    PATRICi 22651997. VBIMyxXan43560_4652.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci MXAN246197:GIWU-4682-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DK 1622.

    Entry informationi

    Entry nameiLPXB_MYXXD
    AccessioniPrimary (citable) accession number: Q1D393
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3