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Q1D393

- LPXB_MYXXD

UniProt

Q1D393 - LPXB_MYXXD

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMXAN246197:GIWU-4682-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:MXAN_4718
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
ProteomesiUP000002402: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_0000255199Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_4718.

Structurei

3D structure databases

ProteinModelPortaliQ1D393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1D393-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNPPRILVV AGEASGDTHA AELVAALRAR RPDLTFFGMG GARLAAQGVE
60 70 80 90 100
LLFDAREVSV MGITEVLPRI PRILQILKGL AEAAAERKPD VAILVDIPDF
110 120 130 140 150
NLRLAKKLKA LGVPVAYYVS PMIWAWRRGR VRTIKRLVDR MLCILPFEED
160 170 180 190 200
FYREAGVSAR YVGSPVVEQV PSPDTATAFR ERLGLSKDAP TLALLPGSRM
210 220 230 240 250
GEIRRLLPDM VEAAKRLSAE RPGLQVVVPL APTIDREEIT SRFEGSGVTP
260 270 280 290 300
ILVEGRAPEV VGASDAAVVA SGTAVLEAGL MQRPLVVVYR VSLITYWVGR
310 320 330 340 350
LMLKVAFVSL INLLAGRRVV PELLQGEMTP ERIAEEVRRV WIPGAPREEM
360 370 380
LQGLAEMRGR LGETGAATRA AESVLELLPP GRV
Length:383
Mass (Da):41,692
Last modified:July 11, 2006 - v1
Checksum:i5E6B9BC19CBAEDA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000113 Genomic DNA. Translation: ABF90745.1.
RefSeqiYP_632880.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF90745; ABF90745; MXAN_4718.
GeneIDi4104078.
KEGGimxa:MXAN_4718.
PATRICi22651997. VBIMyxXan43560_4652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000113 Genomic DNA. Translation: ABF90745.1 .
RefSeqi YP_632880.1. NC_008095.1.

3D structure databases

ProteinModelPortali Q1D393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 246197.MXAN_4718.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF90745 ; ABF90745 ; MXAN_4718 .
GeneIDi 4104078.
KEGGi mxa:MXAN_4718.
PATRICi 22651997. VBIMyxXan43560_4652.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci MXAN246197:GIWU-4682-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DK 1622.

Entry informationi

Entry nameiLPXB_MYXXD
AccessioniPrimary (citable) accession number: Q1D393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3