Q1D393 (LPXB_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	MXAN_4718

Organism

Myxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]

Taxonomic identifier

246197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	383 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 383	383	Lipid-A-disaccharide synthase HAMAP MF_00392		PRO_0000255199

Sequences

	Sequence		Length	Mass (Da)
	Q1D393 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 5E6B9BC19CBAEDA3	FASTA	383	41,692
	10 20 30 40 50 60 MTNPPRILVV AGEASGDTHA AELVAALRAR RPDLTFFGMG GARLAAQGVE LLFDAREVSV 70 80 90 100 110 120 MGITEVLPRI PRILQILKGL AEAAAERKPD VAILVDIPDF NLRLAKKLKA LGVPVAYYVS 130 140 150 160 170 180 PMIWAWRRGR VRTIKRLVDR MLCILPFEED FYREAGVSAR YVGSPVVEQV PSPDTATAFR 190 200 210 220 230 240 ERLGLSKDAP TLALLPGSRM GEIRRLLPDM VEAAKRLSAE RPGLQVVVPL APTIDREEIT 250 260 270 280 290 300 SRFEGSGVTP ILVEGRAPEV VGASDAAVVA SGTAVLEAGL MQRPLVVVYR VSLITYWVGR 310 320 330 340 350 360 LMLKVAFVSL INLLAGRRVV PELLQGEMTP ERIAEEVRRV WIPGAPREEM LQGLAEMRGR 370 380 LGETGAATRA AESVLELLPP GRV

References

[1]

"Evolution of sensory complexity recorded in a myxobacterial genome." Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B. Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed: 17015832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DK 1622.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000113 Genomic DNA. Translation: ABF90745.1.
RefSeq	YP_632880.1. NC_008095.1.
3D structure databases
ProteinModelPortal	Q1D393.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1D393.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4104078.
GenomeReviews	Gene locus MXAN_4718 in contig CP000113_GR.
KEGG	mxa:MXAN_4718.
PATRIC	22651997. VBIMyxXan43560_4652.
TIGR	MXAN_4718.
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	AEFAFIC.
PhylomeDB	Q1D393.
ProtClustDB	CLSK946302.
Enzyme and pathway databases
BioCyc	MXAN246197:MXAN_4718-MONOMER.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_MYXXD

Accession

Primary (citable) accession number: Q1D393

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program