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Q1D2J4 (RUVC_MYXXD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:MXAN_4973
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP]
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_1000071033

Sites

Metal binding71Magnesium By similarity
Metal binding671Magnesium By similarity
Metal binding1411Magnesium By similarity
Metal binding1441Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1D2J4 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 90121E16C2AE4515

FASTA19119,826
        10         20         30         40         50         60 
MRVLGVDPGS RFMGFGVVEE KRGRLVHVGH GVIKGDPALP LSDRLRDLHG ALTAALVKYR 

        70         80         90        100        110        120 
PAAVAVEGVF TFRNARSALV LGHARGVALL AAAQAGLPVF EYAPAKVKKA VGAGGADGKD 

       130        140        150        160        170        180 
AVARMVRTFL ELDASVLERA DASDALAVAL CHLNHGRAAV PAASASGKKR KGAAALLADR 

       190 
LAPAYRRPEA R 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000113 Genomic DNA. Translation: ABF86200.1.
RefSeqYP_633129.1. NC_008095.1.

3D structure databases

ProteinModelPortalQ1D2J4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246197.MXAN_4973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF86200; ABF86200; MXAN_4973.
GeneID4105281.
KEGGmxa:MXAN_4973.
PATRIC22652483. VBIMyxXan43560_4892.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012181.
KOK01159.
OMAYTALQMK.
OrthoDBEOG6RG044.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-4937-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVC_MYXXD
AccessionPrimary (citable) accession number: Q1D2J4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families