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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:MXAN_5607
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Transmembranei101 – 121HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 157HelicalUniRule annotationAdd BLAST21
Transmembranei181 – 201HelicalUniRule annotationAdd BLAST21
Transmembranei213 – 233HelicalUniRule annotationAdd BLAST21
Transmembranei268 – 288HelicalUniRule annotationAdd BLAST21
Transmembranei295 – 315HelicalUniRule annotationAdd BLAST21
Transmembranei320 – 340HelicalUniRule annotationAdd BLAST21
Transmembranei369 – 389HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003325391 – 392Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST392

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_5607.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1D0S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLLYEVIQ NSEAGRVLNF LRYPTFRIIA AGVFALLLGM LIGPKLIARL
60 70 80 90 100
RLKQHGQSNV REDTPDSHQK KKGTPTMGGA LILLCIAAGT LLFADLKSRA
110 120 130 140 150
VWVMLLLTLG YGFIGFLDDW LKLSKRNSKG LAGRKKMVLQ TFFFLVAVFG
160 170 180 190 200
LLTTWTLPDG SFGPTLLINT KLTLPFIPTR WFNPDLGWFY VFFAWIVVVG
210 220 230 240 250
TSNAVNLTDG LDGLAIVPTI VSAITFAVLC YVAGTTLSIA DYEVVGGASK
260 270 280 290 300
LVATPLYQYL GILQVPGGAE LAVFCAAIVG AGISFLWFNT YPASVFMGDI
310 320 330 340 350
GSLALGGALG GLAMLSKNEV VSAIIHGIFF AEILSVMIQV TSFKMTGKRV
360 370 380 390
FKMAPVHHHF ELKGMAEPKI IVRFWIVSIL CGGVALLSLK LR
Length:392
Mass (Da):42,590
Last modified:July 11, 2006 - v1
Checksum:i246E143F57DE29B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA. Translation: ABF91493.1.
RefSeqiWP_011555561.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF91493; ABF91493; MXAN_5607.
KEGGimxa:MXAN_5607.

Similar proteinsi

Entry informationi

Entry nameiMRAY_MYXXD
AccessioniPrimary (citable) accession number: Q1D0S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 11, 2006
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families