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Q1D0E5 (Q1D0E5_MYXXD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:MXAN_5741 EMBL ABF92512.1
OrganismMyxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP] EMBL ABF92512.1
Taxonomic identifier246197 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain101 – 297197ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding129 – 18456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2511Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2641Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2641Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
Q1D0E5 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 2131350D62A85130

FASTA32634,393
        10         20         30         40         50         60 
MGKRVGVLMG GWGEEREISL KTGEAVVAAL ESRGHQVTRI FAGPGLDRAL RAAELDVAFV 

        70         80         90        100        110        120 
ALHGRMGEDG RVQGLLELLE LPYTGSGVLA SALAMNKPFA KRFFRLHNLA TPHGYTVARE 

       130        140        150        160        170        180 
DAWRALALHG DLGFPCVVKP ACGGSSMGLA LVREPEALAF AVAQASRFGG EALVERYVAG 

       190        200        210        220        230        240 
REVTVGILGG QVLGSCEVAT PREGFDFDAK YKGGAAYFCP PRLSPTRVAN VEALALAAYR 

       250        260        270        280        290        300 
ALGCRGQARV DLMCSDTEND VVLEVNTLPG FTPTSLLPKI AARAGLDFAA LTERILALAT 

       310        320 
RDEAGVLEAP AVETPPDLGV PRRAVS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000113 Genomic DNA. Translation: ABF92512.1.
RefSeqYP_633878.1. NC_008095.1.

3D structure databases

ProteinModelPortalQ1D0E5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246197.MXAN_5741.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF92512; ABF92512; MXAN_5741.
GeneID4107203.
KEGGmxa:MXAN_5741.
PATRIC22654001. VBIMyxXan43560_5645.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMACLLEANT.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycMXAN246197:GIWU-5698-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1D0E5_MYXXD
AccessionPrimary (citable) accession number: Q1D0E5
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)