Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37S-adenosyl-L-methionineUniRule annotation1
Binding sitei62S-adenosyl-L-methionineUniRule annotation1
Binding sitei89S-adenosyl-L-methionineUniRule annotation1
Active sitei112By similarity1
Binding sitei112S-adenosyl-L-methionineUniRule annotation1
Binding sitei116SubstrateUniRule annotation1
Binding sitei148SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-5694-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:MXAN_5790
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002881861 – 206tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST206

Proteomic databases

PRIDEiQ1D096

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_5790

Structurei

3D structure databases

ProteinModelPortaliQ1D096
SMRiQ1D096
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
HOGENOMiHOG000003597
KOiK03439
OMAiGHALEYC
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q1D096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPRLLPEP VGLKFVTQET PPDWDAEFGF SGPLELEIGS GAGGHALEYC
60 70 80 90 100
RRHPEVRFVA FEWRKKYARD TQDRADKAGL RNLRVIESDA RFIVPRIFAP
110 120 130 140 150
DSLAAIHLQF PDPWWKRSHA KRAVIQPAFA ELLYGKLAPG GLFDMRTDVQ
160 170 180 190 200
DRGVTMLAIL ESVGFKNPLG SGVFHPYDPE EVPSTRERRY LASGEPVYRA

RLLKPA
Length:206
Mass (Da):23,312
Last modified:July 11, 2006 - v1
Checksum:i3CA68D7EBAA744DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA Translation: ABF88297.1
RefSeqiWP_011555741.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF88297; ABF88297; MXAN_5790
KEGGimxa:MXAN_5790

Similar proteinsi

Entry informationi

Entry nameiTRMB_MYXXD
AccessioniPrimary (citable) accession number: Q1D096
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health