Q1CZU4 (Q1CZU4_MYXXD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidylate synthase HAMAP MF_00008
Short name=TS HAMAP MF_00008
Short name=TSase HAMAP MF_00008
EC=2.1.1.45 HAMAP MF_00008

Gene names

Name:	thyA HAMAP MF_00008
Ordered Locus Names:	MXAN_5942

Organism

Myxococcus xanthus (strain DK 1622) [Complete proteome] [HAMAP] EMBL ABF93102.1

Taxonomic identifier

246197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008
Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008 SAAS SAAS023451
Pathway	Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008 SAAS SAAS023451
Subunit structure	Homodimer By similarity. HAMAP MF_00008 SAAS SAAS023451
Subcellular location	Cytoplasm By similarity HAMAP MF_00008.
Sequence similarities	Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. HAMAP MF_00008

Ontologies

Keywords
Biological process	Nucleotide biosynthesis SAAS SAAS023451 HAMAP MF_00008
Cellular component	Cytoplasm HAMAP MF_00008
Molecular function	Methyltransferase HAMAP MF_00008 SAAS SAAS023451 EMBL ABF93102.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	149	1	By similarity HAMAP MF_00008

Sequences

	Sequence		Length	Mass (Da)
	Q1CZU4 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: A5E80D20B06038A2	FASTA	267	29,998
	10 20 30 40 50 60 MGPMQPYLSL LDHVLHHGVK KGDRTGTGTL SVFGPQLRFD LTQGFPLLTT KKVHTKSILH 70 80 90 100 110 120 ELLWMLAGDT NVHTLQAQGV TIWDEWANAD GSLGPVYGHQ WRSWTAPNGE HIDQMKALVE 130 140 150 160 170 180 GLKKNPDSRR HIISAWNVAD LPSMKLPPCH VLFQFYVANG RLSCQLYQRS ADLFLGLPFN 190 200 210 220 230 240 IASYSLLTMM VAQVTGLQAH EFIHTVGDAH LYLNHVEQAK TQLSREPRPL PRIHINPEVT 250 260 DLFAFKYEDF TLEGYDPHPA IKAPVAV

References

[1]

"Evolution of sensory complexity recorded in a myxobacterial genome." Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J., Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G., Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A. , Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B. Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006) [PubMed: 17015832] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000113 Genomic DNA. Translation: ABF93102.1.
RefSeq	YP_634079.1. NC_008095.1.
3D structure databases
ProteinModelPortal	Q1CZU4.
SMR	Q1CZU4. Positions 4-267.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1CZU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4107799.
GenomeReviews	Gene locus MXAN_5942 in contig CP000113_GR.
KEGG	mxa:MXAN_5942.
PATRIC	22654415. VBIMyxXan43560_5852.
TIGR	MXAN_5942.
Phylogenomic databases
eggNOG	COG0207.
HOGENOM	HBG588098.
OMA	RMALAPC.
PhylomeDB	Q1CZU4.
Family and domain databases
HAMAP	MF_00008. Thymidy_synth_bact. [Tree]
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. IPR020940. Thymidylate_synthase_AS. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KO	K00560.
PANTHER	PTHR11549:SF2. Thymidylat_synth_C. 1 hit.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMs	TIGR03284. Thym_sym. 2 hits.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1CZU4_MYXXD

Accession

Primary (citable) accession number: Q1CZU4

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)