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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-5968-MONOMER
UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:MXAN_6064
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000186111 – 212N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST212

Proteomic databases

PRIDEiQ1CZH4

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_6064

Structurei

3D structure databases

ProteinModelPortaliQ1CZH4
SMRiQ1CZH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB Bacteria
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG091H01PA

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

Q1CZH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRVKVCGV TRLSDAVAAW EAGVDALGLN FYPKSPRYLD LPTAAALART
60 70 80 90 100
RPPLGTVLGV FVNAAPDTIR ETVRACGLTA VQLHGDEPPE ACSGYGVPVI
110 120 130 140 150
KALRVTGPED VVRARTYVGV GDVAGLLLDG AAPGYGGGGV GFDWSLVAGL
160 170 180 190 200
AGSGVPVLVA GGLRPSNVAE AVRATRPYGV DVASGVESAP GIKDVEAVRA
210
FVRAAKSINL WE
Length:212
Mass (Da):21,633
Last modified:July 11, 2006 - v1
Checksum:iB9536A7906E8572D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA Translation: ABF91277.1
RefSeqiWP_011556013.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF91277; ABF91277; MXAN_6064
KEGGimxa:MXAN_6064

Entry informationi

Entry nameiTRPF_MYXXD
AccessioniPrimary (citable) accession number: Q1CZH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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