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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-6402-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:MXAN_6514
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei113 – 133HelicalUniRule annotationAdd BLAST21
Transmembranei151 – 171HelicalUniRule annotationAdd BLAST21
Transmembranei190 – 210HelicalUniRule annotationAdd BLAST21
Transmembranei220 – 240HelicalUniRule annotationAdd BLAST21
Transmembranei249 – 269HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002502461 – 297Undecaprenyl-diphosphataseAdd BLAST297

Proteomic databases

PRIDEiQ1CY86

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_6514

Structurei

3D structure databases

SMRiQ1CY86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q1CY86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLEAIVLG LVQGLTEFLP ISSTAHLRIA PELFGWRDPG AAYSAVIQLG
60 70 80 90 100
TVAAVLIYFR KDIVSLVAAF FRGLARREPF GTLEARLAWF VLVGTLPVGI
110 120 130 140 150
AGLTLKKFIE NEFRSLYVIS GSLIVLALIL LVVEKRASHQ RTLADMRWKD
160 170 180 190 200
GILIGMWQAL ALIPGASRSG TTLTGGLSLG LKREDAARYS FLLSIPATTL
210 220 230 240 250
AGVFELKHLL EAETRPSAMA LWVGTLVAFA SGMAAIAWLL RFLRTRTTLV
260 270 280 290
FVVYRVALGV LLLVLLQTGK LSPMSGVENV EVPGEPGAPP VEKQITD
Length:297
Mass (Da):32,107
Last modified:July 11, 2006 - v1
Checksum:i0E2AF378FD6FD8F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA Translation: ABF89199.1
RefSeqiWP_011556445.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF89199; ABF89199; MXAN_6514
KEGGimxa:MXAN_6514

Similar proteinsi

Entry informationi

Entry nameiUPPP_MYXXD
AccessioniPrimary (citable) accession number: Q1CY86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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