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Protein

Chemotaxis response regulator protein-glutamate methylesterase 5

Gene

cheB5

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169UniRule annotation1
Active sitei196UniRule annotation1
Active sitei292UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 5UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB5UniRule annotation
Ordered Locus Names:MXAN_6959
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642961 – 348Chemotaxis response regulator protein-glutamate methylesterase 5Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_6959.

Structurei

3D structure databases

ProteinModelPortaliQ1CWZ9.
SMRiQ1CWZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 125Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini157 – 348CheB-type methylesteraseUniRule annotationAdd BLAST192

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiHPSVDVL.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CWZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVVSPIRVL VVDDSAFARK VLRQVLSSAE GLEVVGVARD GLDALEKVAE
60 70 80 90 100
LSPDVLTLDL VMPGLDGLGV LRALASSAAA PRVVVVSSAG EESELAVAAL
110 120 130 140 150
QAGAVELVNK PTALATERLY ELGGELVAKV RTAAGAVARA PPEPAPSPEA
160 170 180 190 200
TSAPVARAAA KSLVVVGTST GGPQALTRLL SELPVDFPAP LALALHIPTG
210 220 230 240 250
YTEAVARRLN AHCALEVFEA VDGLELRPGR VVLARSGQHL KLERHGPVTL
260 270 280 290 300
ARLDRQPLRT AHHPSVDVLF ESAARSWGSD VVGLVLTGMG DDGVAGARAI
310 320 330 340
REAGGTVLTE SESSCVVYGM PRAVKEAGLA TDSAPLEGML ALLRRHVR
Length:348
Mass (Da):35,939
Last modified:July 11, 2006 - v1
Checksum:iAB200C532B6FD00E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000113 Genomic DNA. Translation: ABF87336.1.
RefSeqiWP_011556880.1. NC_008095.1.

Genome annotation databases

EnsemblBacteriaiABF87336; ABF87336; MXAN_6959.
KEGGimxa:MXAN_6959.

Similar proteinsi

Entry informationi

Entry nameiCHEB5_MYXXD
AccessioniPrimary (citable) accession number: Q1CWZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 11, 2006
Last modified: November 22, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome