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Q1CV80

- LSPA_HELPH

UniProt

Q1CV80 - LSPA_HELPH

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Protein
Lipoprotein signal peptidase
Gene
lspA, HPAG1_0075
Organism
Helicobacter pylori (strain HPAG1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051 By similarity
Active sitei131 – 1311 By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciHPYL357544:GH1F-81-MONOMER.
    UniPathwayiUPA00665.

    Protein family/group databases

    MEROPSiA08.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoprotein signal peptidase (EC:3.4.23.36)
    Alternative name(s):
    Prolipoprotein signal peptidase
    Signal peptidase II
    Short name:
    SPase II
    Gene namesi
    Name:lspA
    Ordered Locus Names:HPAG1_0075
    OrganismiHelicobacter pylori (strain HPAG1)
    Taxonomic identifieri357544 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008835: Chromosome

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei38 – 5821Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei59 – 7921Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei84 – 10421Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei122 – 14221Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157Lipoprotein signal peptidaseUniRule annotation
    PRO_0000289391Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357544.HPAG1_0075.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A8 family.

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0597.
    HOGENOMiHOG000096992.
    KOiK03101.
    OMAiFIIDQNI.
    OrthoDBiEOG686NMZ.

    Family and domain databases

    HAMAPiMF_00161. LspA.
    InterProiIPR001872. Peptidase_A8.
    [Graphical view]
    PfamiPF01252. Peptidase_A8. 1 hit.
    [Graphical view]
    PRINTSiPR00781. LIPOSIGPTASE.
    TIGRFAMsiTIGR00077. lspA. 1 hit.
    PROSITEiPS00855. SPASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1CV80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKTTKKSLL VFMGGFFLIF GVDQAIKYAI LEGFRYESLM VDIVLVFNKG    50
    VAFSLLSFLE GGLKYLQILL ILGLFIFLIR QIELFKTHAI EFGMVFGAGV 100
    SNVLDRFVHG GVVDYVYYHY GFDFAIFNFA DVMIDVGVGV LLLRQFFFKQ 150
    KQNKIKA 157
    Length:157
    Mass (Da):17,895
    Last modified:July 11, 2006 - v1
    Checksum:i102B1B0793D92F80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000241 Genomic DNA. Translation: ABF84142.1.
    RefSeqiYP_626816.1. NC_008086.1.

    Genome annotation databases

    EnsemblBacteriaiABF84142; ABF84142; HPAG1_0075.
    GeneIDi4099024.
    KEGGihpa:HPAG1_0075.
    PATRICi20601448. VBIHelPyl56048_0078.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000241 Genomic DNA. Translation: ABF84142.1 .
    RefSeqi YP_626816.1. NC_008086.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 357544.HPAG1_0075.

    Protein family/group databases

    MEROPSi A08.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF84142 ; ABF84142 ; HPAG1_0075 .
    GeneIDi 4099024.
    KEGGi hpa:HPAG1_0075.
    PATRICi 20601448. VBIHelPyl56048_0078.

    Phylogenomic databases

    eggNOGi COG0597.
    HOGENOMi HOG000096992.
    KOi K03101.
    OMAi FIIDQNI.
    OrthoDBi EOG686NMZ.

    Enzyme and pathway databases

    UniPathwayi UPA00665 .
    BioCyci HPYL357544:GH1F-81-MONOMER.

    Family and domain databases

    HAMAPi MF_00161. LspA.
    InterProi IPR001872. Peptidase_A8.
    [Graphical view ]
    Pfami PF01252. Peptidase_A8. 1 hit.
    [Graphical view ]
    PRINTSi PR00781. LIPOSIGPTASE.
    TIGRFAMsi TIGR00077. lspA. 1 hit.
    PROSITEi PS00855. SPASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression."
      Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.
      Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HPAG1.

    Entry informationi

    Entry nameiLSPA_HELPH
    AccessioniPrimary (citable) accession number: Q1CV80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 11, 2006
    Last modified: May 14, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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