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Q1CUI3

- SYR_HELPH

UniProt

Q1CUI3 - SYR_HELPH

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Protein

Arginine--tRNA ligase

Gene
argS, HPAG1_0322
Organism
Helicobacter pylori (strain HPAG1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL357544:GH1F-331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:HPAG1_0322
OrganismiHelicobacter pylori (strain HPAG1)
Taxonomic identifieri357544 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008835: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Arginine--tRNA ligaseUniRule annotationPRO_1000018041Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi357544.HPAG1_0322.

Structurei

3D structure databases

ProteinModelPortaliQ1CUI3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi119 – 12911"HIGH" regionUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiIRNTIND.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1CUI3-1 [UniParc]FASTAAdd to Basket

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MHTLIKGVLE EILEEEVIIE YPKDREHGHY ATPIAFNLAK VFKKSPLVIA    50
EELALKISTH EKTQGLFDSI VACKGYINFT LSLDLLERFT QKALELKEQF 100
GSQIKSERSQ KIFLEFVSAN PTGPLHIGHA RGAVFGDSLA KIARFLGHEV 150
LCEYYVNDMG SQIRLLGLSV WLAYREHVLK ENVTYPEVFY KGEYIIEIAK 200
KANNDLEPSL FKENEETIIE VLSGYAKDLM LLEIKDNLDA LGIHFDSYAS 250
EKEIFKHKDA VFERLEKANA LYEKDSKIWL KSSLYQDESD RVLIKEDKSY 300
TYLTGDIVYH DEKFKQDYTK YINIWGADHH GYIARVKASL EFLGYDSNKL 350
EVLLAQMVRL LKDNEPYKMS KRAGNFILIK DVIDDVGKDA LRFIFLSKRL 400
DTHLEFDVNT LKKQDSSNPI YYIHYANSRI HTMLEKSPFS KEEVLQTPLK 450
NLNAEEKYLL FSTLSLPKAI ESSFEEYGLQ KMCEYAKTLA SEFHRFYNAG 500
KILDTPKAKE LLKICLMVSL SLTNAFKLLG IEIKTKISAK D 541
Length:541
Mass (Da):62,280
Last modified:July 11, 2006 - v1
Checksum:i24D0310D2CC97BDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000241 Genomic DNA. Translation: ABF84389.1.
RefSeqiWP_000557175.1. NC_008086.1.
YP_627063.1. NC_008086.1.

Genome annotation databases

EnsemblBacteriaiABF84389; ABF84389; HPAG1_0322.
GeneIDi4098521.
KEGGihpa:HPAG1_0322.
PATRICi20601975. VBIHelPyl56048_0338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000241 Genomic DNA. Translation: ABF84389.1 .
RefSeqi WP_000557175.1. NC_008086.1.
YP_627063.1. NC_008086.1.

3D structure databases

ProteinModelPortali Q1CUI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357544.HPAG1_0322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF84389 ; ABF84389 ; HPAG1_0322 .
GeneIDi 4098521.
KEGGi hpa:HPAG1_0322.
PATRICi 20601975. VBIHelPyl56048_0338.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247214.
KOi K01887.
OMAi IRNTIND.
OrthoDBi EOG6JB13C.

Enzyme and pathway databases

BioCyci HPYL357544:GH1F-331-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression."
    Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HPAG1.

Entry informationi

Entry nameiSYR_HELPH
AccessioniPrimary (citable) accession number: Q1CUI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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