Q1CUI3 (SYR_HELPH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	HPAG1_0322

Organism

Helicobacter pylori (strain HPAG1) [Complete proteome] [HAMAP]

Taxonomic identifier

357544 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 541	541	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_1000018041
Regions
	Motif	119 – 129	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q1CUI3 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 24D0310D2CC97BDD	FASTA	541	62,280
	10 20 30 40 50 60 MHTLIKGVLE EILEEEVIIE YPKDREHGHY ATPIAFNLAK VFKKSPLVIA EELALKISTH 70 80 90 100 110 120 EKTQGLFDSI VACKGYINFT LSLDLLERFT QKALELKEQF GSQIKSERSQ KIFLEFVSAN 130 140 150 160 170 180 PTGPLHIGHA RGAVFGDSLA KIARFLGHEV LCEYYVNDMG SQIRLLGLSV WLAYREHVLK 190 200 210 220 230 240 ENVTYPEVFY KGEYIIEIAK KANNDLEPSL FKENEETIIE VLSGYAKDLM LLEIKDNLDA 250 260 270 280 290 300 LGIHFDSYAS EKEIFKHKDA VFERLEKANA LYEKDSKIWL KSSLYQDESD RVLIKEDKSY 310 320 330 340 350 360 TYLTGDIVYH DEKFKQDYTK YINIWGADHH GYIARVKASL EFLGYDSNKL EVLLAQMVRL 370 380 390 400 410 420 LKDNEPYKMS KRAGNFILIK DVIDDVGKDA LRFIFLSKRL DTHLEFDVNT LKKQDSSNPI 430 440 450 460 470 480 YYIHYANSRI HTMLEKSPFS KEEVLQTPLK NLNAEEKYLL FSTLSLPKAI ESSFEEYGLQ 490 500 510 520 530 540 KMCEYAKTLA SEFHRFYNAG KILDTPKAKE LLKICLMVSL SLTNAFKLLG IEIKTKISAK D

References

[1]

"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression." Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HPAG1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000241 Genomic DNA. Translation: ABF84389.1.
RefSeq	YP_627063.1. NC_008086.1.
3D structure databases
ProteinModelPortal	Q1CUI3.
ModBase	Search...
Protein-protein interaction databases
STRING	357544.HPAG1_0322.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABF84389; ABF84389; HPAG1_0322.
GeneID	4098521.
KEGG	hpa:HPAG1_0322.
PATRIC	20601975. VBIHelPyl56048_0338.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247214.
KO	K01887.
OMA	HTSANPN.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	HPYL357544:GH1F-366-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_HELPH

Accession

Primary (citable) accession number: Q1CUI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program