Q1CUA3 (ACSA_HELPH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	HPAG1_0402

Organism

Helicobacter pylori (strain HPAG1) [Complete proteome] [HAMAP]

Taxonomic identifier

357544 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 662	662	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000065293
Sites
	Active site	527	1	By similarity
Amino acid modifications
	Modified residue	623	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1CUA3 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: CB5AFE4363E27CE1	FASTA	662	75,029
	10 20 30 40 50 60 MQLDDDLEFA KKIFNPNRAF AKQARIKNMC EYKDLVHEAN EDYEHFWGEL AKQKLTWFKP 70 80 90 100 110 120 FDKVLNSDNA PFFKWFENGK INVSYNCIDR HLKDKKNKVA IIFEGEMGDY NVITYRKLHS 130 140 150 160 170 180 EVNKTANLLK NEFNVKKGDR VIIYMPMIVE SVYMMLACAR IGAIHSIVFA GFSPEALRDR 190 200 210 220 230 240 INDAQAKLVI TADGTFRKGK PYMLKPALDK ALENNACPSV EKALIVIRNA KEIDYVRGRD 250 260 270 280 290 300 FVYNEMVNYQ SDKCEPEMMD SEDPLFLLYT SGSTGKPKGV QHSNAGYLLW AQMTMEWVFD 310 320 330 340 350 360 IRDNDNFWCT ADIGWITGHT YVVYGPLACG ATTLILEGTM SYPDYGRWWR MIEEYRVDKF 370 380 390 400 410 420 YTSPTAIRML HAKGENEPLK YNLESLKVLG TVGEPINPTA WKWFYEKIGN SKCSIVDTWW 430 440 450 460 470 480 QTETGGHIIS PLPGATPIRA SCATLPLPGI HAEVLNEDGT KTKPGEQGFL CITKPWPSMV 490 500 510 520 530 540 RNIWGDEKRY IDSYFSQIKL NGEYVYLSGD GAIVDENGYI TIIGRTDDIV NVSGHRIGTA 550 560 570 580 590 600 EVESAISKHE MVVECAVVGI PDTIKGEGLF AFVVLCDGAK CNLGESLELL KEMNHILSVE 610 620 630 640 650 660 IGKIAKLDNV MYVPGLPKTR SGKIMRRLLK SIAKKEPITQ DLSTLEDVNV VKEIMSIVQM EE

References

[1]

"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression." Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed: 16788065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HPAG1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000241 Genomic DNA. Translation: ABF84469.1.
RefSeq	YP_627143.1. NC_008086.1.
3D structure databases
ProteinModelPortal	Q1CUA3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1CUA3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4098779.
GenomeReviews	Gene locus HPAG1_0402 in contig CP000241_GR.
KEGG	hpa:HPAG1_0402.
PATRIC	20602141. VBIHelPyl56048_0419.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	KGKPYML.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	HPYL357544:HPAG1_0402-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_HELPH

Accession

Primary (citable) accession number: Q1CUA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program