Q1CTG9 (Q1CTG9_HELPH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897
Ordered Locus Names:	HPAG1_0686

Organism

Helicobacter pylori (strain HPAG1) [Complete proteome] [HAMAP]

Taxonomic identifier

357544 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	827 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q1CTG9 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 8599982FAD4C05F2	FASTA	827	92,775
	10 20 30 40 50 60 MQDHLVNETK NIVEVGIDSS IEESYLAYSM SVIIGRALPD ARDGLKPVHR RILYAMHELG 70 80 90 100 110 120 LTSKVAYKKS ARIVGDVIGK YHPHGDNAVY DALVRMAQDF SMRLELVDGQ GNFGSIDGDN 130 140 150 160 170 180 AAAMRYTEAR MTKASEEILR DIDKDTIDFV PNYDDTLKEP DILPSRLPNL LVNGANGIAV 190 200 210 220 230 240 GMATSIPPHR IDEIIDALAH VLENPNAELD EILEFVKGPD FPTGGIIYGK AGIIESYKTG 250 260 270 280 290 300 RGRVKVRAKV HVEKTKNKEI IVLDEMPFQT NKAKLVEQIS DLAREKQIEG ISEVRDESDR 310 320 330 340 350 360 EGIRVVIELK RDAMSEIVLN HLYKLTTMET TFSIILLAIY NKEPKIFTLL ELLRLFLNHR 370 380 390 400 410 420 KTIIIRRTIF ELEKAKARAH ILEGYLIALD NIDEIVQLIK TSPSPEAAKN ALMERFSLSE 430 440 450 460 470 480 IQSKAILEMR LQRLTGLERD KIKEEYQNLL ELIDDLNGIL KSEERLNEVV KTELLEVKEQ 490 500 510 520 530 540 FSSPRRTEIQ ESYENIDIED LIANEPMVVS ISYKGYVKRV DLKAYEKQNR GGKGKLSGST 550 560 570 580 590 600 YEDDFIENFF VANTHDILLF ITNKGQLYHL KVYKIPEASR IAMGKAIVNL ISLAPDEKIM 610 620 630 640 650 660 ATLSTKDFSD ERSLAFFTKK GVVKRTNLSE FGSNRSYSGI RAIVLDEGDE LVSAKVVDKN 670 680 690 700 710 720 AKHLLIASHL GIFIKFPLED VREIGRTTRG VKGIRLAEND FVVGAVVISD DGNKLLSVSE 730 740 750 760 770 780 NGLGKQTLAE AYREQNRGGK GIIGMRLTQK TGNLVSVISV DDENLDLMIL TASAKMIRVS 790 800 810 820 IKDIRETGRN ASGVKLINTA DKVMYVNSCP KEEEPENLEN TPAQLFE

References

[1]

"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression." Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed: 16788065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000241 Genomic DNA. Translation: ABF84753.1.
RefSeq	YP_627427.1. NC_008086.1.
3D structure databases
ProteinModelPortal	Q1CTG9.
SMR	Q1CTG9. Positions 34-490.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1CTG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4098695.
GenomeReviews	Gene locus HPAG1_0686 in contig CP000241_GR.
KEGG	hpa:HPAG1_0686.
PATRIC	20602728. VBIHelPyl56048_0712.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TSIPPHR.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1CTG9_HELPH

Accession

Primary (citable) accession number: Q1CTG9

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)