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Q1CTC3

- TRMB_HELPH

UniProt

Q1CTC3 - TRMB_HELPH

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Helicobacter pylori (strain HPAG1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241S-adenosyl-L-methionineUniRule annotation
Binding sitei149 – 1491S-adenosyl-L-methionineUniRule annotation
Binding sitei176 – 1761S-adenosyl-L-methionineUniRule annotation
Binding sitei232 – 2321SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPYL357544:GH1F-743-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:HPAG1_0732
OrganismiHelicobacter pylori (strain HPAG1)
Taxonomic identifieri357544 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008835: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393tRNA (guanine-N(7)-)-methyltransferasePRO_0000288158Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357544.HPAG1_0732.

Structurei

3D structure databases

ProteinModelPortaliQ1CTC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000252163.
KOiK03439.
OMAiSKYEARW.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1CTC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHFLAKLDF KPLKYPLIEG DFCFHKEFLS LKNPTKSCVY ASFKDRIFLL
60 70 80 90 100
QKIRRANDFL IKSEKTTPLK REILKQALRI YSQSFEVISH NLQENSKHAS
110 120 130 140 150
GKKALDLGTF EDFIQKNQAP ILAEIGFGSG RHLIELAKNN PTKTCLGIEI
160 170 180 190 200
HTPSIAQALK QIELLDLKNL HILQGDGRLI LESMPNYKCE KIFVHFPVPW
210 220 230 240 250
NEKKHRRVLS EKFLNEALRV LKPRGFLELR TDDGLYFEDS LKLALKNFQC
260 270 280 290 300
EIEIKKNAQI PVISKYEARW NKLKKDIYDL RIYSLELNET PFYNHAFDFS
310 320 330 340 350
FDTITMSEKS VGTILKTKKI IQEGYFVHVC NIYENKGDFL VELSMGDFDW
360 370 380 390
PVRLFVLLTE NQIFYLNKSP LKTLNNHKAH LLLQNILSQK GIG
Length:393
Mass (Da):45,707
Last modified:July 11, 2006 - v1
Checksum:iCC3EA4912DE0FD2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000241 Genomic DNA. Translation: ABF84799.1.
RefSeqiYP_627473.1. NC_008086.1.

Genome annotation databases

EnsemblBacteriaiABF84799; ABF84799; HPAG1_0732.
GeneIDi4098820.
KEGGihpa:HPAG1_0732.
PATRICi20602825. VBIHelPyl56048_0760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000241 Genomic DNA. Translation: ABF84799.1 .
RefSeqi YP_627473.1. NC_008086.1.

3D structure databases

ProteinModelPortali Q1CTC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357544.HPAG1_0732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF84799 ; ABF84799 ; HPAG1_0732 .
GeneIDi 4098820.
KEGGi hpa:HPAG1_0732.
PATRICi 20602825. VBIHelPyl56048_0760.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000252163.
KOi K03439.
OMAi SKYEARW.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci HPYL357544:GH1F-743-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression."
    Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HPAG1.

Entry informationi

Entry nameiTRMB_HELPH
AccessioniPrimary (citable) accession number: Q1CTC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3