Reviewed, UniProtKB/Swiss-Prot Q1CT68 (RIBA_HELPH)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase-2
    EC=3.5.4.25
Alternative name(s):
    GTP cyclohydrolase II

Gene names

Name:	ribA
Ordered Locus Names:	HPAG1_0787

Organism

Helicobacter pylori (strain HPAG1) [Complete proteome] [HAMAP]

Taxonomic identifier

357544 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate By similarity.
Catalytic activity	GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. HAMAP MF_00179
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; 6,7-dimethyl-8-(1-D-ribityl)lumazine from GTP: step 1/4. HAMAP MF_00179
Sequence similarities	Belongs to the GTP cyclohydrolase II family.

Ontologies

Keywords
Biological process	Riboflavin biosynthesis
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase II activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	GTP cyclohydrolase-2 HAMAP MF_00179		PRO_1000040568
Regions
	Nucleotide binding	50 – 54	5	GTP By similarity
	Nucleotide binding	92 – 94	3	GTP By similarity
Sites
	Active site	126	1	Proton acceptor Potential
	Active site	128	1	Nucleophile By similarity
	Metal binding	55	1	Zinc; catalytic By similarity
	Metal binding	66	1	Zinc; catalytic By similarity
	Metal binding	68	1	Zinc; catalytic By similarity
	Binding site	114	1	GTP By similarity
	Binding site	149	1	GTP By similarity
	Binding site	154	1	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1CT68-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: D752E2EA021428D9	FASTA	192	21,642
	10 20 30 40 50 60 MKRLEVSNQA KLPTQFGEFC IQCFREKGSS GSKDHLVVFT PNFSQNPLVR LHSECLTGDA 70 80 90 100 110 120 LGSQKCDCGG ALQMALERIS KEGGLVIYLR QEGRGIGLFN KVNAYALQDK GYDTIQANEM 130 140 150 160 170 180 IGFKDDERDY SIAGEILEYY RIKKMRLLTN NPKKIAALEK YAEVTRESLI VCANEHNQGY 190 LEVKKLKMGH LL

References

[1]

"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression." Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed: 16788065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000241 Genomic DNA. Translation: ABF84854.1.
RefSeq	YP_627528.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4099067.
GenomeReviews	Gene locus HPAG1_0787 in contig CP000241_GR.
KEGG	hpa:HPAG1_0787.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1CT68.
OMA	Q1CT68. YEIVEFI.
Enzyme and pathway databases
BioCyc	HPYL357544:HPAG1_0787-MON.
Family and domain databases
HAMAP	MF_00179. [Tree]
InterPro	IPR000926. GTP_CycHdrlase_II. [Graphical view]
Pfam	PF00925. GTP_cyclohydro2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00505. ribA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIBA_HELPH

Accession

Primary (citable) accession number: Q1CT68

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 11, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)