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Protein

Bifunctional protein HldE

Gene

hldE

Organism
Helicobacter pylori (strain HPAG1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.UniRule annotation
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.UniRule annotation

Catalytic activityi

D-glycero-beta-D-manno-heptose 7-phosphate + ATP = D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP.UniRule annotation
D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate.UniRule annotation

Pathwayi: ADP-L-glycero-beta-D-manno-heptose biosynthesis

This protein is involved in step 1 and 3 of the subpathway that synthesizes ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Bifunctional protein HldE (hldE)
  2. no protein annotated in this organism
  3. Bifunctional protein HldE (hldE)
  4. no protein annotated in this organism
This subpathway is part of the pathway ADP-L-glycero-beta-D-manno-heptose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate, the pathway ADP-L-glycero-beta-D-manno-heptose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei260UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi191 – 194ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL357544:G1G5Q-863-MONOMER
UniPathwayiUPA00356; UER00437
UPA00356; UER00439

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein HldEUniRule annotation
Including the following 2 domains:
D-beta-D-heptose 7-phosphate kinaseUniRule annotation (EC:2.7.1.167UniRule annotation)
Alternative name(s):
D-beta-D-heptose 7-phosphotransferaseUniRule annotation
D-glycero-beta-D-manno-heptose-7-phosphate kinaseUniRule annotation
D-beta-D-heptose 1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.70UniRule annotation)
Alternative name(s):
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferaseUniRule annotation
Gene namesi
Name:hldEUniRule annotation
Ordered Locus Names:HPAG1_0841
OrganismiHelicobacter pylori (strain HPAG1)
Taxonomic identifieri357544 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000008835 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002557631 – 463Bifunctional protein HldEAdd BLAST463

Proteomic databases

PRIDEiQ1CT14

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1CT14
SMRiQ1CT14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 315RibokinaseAdd BLAST315
Regioni334 – 463CytidylyltransferaseAdd BLAST130

Sequence similaritiesi

In the N-terminal section; belongs to the carbohydrate kinase PfkB family.UniRule annotation
In the C-terminal section; belongs to the cytidylyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000237584
KOiK03272
OMAiCDPKGKD
OrthoDBiPOG091H01Y4

Family and domain databases

CDDicd01172 RfaE_like, 1 hit
Gene3Di3.40.1190.20, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_01603 HldE, 1 hit
InterProiView protein in InterPro
IPR023030 Bifunc_HldE
IPR004821 Cyt_trans-like
IPR011611 PfkB_dom
IPR011913 RfaE_dom_I
IPR011914 RfaE_dom_II
IPR029056 Ribokinase-like
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
PF00294 PfkB, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR02198 rfaE_dom_I, 1 hit
TIGR02199 rfaE_dom_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q1CT14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILVIGDL IADYYLWGKS ERLSPEAPVP VLEVKKESKN LGGAANVANN
60 70 80 90 100
LISLKAKVFL CGVVGDDLEG KHFISALKAR EIDTSGILTD KTRCTTLKTR
110 120 130 140 150
IIAQNQQIVR VDKEIKDPLN ADLRKKLLDF FTEKIQEIDG VILSDYNKGV
160 170 180 190 200
LDFELTQKMI TLANQHHKLI LCDPKGKDYS KYSHASLITP NRAELEHALH
210 220 230 240 250
LKLDSHANLS KALQILKETY QIAMPLVTLS EQGIAFLEKG ELVNCPTIAK
260 270 280 290 300
EVYDVTGAGD TVIASLTLSL LESMSLKDAC EFANAAAAVV VGKMGSALAS
310 320 330 340 350
LEEIALILNQ THPKILPLEK LLETLEHHQQ KIVFTNGCFD LLHKGHASYL
360 370 380 390 400
QKAKALGDIL VVGLNSDNSI KRLKGNKRPI VSEKDRAFLL ASLSCVDYVV
410 420 430 440 450
VFEEDAPIKL IQALKPDILV KGADYLNKEV IGSEFAKETH LMEFEEGYST
460
SAIIEKIKRT HND
Length:463
Mass (Da):51,142
Last modified:July 11, 2006 - v1
Checksum:i7FA517BA48321AE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000241 Genomic DNA Translation: ABF84908.1
RefSeqiWP_000722994.1, NC_008086.1

Genome annotation databases

EnsemblBacteriaiABF84908; ABF84908; HPAG1_0841
KEGGihpa:HPAG1_0841

Similar proteinsi

Entry informationi

Entry nameiHLDE_HELPH
AccessioniPrimary (citable) accession number: Q1CT14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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