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Q1CSG4

- GLK_HELPH

UniProt

Q1CSG4 - GLK_HELPH

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Protein

Glucokinase

Gene
glk, HPAG1_1041
Organism
Helicobacter pylori (strain HPAG1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glucokinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL357544:GH1F-1067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glk
Ordered Locus Names:HPAG1_1041
OrganismiHelicobacter pylori (strain HPAG1)
Taxonomic identifieri357544 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008835: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336GlucokinaseUniRule annotationPRO_0000268775Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357544.HPAG1_1041.

Structurei

3D structure databases

ProteinModelPortaliQ1CSG4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0837.
HOGENOMiHOG000274469.
KOiK00845.
OMAiDKAPHSA.
OrthoDBiEOG64BQ47.

Family and domain databases

HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00749. glk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CSG4-1 [UniParc]FASTAAdd to Basket

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MPKTETYPRL LADIGGTNAR FGLEVAPRQI ECIEVLRCED FESLSDAVRF    50
YLSKCKESLK LHPIYGSFAV ATPIMGDFVQ MTNNHWTFSI ETTRQCLTLK 100
KLLVINDFVA QAYAISAMQE NDLAQIGGIK CEINAPKAIL GPGTGLGVST 150
LIQNSDGSLK VLPGEGGHVS FAPFDDLEIL VWQYARSKFN HVSAERFLSG 200
SGLVLIYEAL SKRKGLEKVA KLSKAELTPQ IISERALNGD YPICRLTLDT 250
FCSMLGTLAA DVALTLGARG GVYLCGGIIP RFIDYFKTSP FRARFETKGR 300
MGAFLASIPV HVVMKKTPGL DGAGIALENY LLHDKI 336
Length:336
Mass (Da):36,732
Last modified:July 11, 2006 - v1
Checksum:iEE941BE7411A51A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000241 Genomic DNA. Translation: ABF85108.1.
RefSeqiYP_627782.1. NC_008086.1.

Genome annotation databases

EnsemblBacteriaiABF85108; ABF85108; HPAG1_1041.
GeneIDi4099283.
KEGGihpa:HPAG1_1041.
PATRICi20603501. VBIHelPyl56048_1082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000241 Genomic DNA. Translation: ABF85108.1 .
RefSeqi YP_627782.1. NC_008086.1.

3D structure databases

ProteinModelPortali Q1CSG4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357544.HPAG1_1041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF85108 ; ABF85108 ; HPAG1_1041 .
GeneIDi 4099283.
KEGGi hpa:HPAG1_1041.
PATRICi 20603501. VBIHelPyl56048_1082.

Phylogenomic databases

eggNOGi COG0837.
HOGENOMi HOG000274469.
KOi K00845.
OMAi DKAPHSA.
OrthoDBi EOG64BQ47.

Enzyme and pathway databases

BioCyci HPYL357544:GH1F-1067-MONOMER.

Family and domain databases

HAMAPi MF_00524. Glucokinase.
InterProi IPR003836. Glucokinase.
[Graphical view ]
Pfami PF02685. Glucokinase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00749. glk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression."
    Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HPAG1.

Entry informationi

Entry nameiGLK_HELPH
AccessioniPrimary (citable) accession number: Q1CSG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3