Q1CS13 (AROE_HELPH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	HPAG1_1192

Organism

Helicobacter pylori (strain HPAG1) [Complete proteome] [HAMAP]

Taxonomic identifier

357544 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021291
Regions
	Nucleotide binding	125 – 129	5	NADP By similarity
Sites
	Active site	69	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1CS13 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 80224524A91F959D	FASTA	263	29,030
	10 20 30 40 50 60 MKLKSFGVLG NPIKHSKSPL IHNACFLTFQ KKLGFLGHYH PILLPLESHI KNEFLHLGLS 70 80 90 100 110 120 GANVTLPFKE RAFQICDKIK GIALECGAVN TLVLEDDELV GYNTDALGFW LSLGDEGYQS 130 140 150 160 170 180 ALILGSGGSA KALACELKKQ GLKVSVLNRS ARGLDFFQRL GCDCFMEPPK SAFDLIINAT 190 200 210 220 230 240 SASLNNELPL NKEVLKGYFK EGKLAYDLAY GFLTPFLSLA KELKTPFQDG KDMLIYQASL 250 260 SFEKFSASQI PYSKAFEVMR SVF

References

[1]

"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression." Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed: 16788065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HPAG1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000241 Genomic DNA. Translation: ABF85259.1.
RefSeq	YP_627933.1. NC_008086.1.
3D structure databases
ProteinModelPortal	Q1CS13.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1CS13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4098105.
GenomeReviews	Gene locus HPAG1_1192 in contig CP000241_GR.
KEGG	hpa:HPAG1_1192.
PATRIC	20603837. VBIHelPyl56048_1241.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	VVFGNPI.
ProtClustDB	PRK00258.
Enzyme and pathway databases
BioCyc	HPYL357544:HPAG1_1192-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_HELPH

Accession

Primary (citable) accession number: Q1CS13

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program