Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q1CRZ4 (NUOH_HELPH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit H

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit H
NDH-1 subunit H
Gene names
Name:nuoH
Ordered Locus Names:HPAG1_1211
OrganismHelicobacter pylori (strain HPAG1) [Complete proteome] [HAMAP]
Taxonomic identifier357544 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone By similarity. HAMAP-Rule MF_01350

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01350

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_01350.

Sequence similarities

Belongs to the complex I subunit 1 family.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329NADH-quinone oxidoreductase subunit H HAMAP-Rule MF_01350
PRO_0000298819

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane238 – 25821Helical; Potential
Transmembrane269 – 29123Helical; Potential
Transmembrane309 – 32921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q1CRZ4 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: F002A7CBF6F100F0

FASTA32936,328
        10         20         30         40         50         60 
MSAYIIETLI KILILVAVFS ALGGFATYIE RKVLAYFQRR LGPCYVGPFG LLQVAADGIK 

        70         80         90        100        110        120 
LFTKEDIIPQ GANKFIFTLA PIIAMVSAFV SMAPIPFFPN FTLFGYEIKP LISDINIGFL 

       130        140        150        160        170        180 
FFLAVGAAGI YAPILAGLAS NNKYSLIGSA RATIQLLSFE VVSTLTILAP LMVVGSLSLV 

       190        200        210        220        230        240 
EINHYQSGGF LDWLVFKQPL AFVLFLIASY AELNRTPFDL LEHEAEIVAG YCTEYSGLKW 

       250        260        270        280        290        300 
GMFFLAEYAH LFAFSFVISI VFFGGFNAWG FIPGGIAILI KAGFFVFLSM WVRATYPHVR 

       310        320 
PDQLMNMCWK IMLPLALLNI VLTGIIILI 

« Hide

References

[1]"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression."
Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HPAG1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000241 Genomic DNA. Translation: ABF85278.1.
RefSeqYP_627952.1. NC_008086.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357544.HPAG1_1211.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF85278; ABF85278; HPAG1_1211.
GeneID4098294.
KEGGhpa:HPAG1_1211.
PATRIC20603875. VBIHelPyl56048_1260.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1005.
HOGENOMHOG000228276.
KOK00337.
OMALDLGWKF.
OrthoDBEOG6B62B4.
ProtClustDBPRK06076.

Enzyme and pathway databases

BioCycHPYL357544:GH1F-1245-MONOMER.

Family and domain databases

HAMAPMF_01350. NDH1_NuoH.
InterProIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERPTHR11432. PTHR11432. 1 hit.
PfamPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEPS00667. COMPLEX1_ND1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOH_HELPH
AccessionPrimary (citable) accession number: Q1CRZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 11, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families