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Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Helicobacter pylori (strain HPAG1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit HUniRule annotation
NDH-1 subunit HUniRule annotation
Gene namesi
Name:nuoHUniRule annotation
Ordered Locus Names:HPAG1_1211
OrganismiHelicobacter pylori (strain HPAG1)
Taxonomic identifieri357544 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000008835 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei154 – 174HelicalUniRule annotationAdd BLAST21
Transmembranei188 – 208HelicalUniRule annotationAdd BLAST21
Transmembranei238 – 258HelicalUniRule annotationAdd BLAST21
Transmembranei269 – 291HelicalUniRule annotationAdd BLAST23
Transmembranei309 – 329HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002988191 – 329NADH-quinone oxidoreductase subunit HAdd BLAST329

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000228276.
KOiK00337.
OMAiLDLGWKF.
OrthoDBiPOG091H0A0A.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH. 1 hit.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1CRZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAYIIETLI KILILVAVFS ALGGFATYIE RKVLAYFQRR LGPCYVGPFG
60 70 80 90 100
LLQVAADGIK LFTKEDIIPQ GANKFIFTLA PIIAMVSAFV SMAPIPFFPN
110 120 130 140 150
FTLFGYEIKP LISDINIGFL FFLAVGAAGI YAPILAGLAS NNKYSLIGSA
160 170 180 190 200
RATIQLLSFE VVSTLTILAP LMVVGSLSLV EINHYQSGGF LDWLVFKQPL
210 220 230 240 250
AFVLFLIASY AELNRTPFDL LEHEAEIVAG YCTEYSGLKW GMFFLAEYAH
260 270 280 290 300
LFAFSFVISI VFFGGFNAWG FIPGGIAILI KAGFFVFLSM WVRATYPHVR
310 320
PDQLMNMCWK IMLPLALLNI VLTGIIILI
Length:329
Mass (Da):36,328
Last modified:July 11, 2006 - v1
Checksum:iF002A7CBF6F100F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000241 Genomic DNA. Translation: ABF85278.1.
RefSeqiWP_001277289.1. NC_008086.1.

Genome annotation databases

EnsemblBacteriaiABF85278; ABF85278; HPAG1_1211.
KEGGihpa:HPAG1_1211.
PATRICi20603875. VBIHelPyl56048_1260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000241 Genomic DNA. Translation: ABF85278.1.
RefSeqiWP_001277289.1. NC_008086.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF85278; ABF85278; HPAG1_1211.
KEGGihpa:HPAG1_1211.
PATRICi20603875. VBIHelPyl56048_1260.

Phylogenomic databases

HOGENOMiHOG000228276.
KOiK00337.
OMAiLDLGWKF.
OrthoDBiPOG091H0A0A.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH. 1 hit.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUOH_HELPH
AccessioniPrimary (citable) accession number: Q1CRZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 11, 2006
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.