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Q1CRZ4

- NUOH_HELPH

UniProt

Q1CRZ4 - NUOH_HELPH

Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Helicobacter pylori (strain HPAG1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
    2. quinone binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciHPYL357544:GH1F-1245-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit HUniRule annotation
    NDH-1 subunit HUniRule annotation
    Gene namesi
    Name:nuoHUniRule annotation
    Ordered Locus Names:HPAG1_1211
    OrganismiHelicobacter pylori (strain HPAG1)
    Taxonomic identifieri357544 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008835: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329NADH-quinone oxidoreductase subunit HPRO_0000298819Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi357544.HPAG1_1211.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalUniRule annotationAdd
    BLAST
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei75 – 9521HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei154 – 17421HelicalUniRule annotationAdd
    BLAST
    Transmembranei188 – 20821HelicalUniRule annotationAdd
    BLAST
    Transmembranei238 – 25821HelicalUniRule annotationAdd
    BLAST
    Transmembranei269 – 29123HelicalUniRule annotationAdd
    BLAST
    Transmembranei309 – 32921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1005.
    HOGENOMiHOG000228276.
    KOiK00337.
    OMAiHWYELVL.
    OrthoDBiEOG6B62B4.

    Family and domain databases

    HAMAPiMF_01350. NDH1_NuoH.
    InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view]
    PANTHERiPTHR11432. PTHR11432. 1 hit.
    PfamiPF00146. NADHdh. 1 hit.
    [Graphical view]
    PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1CRZ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAYIIETLI KILILVAVFS ALGGFATYIE RKVLAYFQRR LGPCYVGPFG    50
    LLQVAADGIK LFTKEDIIPQ GANKFIFTLA PIIAMVSAFV SMAPIPFFPN 100
    FTLFGYEIKP LISDINIGFL FFLAVGAAGI YAPILAGLAS NNKYSLIGSA 150
    RATIQLLSFE VVSTLTILAP LMVVGSLSLV EINHYQSGGF LDWLVFKQPL 200
    AFVLFLIASY AELNRTPFDL LEHEAEIVAG YCTEYSGLKW GMFFLAEYAH 250
    LFAFSFVISI VFFGGFNAWG FIPGGIAILI KAGFFVFLSM WVRATYPHVR 300
    PDQLMNMCWK IMLPLALLNI VLTGIIILI 329
    Length:329
    Mass (Da):36,328
    Last modified:July 11, 2006 - v1
    Checksum:iF002A7CBF6F100F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000241 Genomic DNA. Translation: ABF85278.1.
    RefSeqiYP_627952.1. NC_008086.1.

    Genome annotation databases

    EnsemblBacteriaiABF85278; ABF85278; HPAG1_1211.
    GeneIDi4098294.
    KEGGihpa:HPAG1_1211.
    PATRICi20603875. VBIHelPyl56048_1260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000241 Genomic DNA. Translation: ABF85278.1 .
    RefSeqi YP_627952.1. NC_008086.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357544.HPAG1_1211.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF85278 ; ABF85278 ; HPAG1_1211 .
    GeneIDi 4098294.
    KEGGi hpa:HPAG1_1211.
    PATRICi 20603875. VBIHelPyl56048_1260.

    Phylogenomic databases

    eggNOGi COG1005.
    HOGENOMi HOG000228276.
    KOi K00337.
    OMAi HWYELVL.
    OrthoDBi EOG6B62B4.

    Enzyme and pathway databases

    BioCyci HPYL357544:GH1F-1245-MONOMER.

    Family and domain databases

    HAMAPi MF_01350. NDH1_NuoH.
    InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view ]
    PANTHERi PTHR11432. PTHR11432. 1 hit.
    Pfami PF00146. NADHdh. 1 hit.
    [Graphical view ]
    PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression."
      Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.
      Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HPAG1.

    Entry informationi

    Entry nameiNUOH_HELPH
    AccessioniPrimary (citable) accession number: Q1CRZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3