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Q1CRQ1 (PSD_HELPH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:HPAG1_1304
OrganismHelicobacter pylori (strain HPAG1) [Complete proteome] [HAMAP]
Taxonomic identifier357544 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00662

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00662

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00662

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000262121
Chain236 – 26732Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000262122

Sites

Site235 – 2362Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2361Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1CRQ1 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: A996C08B9333CABA

FASTA26730,144
        10         20         30         40         50         60 
MVALSNALSR VFGSLAGYEF PSFIQKGINA LYVKIFKIDL SEFEPLENYK SLNALFTRSL 

        70         80         90        100        110        120 
KKERPFDKAP NICIAPCDAL ITECAFLDND SALQIKGMPY KAHELVGEIN PLNPSFFYAN 

       130        140        150        160        170        180 
FYLSPKDYHH YHAPCDLEIL EARYFAGKLL PVNKPSLHKN NNLFVGNERV TLVAKDVQGN 

       190        200        210        220        230        240 
RLYFVAVGAL NVGKMRFNFD KNIQTNAKAR FTQTYSYNPP IKVKKGDNLG NFEMGSTIVL 

       250        260 
FIQNTAFKDL KEKSVKFGES IGEFHAN

« Hide

References

[1]"The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression."
Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed: 16788065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HPAG1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000241 Genomic DNA. Translation: ABF85371.1.
RefSeqYP_628045.1. NC_008086.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ1CRQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4098452.
GenomeReviewsGene locus HPAG1_1304 in contig CP000241_GR.
KEGGhpa:HPAG1_1304.
PATRIC20604055. VBIHelPyl56048_1350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0688.
HOGENOMHBG302256.
OMASMATVWH.
ProtClustDBPRK03934.

Enzyme and pathway databases

BioCycHPYL357544:HPAG1_1304-MONOMER.

Family and domain databases

HAMAPMF_00662. PS_decarb_type1.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
KOK01613.
PANTHERPTHR10067. PS_decarb. 1 hit.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00163. PS_decarb. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_HELPH
AccessionPrimary (citable) accession number: Q1CRQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 11, 2006
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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