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Q1CR25

- PDXJ_HELPH

UniProt

Q1CR25 - PDXJ_HELPH

Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Helicobacter pylori (strain HPAG1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

    Catalytic activityi

    1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei6 – 613-amino-2-oxopropyl phosphateUniRule annotation
    Binding sitei17 – 1713-amino-2-oxopropyl phosphateUniRule annotation
    Active sitei43 – 431Proton acceptorUniRule annotation
    Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
    Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Active sitei70 – 701Proton acceptorUniRule annotation
    Binding sitei102 – 10211-deoxy-D-xylulose 5-phosphateUniRule annotation
    Sitei151 – 1511Transition state stabilizerUniRule annotation
    Active sitei215 – 2151Proton donorUniRule annotation
    Binding sitei216 – 21613-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Enzyme and pathway databases

    BioCyciHPYL357544:GH1F-1568-MONOMER.
    UniPathwayiUPA00244; UER00313.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
    Short name:
    PNP synthaseUniRule annotation
    Gene namesi
    Name:pdxJUniRule annotation
    Ordered Locus Names:HPAG1_1530
    OrganismiHelicobacter pylori (strain HPAG1)
    Taxonomic identifieri357544 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008835: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Pyridoxine 5'-phosphate synthasePRO_1000022375Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi357544.HPAG1_1530.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1CR25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni8 – 921-deoxy-D-xylulose 5-phosphate bindingUniRule annotation
    Regioni237 – 23823-amino-2-oxopropyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0854.
    HOGENOMiHOG000258094.
    KOiK03474.
    OMAiHAVCIVP.
    OrthoDBiEOG6M9F0H.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00279. PdxJ.
    InterProiIPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view]
    PfamiPF03740. PdxJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF63892. SSF63892. 1 hit.
    TIGRFAMsiTIGR00559. pdxJ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1CR25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFGLNIDHI VTLREIRKTY EPEILEALFI AKNTHKVDLI TIHLREDKRH    50
    IQNEDVLRLL EISPLPINIE CSINVAITDF LCSLKNKPSK VTIVPENRNE 100
    VTTEGGLDCS LKGLGEVIRA YHNKGIEVSL FVDPLKDALH FAKEHQVKQV 150
    EFHTGVYANL HNALYSNANN QIHAISALKD KCPKELKEEL HNAFLQLRRM 200
    SKEAFFMGIV VCAGHGLNYT NVKELLKIPS LRELNIGHSV VSKAVLVGLE 250
    KAILEMAQLI KR 262
    Length:262
    Mass (Da):29,663
    Last modified:July 11, 2006 - v1
    Checksum:iCFC43A73505EC354
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000241 Genomic DNA. Translation: ABF85597.1.
    RefSeqiWP_001210844.1. NC_008086.1.
    YP_628271.1. NC_008086.1.

    Genome annotation databases

    EnsemblBacteriaiABF85597; ABF85597; HPAG1_1530.
    GeneIDi4098402.
    KEGGihpa:HPAG1_1530.
    PATRICi20604533. VBIHelPyl56048_1585.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000241 Genomic DNA. Translation: ABF85597.1 .
    RefSeqi WP_001210844.1. NC_008086.1.
    YP_628271.1. NC_008086.1.

    3D structure databases

    ProteinModelPortali Q1CR25.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357544.HPAG1_1530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF85597 ; ABF85597 ; HPAG1_1530 .
    GeneIDi 4098402.
    KEGGi hpa:HPAG1_1530.
    PATRICi 20604533. VBIHelPyl56048_1585.

    Phylogenomic databases

    eggNOGi COG0854.
    HOGENOMi HOG000258094.
    KOi K03474.
    OMAi HAVCIVP.
    OrthoDBi EOG6M9F0H.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00313 .
    BioCyci HPYL357544:GH1F-1568-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00279. PdxJ.
    InterProi IPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view ]
    Pfami PF03740. PdxJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63892. SSF63892. 1 hit.
    TIGRFAMsi TIGR00559. pdxJ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression."
      Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A., Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G., Gordon J.I.
      Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HPAG1.

    Entry informationi

    Entry nameiPDXJ_HELPH
    AccessioniPrimary (citable) accession number: Q1CR25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3