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Protein
Submitted name:

Bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/DNA-binding transcriptional repressor, bio-5'-AMP-binding

Gene

birA

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. biotin-[acetyl-CoA-carboxylase] ligase activity Source: UniProtKB-EC
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular protein modification process Source: InterPro
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseImported

Keywords - Ligandi

DNA-bindingImported

Enzyme and pathway databases

BioCyciYPES377628:GIXK-228-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/DNA-binding transcriptional repressor, bio-5'-AMP-bindingImported (EC:6.3.4.15Imported)
Submitted name:
Bifunctional protein BirAImported (EC:6.3.4.15Imported)
Gene namesi
Name:birAImported
Ordered Locus Names:YPN_0206Imported
ORF Names:YP516_0181Imported
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)Imported
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000008936: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi377628.YPN_0206.

Structurei

3D structure databases

ProteinModelPortaliQ1CN91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains BPL/LPL catalytic domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0340.
HOGENOMiHOG000041812.
KOiK03524.
OMAiIYSADIE.
OrthoDBiEOG6DNTBX.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR004408. Biotin_CoA_COase_ligase.
IPR004409. Biotin_operon_repress_HTH.
IPR003142. BPL_C.
IPR004143. BPL_LipA_LipB.
IPR013196. HTH_11.
IPR008988. Transcriptional_repressor_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF08279. HTH_11. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
TIGR00122. birA_repr_reg. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CN91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIRVPLRL VSILSDGFFH SGEQLGETLG MSRAAINKHM QTIRDWGLDV
60 70 80 90 100
FTVPGKGYSL PTSIQLLDEQ KILSYLPTGH VTVLPVVDST NQYLLDRITE
110 120 130 140 150
LKSGDACVAE YQQAGRGRRG RQWVSPFGAN LYLSMYWRLE QGPAAAMGLS
160 170 180 190 200
LVVGIVMAEV LQNLGAEKVR VKWPNDLYLN DKKLAGILVE LTGKTGDAAQ
210 220 230 240 250
LVIGAGINLT MRGSETNAIN QDWINLQDAG VTIDRNKLTA EILSELRLAV
260 270 280 290 300
VKFENEGLSA FLSRWQKMDN YLNRPVKLII GNQEIFGIAR GIDQQGALLL
310
EQDGNIKPYI GGEISLRGV
Length:319
Mass (Da):35,165
Last modified:July 11, 2006 - v1
Checksum:iB58E9306939E3B2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG16539.1.
ACNQ01000003 Genomic DNA. Translation: EEO78492.1.
RefSeqiYP_646139.1. NC_008149.1.

Genome annotation databases

EnsemblBacteriaiABG16539; ABG16539; YPN_0206.
EEO78492; EEO78492; YP516_0181.
GeneIDi4126530.
KEGGiypn:YPN_0206.
PATRICi18599349. VBIYerPes46733_0368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG16539.1.
ACNQ01000003 Genomic DNA. Translation: EEO78492.1.
RefSeqiYP_646139.1. NC_008149.1.

3D structure databases

ProteinModelPortaliQ1CN91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi377628.YPN_0206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG16539; ABG16539; YPN_0206.
EEO78492; EEO78492; YP516_0181.
GeneIDi4126530.
KEGGiypn:YPN_0206.
PATRICi18599349. VBIYerPes46733_0368.

Phylogenomic databases

eggNOGiCOG0340.
HOGENOMiHOG000041812.
KOiK03524.
OMAiIYSADIE.
OrthoDBiEOG6DNTBX.

Enzyme and pathway databases

BioCyciYPES377628:GIXK-228-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR004408. Biotin_CoA_COase_ligase.
IPR004409. Biotin_operon_repress_HTH.
IPR003142. BPL_C.
IPR004143. BPL_LipA_LipB.
IPR013196. HTH_11.
IPR008988. Transcriptional_repressor_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF08279. HTH_11. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
TIGR00122. birA_repr_reg. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Nepal516Imported.
  3. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516Imported.

Entry informationi

Entry nameiQ1CN91_YERPN
AccessioniPrimary (citable) accession number: Q1CN91
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: January 7, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.