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Protein

Altronate oxidoreductase

Gene

uxaB

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 2912NADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. tagaturonate reductase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciYPES377628:GIXK-481-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Altronate oxidoreductaseUniRule annotation (EC:1.1.1.58UniRule annotation)
Alternative name(s):
Tagaturonate dehydrogenaseUniRule annotation
Tagaturonate reductaseUniRule annotation
Gene namesi
Name:uxaBUniRule annotation
Ordered Locus Names:YPN_0449
ORF Names:YP516_0464
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000008936 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Altronate oxidoreductasePRO_1000044710Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi377628.YPN_0449.

Structurei

3D structure databases

ProteinModelPortaliQ1CMJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family. UxaB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000029586.
KOiK00041.
OMAiHNTFCST.
OrthoDBiEOG6CVVB8.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR023668. Altronate_OxRdtase.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CMJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLNRRDFP GRSHPDKIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV
60 70 80 90 100
IRPIDTDFPP SLSTQDGLYT AVIRGLNEQG EAVRESRLIR SVNREINIYR
110 120 130 140 150
QFDDYLALAR DANIRFMFSN TTEAGIAWNE ADQFSDAPPS SFPAKLTRLL
160 170 180 190 200
FERFEHFDGA ADKGWVLLPC ELIDYNGEAL RELVLRYASH WQLPAAFTHW
210 220 230 240 250
LTENNTFCST LVDRIVTGYP RDEVAALQTE LGYQDSFLDT AEYFYLFVIQ
260 270 280 290 300
GPQGLAQELR LDQLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAYLSG
310 320 330 340 350
LDTVGQTMDD AQISRFVEKT ITEEIVPVLD LPEDELLSFS QAVLSRFRNP
360 370 380 390 400
FIQHQLLSIA LNGMTKFRTR ILPQLLTYQQ QKGQLPPRLT FALAALIAFY
410 420 430 440 450
RGEREGQTYP LQDDAHWLER YSTLWNGVKH GDIALAELVN RVLSDANHWG
460 470 480
QDLTAVPQLA NQVTEQLQTI LSRGMRAAVA AYS
Length:483
Mass (Da):54,907
Last modified:July 11, 2006 - v1
Checksum:iBDDB13837F6564B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG16781.1.
ACNQ01000006 Genomic DNA. Translation: EEO78237.1.
RefSeqiYP_646381.1. NC_008149.1.

Genome annotation databases

EnsemblBacteriaiABG16781; ABG16781; YPN_0449.
EEO78237; EEO78237; YP516_0464.
GeneIDi4125790.
KEGGiypn:YPN_0449.
PATRICi18599913. VBIYerPes46733_0642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG16781.1.
ACNQ01000006 Genomic DNA. Translation: EEO78237.1.
RefSeqiYP_646381.1. NC_008149.1.

3D structure databases

ProteinModelPortaliQ1CMJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi377628.YPN_0449.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG16781; ABG16781; YPN_0449.
EEO78237; EEO78237; YP516_0464.
GeneIDi4125790.
KEGGiypn:YPN_0449.
PATRICi18599913. VBIYerPes46733_0642.

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000029586.
KOiK00041.
OMAiHNTFCST.
OrthoDBiEOG6CVVB8.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciYPES377628:GIXK-481-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00670. Altron_oxidoreduct.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR023668. Altronate_OxRdtase.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516.
  2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUXAB_YERPN
AccessioniPrimary (citable) accession number: Q1CMJ9
Secondary accession number(s): C4GP05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: April 29, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.