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Q1CMJ9

- UXAB_YERPN

UniProt

Q1CMJ9 - UXAB_YERPN

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Protein
Altronate oxidoreductase
Gene
uxaB, YPN_0449, YP516_0464
Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-altronate + NAD+ = D-tagaturonate + NADH.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 2912NAD By similarity
Add
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. tagaturonate reductase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciYPES377628:GIXK-481-MONOMER.
    UniPathwayiUPA00246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Altronate oxidoreductase (EC:1.1.1.58)
    Alternative name(s):
    Tagaturonate dehydrogenase
    Tagaturonate reductase
    Gene namesi
    Name:uxaB
    Ordered Locus Names:YPN_0449
    ORF Names:YP516_0464
    OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
    Taxonomic identifieri377628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000008936: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Altronate oxidoreductaseUniRule annotation
    PRO_1000044710Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi377628.YPN_0449.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1CMJ9.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000029586.
    KOiK00041.
    OMAiHNTFCST.
    OrthoDBiEOG6CVVB8.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00670. Altron_oxidoreduct.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1CMJ9-1 [UniParc]FASTAAdd to Basket

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    MQTLNRRDFP GRSHPDKIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV    50
    IRPIDTDFPP SLSTQDGLYT AVIRGLNEQG EAVRESRLIR SVNREINIYR 100
    QFDDYLALAR DANIRFMFSN TTEAGIAWNE ADQFSDAPPS SFPAKLTRLL 150
    FERFEHFDGA ADKGWVLLPC ELIDYNGEAL RELVLRYASH WQLPAAFTHW 200
    LTENNTFCST LVDRIVTGYP RDEVAALQTE LGYQDSFLDT AEYFYLFVIQ 250
    GPQGLAQELR LDQLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAYLSG 300
    LDTVGQTMDD AQISRFVEKT ITEEIVPVLD LPEDELLSFS QAVLSRFRNP 350
    FIQHQLLSIA LNGMTKFRTR ILPQLLTYQQ QKGQLPPRLT FALAALIAFY 400
    RGEREGQTYP LQDDAHWLER YSTLWNGVKH GDIALAELVN RVLSDANHWG 450
    QDLTAVPQLA NQVTEQLQTI LSRGMRAAVA AYS 483
    Length:483
    Mass (Da):54,907
    Last modified:July 11, 2006 - v1
    Checksum:iBDDB13837F6564B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG16781.1.
    ACNQ01000006 Genomic DNA. Translation: EEO78237.1.
    RefSeqiYP_646381.1. NC_008149.1.

    Genome annotation databases

    EnsemblBacteriaiABG16781; ABG16781; YPN_0449.
    EEO78237; EEO78237; YP516_0464.
    GeneIDi4125790.
    KEGGiypn:YPN_0449.
    PATRICi18599913. VBIYerPes46733_0642.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG16781.1 .
    ACNQ01000006 Genomic DNA. Translation: EEO78237.1 .
    RefSeqi YP_646381.1. NC_008149.1.

    3D structure databases

    ProteinModelPortali Q1CMJ9.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 377628.YPN_0449.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG16781 ; ABG16781 ; YPN_0449 .
    EEO78237 ; EEO78237 ; YP516_0464 .
    GeneIDi 4125790.
    KEGGi ypn:YPN_0449.
    PATRICi 18599913. VBIYerPes46733_0642.

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000029586.
    KOi K00041.
    OMAi HNTFCST.
    OrthoDBi EOG6CVVB8.

    Enzyme and pathway databases

    UniPathwayi UPA00246 .
    BioCyci YPES377628:GIXK-481-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00670. Altron_oxidoreduct.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR023668. Altronate_OxRdtase.
    IPR013328. DH_multihelical.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
      Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
      J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516.
    2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
      Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUXAB_YERPN
    AccessioniPrimary (citable) accession number: Q1CMJ9
    Secondary accession number(s): C4GP05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 11, 2006
    Last modified: May 14, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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