Q1CMD9 (UPPP_YERPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	YPN_0509
ORF Names:	YP516_0528

Organism

Yersinia pestis bv. Antiqua (strain Nepal516) [Complete proteome] [HAMAP]

Taxonomic identifier

377628 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pestis

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000290782
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	153 – 172	20	Helical; Potential
	Transmembrane	189 – 209	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1CMD9 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 164FC644788F2189	FASTA	272	29,483
	10 20 30 40 50 60 MTDMYSLFVA FILGVVEGLT EFLPVSSTGH MIIVGELLGF TGDKAKTFEV IIQLGSILAV 70 80 90 100 110 120 VVVFWRRLFG LIGIHFGAVP HEGKTNGHLT LGHILLAMIP AVILGLAFHD VIKALFDPKS 130 140 150 160 170 180 VMYALVAGGV LLLAAEWLKP KNPKAVGLDD ITYRQAFAIG CFQCLALWPG FSRSGATISG 190 200 210 220 230 240 GMLVGVNRYA ASEFSFILAV PMMIGASGLD LYKSLHFLTL GDLPMFAVGF ITAFIVALIA 250 260 270 IKTFLSLIKR ISFVPFAIYR FIVAAVVYWV FM

References

[1]	"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen." Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L. J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nepal516.
[2]	"Yersinia pestis Nepal516A whole genome shotgun sequencing project." Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000305 Genomic DNA. Translation: ABG16841.1. ACNQ01000006 Genomic DNA. Translation: EEO78299.1.
RefSeq	YP_646441.1. NC_008149.1.
3D structure databases
ProteinModelPortal	Q1CMD9.
ModBase	Search...
Protein-protein interaction databases
STRING	377628.YPN_0509.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG16841; ABG16841; YPN_0509. EEO78299; EEO78299; YP516_0528.
GeneID	4124626.
KEGG	ypn:YPN_0509.
PATRIC	18600045. VBIYerPes46733_0707.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_YERPN

Accession

Primary (citable) accession number: Q1CMD9
Secondary accession number(s): C4GP67

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program