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Q1CM01

- AMPA_YERPN

UniProt

Q1CM01 - AMPA_YERPN

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi270 – 2701Manganese 2UniRule annotation
    Metal bindingi275 – 2751Manganese 1UniRule annotation
    Metal bindingi275 – 2751Manganese 2UniRule annotation
    Active sitei282 – 2821UniRule annotation
    Metal bindingi293 – 2931Manganese 2UniRule annotation
    Metal bindingi352 – 3521Manganese 1UniRule annotation
    Metal bindingi354 – 3541Manganese 1UniRule annotation
    Metal bindingi354 – 3541Manganese 2UniRule annotation
    Active sitei356 – 3561UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciYPES377628:GIXK-682-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation (EC:3.4.11.1UniRule annotation)
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation (EC:3.4.11.10UniRule annotation)
    Short name:
    LAPUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotation
    Ordered Locus Names:YPN_0647
    ORF Names:YP516_0683
    OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
    Taxonomic identifieri377628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000008936: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Probable cytosol aminopeptidasePRO_1000020005Add
    BLAST

    Proteomic databases

    PRIDEiQ1CM01.

    Interactioni

    Protein-protein interaction databases

    STRINGi377628.YPN_0647.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1CM01.
    SMRiQ1CM01. Positions 1-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243132.
    KOiK01255.
    OMAiANEAKMS.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1CM01-1 [UniParc]FASTAAdd to Basket

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    MEFSVKSGSP EKQRSACIVV GVFEPRRLSP IAEQLDKISD GYISALLRRG    50
    ELEGKVGQTL LLHHVPNILS ERILLIGCGK ERELDERQYK QVIQKTINTL 100
    NDTGSMEAVC FLTELHVKGR NTYWKVRQAV ETAKETLYTF DQLKSNKTEP 150
    RRPLRKMVFN VPTRRELTSG ERAIQHGLAI ASGIKAAKDL GNMPPNICNA 200
    AYLASQARQL ADAFSTNTVT RVIGEQQMKE LGMHAYLAVG HGSQNESLMS 250
    VIEYKGNPNK DAKPIVLVGK GLTFDSGGIS IKPAEGMDEM KYDMCGAATV 300
    YGVMRVVAEL QLPLNVVGVL AGCENMPGGR AYRPGDILTT MSGQTVEVLN 350
    TDAEGRLVLC DALTYVERFE PELVIDIATL TGACVVALGN HLTGLMSNHN 400
    PLAHELIGAS EQAGDRAWRL PLGEEYYEQL DSNFADMANI GGRAGGAITA 450
    GCFLSRFTRK YSWAHLDIAG TAWRSGKNKG ATGRPVALLS QFLLNRAGLN 500
    GDD 503
    Length:503
    Mass (Da):54,797
    Last modified:July 11, 2006 - v1
    Checksum:iE3A27876304218F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG16979.1.
    ACNQ01000006 Genomic DNA. Translation: EEO78446.1.
    RefSeqiYP_646579.1. NC_008149.1.

    Genome annotation databases

    EnsemblBacteriaiABG16979; ABG16979; YPN_0647.
    EEO78446; EEO78446; YP516_0683.
    GeneIDi4125286.
    KEGGiypn:YPN_0647.
    PATRICi18600353. VBIYerPes46733_0861.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG16979.1 .
    ACNQ01000006 Genomic DNA. Translation: EEO78446.1 .
    RefSeqi YP_646579.1. NC_008149.1.

    3D structure databases

    ProteinModelPortali Q1CM01.
    SMRi Q1CM01. Positions 1-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 377628.YPN_0647.

    Proteomic databases

    PRIDEi Q1CM01.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG16979 ; ABG16979 ; YPN_0647 .
    EEO78446 ; EEO78446 ; YP516_0683 .
    GeneIDi 4125286.
    KEGGi ypn:YPN_0647.
    PATRICi 18600353. VBIYerPes46733_0861.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243132.
    KOi K01255.
    OMAi ANEAKMS.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci YPES377628:GIXK-682-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
      Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
      J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516.
    2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
      Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiAMPA_YERPN
    AccessioniPrimary (citable) accession number: Q1CM01
    Secondary accession number(s): C4GPL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3