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Q1CM01

- AMPA_YERPN

UniProt

Q1CM01 - AMPA_YERPN

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Protein
Probable cytosol aminopeptidase
Gene
pepA, YPN_0647, YP516_0683
Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi270 – 2701Manganese 2 By similarity
Metal bindingi275 – 2751Manganese 1 By similarity
Metal bindingi275 – 2751Manganese 2 By similarity
Active sitei282 – 2821 Reviewed prediction
Metal bindingi293 – 2931Manganese 2 By similarity
Metal bindingi352 – 3521Manganese 1 By similarity
Metal bindingi354 – 3541Manganese 1 By similarity
Metal bindingi354 – 3541Manganese 2 By similarity
Active sitei356 – 3561 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYPES377628:GIXK-682-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytosol aminopeptidase (EC:3.4.11.1)
Alternative name(s):
Leucine aminopeptidase (EC:3.4.11.10)
Short name:
LAP
Leucyl aminopeptidase
Gene namesi
Name:pepA
Ordered Locus Names:YPN_0647
ORF Names:YP516_0683
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000008936: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Probable cytosol aminopeptidaseUniRule annotation
PRO_1000020005Add
BLAST

Proteomic databases

PRIDEiQ1CM01.

Interactioni

Protein-protein interaction databases

STRINGi377628.YPN_0647.

Structurei

3D structure databases

ProteinModelPortaliQ1CM01.
SMRiQ1CM01. Positions 1-503.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M17 family.

Phylogenomic databases

eggNOGiCOG0260.
HOGENOMiHOG000243132.
KOiK01255.
OMAiANEAKMS.
OrthoDBiEOG6FV8B3.

Family and domain databases

HAMAPiMF_00181. Cytosol_peptidase_M17.
InterProiIPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view]
PfamiPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSiPR00481. LAMNOPPTDASE.
PROSITEiPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1CM01-1 [UniParc]FASTAAdd to Basket

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MEFSVKSGSP EKQRSACIVV GVFEPRRLSP IAEQLDKISD GYISALLRRG    50
ELEGKVGQTL LLHHVPNILS ERILLIGCGK ERELDERQYK QVIQKTINTL 100
NDTGSMEAVC FLTELHVKGR NTYWKVRQAV ETAKETLYTF DQLKSNKTEP 150
RRPLRKMVFN VPTRRELTSG ERAIQHGLAI ASGIKAAKDL GNMPPNICNA 200
AYLASQARQL ADAFSTNTVT RVIGEQQMKE LGMHAYLAVG HGSQNESLMS 250
VIEYKGNPNK DAKPIVLVGK GLTFDSGGIS IKPAEGMDEM KYDMCGAATV 300
YGVMRVVAEL QLPLNVVGVL AGCENMPGGR AYRPGDILTT MSGQTVEVLN 350
TDAEGRLVLC DALTYVERFE PELVIDIATL TGACVVALGN HLTGLMSNHN 400
PLAHELIGAS EQAGDRAWRL PLGEEYYEQL DSNFADMANI GGRAGGAITA 450
GCFLSRFTRK YSWAHLDIAG TAWRSGKNKG ATGRPVALLS QFLLNRAGLN 500
GDD 503
Length:503
Mass (Da):54,797
Last modified:July 11, 2006 - v1
Checksum:iE3A27876304218F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000305 Genomic DNA. Translation: ABG16979.1.
ACNQ01000006 Genomic DNA. Translation: EEO78446.1.
RefSeqiYP_646579.1. NC_008149.1.

Genome annotation databases

EnsemblBacteriaiABG16979; ABG16979; YPN_0647.
EEO78446; EEO78446; YP516_0683.
GeneIDi4125286.
KEGGiypn:YPN_0647.
PATRICi18600353. VBIYerPes46733_0861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000305 Genomic DNA. Translation: ABG16979.1 .
ACNQ01000006 Genomic DNA. Translation: EEO78446.1 .
RefSeqi YP_646579.1. NC_008149.1.

3D structure databases

ProteinModelPortali Q1CM01.
SMRi Q1CM01. Positions 1-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 377628.YPN_0647.

Proteomic databases

PRIDEi Q1CM01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG16979 ; ABG16979 ; YPN_0647 .
EEO78446 ; EEO78446 ; YP516_0683 .
GeneIDi 4125286.
KEGGi ypn:YPN_0647.
PATRICi 18600353. VBIYerPes46733_0861.

Phylogenomic databases

eggNOGi COG0260.
HOGENOMi HOG000243132.
KOi K01255.
OMAi ANEAKMS.
OrthoDBi EOG6FV8B3.

Enzyme and pathway databases

BioCyci YPES377628:GIXK-682-MONOMER.

Family and domain databases

HAMAPi MF_00181. Cytosol_peptidase_M17.
InterProi IPR011356. Leucine_aapep/pepB.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_leu_NH2_pept.
IPR008283. Peptidase_M17_N.
[Graphical view ]
Pfami PF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view ]
PRINTSi PR00481. LAMNOPPTDASE.
PROSITEi PS00631. CYTOSOL_AP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516.
  2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAMPA_YERPN
AccessioniPrimary (citable) accession number: Q1CM01
Secondary accession number(s): C4GPL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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