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Q1CIA7 (Q1CIA7_YERPN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase HAMAP-Rule MF_01201

EC=5.1.1.1 HAMAP-Rule MF_01201
Gene names
Ordered Locus Names:YPN_1944 EMBL ABG18273.1
ORF Names:YP516_2164 EMBL EEO76570.1
OrganismYersinia pestis bv. Antiqua (strain Nepal516) [Complete proteome] [HAMAP] EMBL ABG18273.1
Taxonomic identifier377628 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. SAAS SAAS020622 HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS020622 HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential EMBL ABG18273.1
Chain27 – 409383 Potential EMBL ABG18273.1
PRO_5000115363

Sites

Active site761Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site3011Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1751Substrate By similarity HAMAP-Rule MF_01201
Binding site3491Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue761N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
Q1CIA7 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: BBFCC8C5A2E4241C

FASTA40944,770
        10         20         30         40         50         60 
MHVRFRHLFL LPLITLVACS QPVSKNHLSL TSLSANAQQP VVNNAWLEIS QGALDFNTKK 

        70         80         90        100        110        120 
MLTLLDNKST LCAILKGDAY GHDLTLVTPV MLKNNVQCIG VASNQELKTV RDLGFTGQLI 

       130        140        150        160        170        180 
RVRSATLKEM QQAMAYDVEE LIGDKTVAEQ LNNIAKLNGK VLRIHLALNS AGMSRNGLEV 

       190        200        210        220        230        240 
SKARGLNDAK TIAGLKNLTI VGIMSHYPVE DASEIKADLA RFQQQAKDVI AVTGLKREKI 

       250        260        270        280        290        300 
KLHVANTFAT LAVPDSWLDM VRVGGVFYGD TIASTEYKRV MTFKSNIASL NNYPKGGTVG 

       310        320        330        340        350        360 
YDRTYTLKRD SLLANIPVGY ADGYRRVFSN AGHVIIQGQR LPVLGKTSMN TVIVDVTDLK 

       370        380        390        400 
KVSLGDEVVL FGKQGNAEIQ AEEIEDLSGA LFTEMSILWG ATNKRILVD 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
Chain P.S., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nepal516 EMBL ABG18273.1.
[2]"Complete sequence of chromosome of Yersinia pestis Nepal516."
US DOE Joint Genome Institute
Barry K., Lucas S., Lapidus A., Copeland A., Detter J.C., Glavina del Rio T., Hammon N., Dalin E., Tice H., Pitluck S., Chain P., Hu P., Malfatti S.A., Radnedge L., Vergez L.M., Larimer F., Land M., Hauser L. expand/collapse author list , Worsham P., Chu M.C., Andersen G., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Nepal516 EMBL ABG18273.1.
[3]"Yersinia pestis Nepal516A whole genome shotgun sequencing project."
Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nepal516.
[4]"Yersinia pestis Nepal516A whole genome shotgun sequencing project."
Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nepal516 EMBL EEO76570.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000305 Genomic DNA. Translation: ABG18273.1.
ACNQ01000011 Genomic DNA. Translation: EEO76570.1.
RefSeqYP_647873.1. NC_008149.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING377628.YPN_1944.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG18273; ABG18273; YPN_1944.
EEO76570; EEO76570; YP516_2164.
GeneID4122717.
KEGGypn:YPN_1944.
PATRIC18603372. VBIYerPes46733_2346.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000279190.
KOK01775.
OMAQQIPCVA.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycYPES377628:GIXK-2005-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1CIA7_YERPN
AccessionPrimary (citable) accession number: Q1CIA7
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)