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Q1CIA7

- Q1CIA7_YERPN

UniProt

Q1CIA7 - Q1CIA7_YERPN

Protein

Alanine racemase

Gene

YPN_1944

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei175 – 1751SubstrateUniRule annotation
    Active sitei301 – 3011Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei349 – 3491Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciYPES377628:GIXK-2005-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:YPN_1944Imported
    ORF Names:YP516_2164Imported
    OrganismiYersinia pestis bv. Antiqua (strain Nepal516)Imported
    Taxonomic identifieri377628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000008936: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626 PotentialImportedAdd
    BLAST
    Chaini27 – 409383 PotentialImportedPRO_5000115363Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei76 – 761N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi377628.YPN_1944.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000279190.
    KOiK01775.
    OMAiQQIPCVA.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1CIA7-1 [UniParc]FASTAAdd to Basket

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    MHVRFRHLFL LPLITLVACS QPVSKNHLSL TSLSANAQQP VVNNAWLEIS    50
    QGALDFNTKK MLTLLDNKST LCAILKGDAY GHDLTLVTPV MLKNNVQCIG 100
    VASNQELKTV RDLGFTGQLI RVRSATLKEM QQAMAYDVEE LIGDKTVAEQ 150
    LNNIAKLNGK VLRIHLALNS AGMSRNGLEV SKARGLNDAK TIAGLKNLTI 200
    VGIMSHYPVE DASEIKADLA RFQQQAKDVI AVTGLKREKI KLHVANTFAT 250
    LAVPDSWLDM VRVGGVFYGD TIASTEYKRV MTFKSNIASL NNYPKGGTVG 300
    YDRTYTLKRD SLLANIPVGY ADGYRRVFSN AGHVIIQGQR LPVLGKTSMN 350
    TVIVDVTDLK KVSLGDEVVL FGKQGNAEIQ AEEIEDLSGA LFTEMSILWG 400
    ATNKRILVD 409
    Length:409
    Mass (Da):44,770
    Last modified:July 11, 2006 - v1
    Checksum:iBBFCC8C5A2E4241C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG18273.1.
    ACNQ01000011 Genomic DNA. Translation: EEO76570.1.
    RefSeqiYP_647873.1. NC_008149.1.

    Genome annotation databases

    EnsemblBacteriaiABG18273; ABG18273; YPN_1944.
    EEO76570; EEO76570; YP516_2164.
    GeneIDi4122717.
    KEGGiypn:YPN_1944.
    PATRICi18603372. VBIYerPes46733_2346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG18273.1 .
    ACNQ01000011 Genomic DNA. Translation: EEO76570.1 .
    RefSeqi YP_647873.1. NC_008149.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 377628.YPN_1944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG18273 ; ABG18273 ; YPN_1944 .
    EEO76570 ; EEO76570 ; YP516_2164 .
    GeneIDi 4122717.
    KEGGi ypn:YPN_1944.
    PATRICi 18603372. VBIYerPes46733_2346.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000279190.
    KOi K01775.
    OMAi QQIPCVA.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci YPES377628:GIXK-2005-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
      Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
      J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Nepal516Imported.
    3. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
      Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516Imported.

    Entry informationi

    Entry nameiQ1CIA7_YERPN
    AccessioniPrimary (citable) accession number: Q1CIA7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3