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Q1CIA7

- Q1CIA7_YERPN

UniProt

Q1CIA7 - Q1CIA7_YERPN

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Protein

Alanine racemase

Gene
YPN_1944, YP516_2164
Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei175 – 1751Substrate By similarityUniRule annotation
Active sitei301 – 3011Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei349 – 3491Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciYPES377628:GIXK-2005-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:YPN_1944Imported
ORF Names:YP516_2164Imported
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)Imported
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000008936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 PredictedImportedAdd
BLAST
Chaini27 – 409383 PredictedImportedPRO_5000115363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi377628.YPN_1944.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000279190.
KOiK01775.
OMAiQQIPCVA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1CIA7-1 [UniParc]FASTAAdd to Basket

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MHVRFRHLFL LPLITLVACS QPVSKNHLSL TSLSANAQQP VVNNAWLEIS    50
QGALDFNTKK MLTLLDNKST LCAILKGDAY GHDLTLVTPV MLKNNVQCIG 100
VASNQELKTV RDLGFTGQLI RVRSATLKEM QQAMAYDVEE LIGDKTVAEQ 150
LNNIAKLNGK VLRIHLALNS AGMSRNGLEV SKARGLNDAK TIAGLKNLTI 200
VGIMSHYPVE DASEIKADLA RFQQQAKDVI AVTGLKREKI KLHVANTFAT 250
LAVPDSWLDM VRVGGVFYGD TIASTEYKRV MTFKSNIASL NNYPKGGTVG 300
YDRTYTLKRD SLLANIPVGY ADGYRRVFSN AGHVIIQGQR LPVLGKTSMN 350
TVIVDVTDLK KVSLGDEVVL FGKQGNAEIQ AEEIEDLSGA LFTEMSILWG 400
ATNKRILVD 409
Length:409
Mass (Da):44,770
Last modified:July 11, 2006 - v1
Checksum:iBBFCC8C5A2E4241C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000305 Genomic DNA. Translation: ABG18273.1.
ACNQ01000011 Genomic DNA. Translation: EEO76570.1.
RefSeqiYP_647873.1. NC_008149.1.

Genome annotation databases

EnsemblBacteriaiABG18273; ABG18273; YPN_1944.
EEO76570; EEO76570; YP516_2164.
GeneIDi4122717.
KEGGiypn:YPN_1944.
PATRICi18603372. VBIYerPes46733_2346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000305 Genomic DNA. Translation: ABG18273.1 .
ACNQ01000011 Genomic DNA. Translation: EEO76570.1 .
RefSeqi YP_647873.1. NC_008149.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 377628.YPN_1944.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG18273 ; ABG18273 ; YPN_1944 .
EEO76570 ; EEO76570 ; YP516_2164 .
GeneIDi 4122717.
KEGGi ypn:YPN_1944.
PATRICi 18603372. VBIYerPes46733_2346.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000279190.
KOi K01775.
OMAi QQIPCVA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci YPES377628:GIXK-2005-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Nepal516Imported.
  3. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516.
  4. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516Imported.

Entry informationi

Entry nameiQ1CIA7_YERPN
AccessioniPrimary (citable) accession number: Q1CIA7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi