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Q1CI09

- PYRC_YERPN

UniProt

Q1CI09 - PYRC_YERPN

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Protein

Dihydroorotase

Gene
pyrC, YPN_2042, YP516_2274
Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Zinc 1; via tele nitrogen By similarity
Metal bindingi19 – 191Zinc 1; via tele nitrogen By similarity
Metal bindingi103 – 1031Zinc 1; via carbamate group By similarity
Metal bindingi103 – 1031Zinc 2; via carbamate group By similarity
Metal bindingi140 – 1401Zinc 2; via pros nitrogen By similarity
Metal bindingi178 – 1781Zinc 2; via tele nitrogen By similarity
Metal bindingi251 – 2511Zinc 1 By similarity

GO - Molecular functioni

  1. dihydroorotase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYPES377628:GIXK-2103-MONOMER.
UniPathwayiUPA00070; UER00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotase (EC:3.5.2.3)
Short name:
DHOase
Gene namesi
Name:pyrC
Ordered Locus Names:YPN_2042
ORF Names:YP516_2274
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000008936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348DihydroorotaseUniRule annotationPRO_1000024075Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031N6-carboxylysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi377628.YPN_2042.

Structurei

3D structure databases

ProteinModelPortaliQ1CI09.
SMRiQ1CI09. Positions 6-347.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0418.
HOGENOMiHOG000256259.
KOiK01465.
OMAiLKRNVHQ.
OrthoDBiEOG6TFCMH.

Family and domain databases

HAMAPiMF_00219. PyrC_type1.
InterProiIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsiTIGR00856. pyrC_dimer. 1 hit.
PROSITEiPS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1CI09-1 [UniParc]FASTAAdd to Basket

« Hide

MTAQPQTLKI RRPDDWHIHL RDDEMLSTVL PYTSEVFARA IVMPNLAQPI    50
TTVASAIAYR ERILAAVPAG HKFTPLMTCY LTNSLDAKEL TTGFEQGVFT 100
AAKLYPANAT TNSTHGVSDI PAIYPLFEQM QKIGMPLLIH GEVTDAAVDI 150
FDREARFIDQ ILEPIRQKFP ELKIVFEHIT TKDAADYVLA GNRFLGATVT 200
PQHLMFNRNH MLVGGIRPHL FCLPILKRST HQQALRAAVA SGSDRFFLGT 250
DSAPHAKHRK ESSCGCAGVF NAPAALPAYA SVFEELNALQ HLEAFCALNG 300
PRFYGLPVND DVVELVRTPF LQPEEIPLGN ESVIPFLAGQ TLNWSVKR 348
Length:348
Mass (Da):38,542
Last modified:July 11, 2006 - v1
Checksum:iB9215D6E02697221
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000305 Genomic DNA. Translation: ABG18371.1.
ACNQ01000012 Genomic DNA. Translation: EEO76520.1.
RefSeqiYP_647971.1. NC_008149.1.

Genome annotation databases

EnsemblBacteriaiABG18371; ABG18371; YPN_2042.
EEO76520; EEO76520; YP516_2274.
GeneIDi4126092.
KEGGiypn:YPN_2042.
PATRICi18603582. VBIYerPes46733_2451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000305 Genomic DNA. Translation: ABG18371.1 .
ACNQ01000012 Genomic DNA. Translation: EEO76520.1 .
RefSeqi YP_647971.1. NC_008149.1.

3D structure databases

ProteinModelPortali Q1CI09.
SMRi Q1CI09. Positions 6-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 377628.YPN_2042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG18371 ; ABG18371 ; YPN_2042 .
EEO76520 ; EEO76520 ; YP516_2274 .
GeneIDi 4126092.
KEGGi ypn:YPN_2042.
PATRICi 18603582. VBIYerPes46733_2451.

Phylogenomic databases

eggNOGi COG0418.
HOGENOMi HOG000256259.
KOi K01465.
OMAi LKRNVHQ.
OrthoDBi EOG6TFCMH.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00117 .
BioCyci YPES377628:GIXK-2103-MONOMER.

Family and domain databases

HAMAPi MF_00219. PyrC_type1.
InterProi IPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001237. DHOdimr. 1 hit.
TIGRFAMsi TIGR00856. pyrC_dimer. 1 hit.
PROSITEi PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516.
  2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPYRC_YERPN
AccessioniPrimary (citable) accession number: Q1CI09
Secondary accession number(s): C4GU08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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