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Q1CI09

- PYRC_YERPN

UniProt

Q1CI09 - PYRC_YERPN

Protein

Dihydroorotase

Gene

pyrC

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi17 – 171Zinc 1; via tele nitrogenUniRule annotation
    Metal bindingi19 – 191Zinc 1; via tele nitrogenUniRule annotation
    Metal bindingi103 – 1031Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi103 – 1031Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi140 – 1401Zinc 2; via pros nitrogenUniRule annotation
    Metal bindingi178 – 1781Zinc 2; via tele nitrogenUniRule annotation
    Metal bindingi251 – 2511Zinc 1UniRule annotation

    GO - Molecular functioni

    1. dihydroorotase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    2. pyrimidine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYPES377628:GIXK-2103-MONOMER.
    UniPathwayiUPA00070; UER00117.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DihydroorotaseUniRule annotation (EC:3.5.2.3UniRule annotation)
    Short name:
    DHOaseUniRule annotation
    Gene namesi
    Name:pyrCUniRule annotation
    Ordered Locus Names:YPN_2042
    ORF Names:YP516_2274
    OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
    Taxonomic identifieri377628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000008936: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348DihydroorotasePRO_1000024075Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei103 – 1031N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi377628.YPN_2042.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1CI09.
    SMRiQ1CI09. Positions 6-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0418.
    HOGENOMiHOG000256259.
    KOiK01465.
    OMAiLKRNVHQ.
    OrthoDBiEOG6TFCMH.

    Family and domain databases

    HAMAPiMF_00219. PyrC_type1.
    InterProiIPR006680. Amidohydro_1.
    IPR004721. DHOdimr.
    IPR002195. Dihydroorotase_CS.
    [Graphical view]
    PfamiPF01979. Amidohydro_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001237. DHOdimr. 1 hit.
    TIGRFAMsiTIGR00856. pyrC_dimer. 1 hit.
    PROSITEiPS00483. DIHYDROOROTASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1CI09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAQPQTLKI RRPDDWHIHL RDDEMLSTVL PYTSEVFARA IVMPNLAQPI    50
    TTVASAIAYR ERILAAVPAG HKFTPLMTCY LTNSLDAKEL TTGFEQGVFT 100
    AAKLYPANAT TNSTHGVSDI PAIYPLFEQM QKIGMPLLIH GEVTDAAVDI 150
    FDREARFIDQ ILEPIRQKFP ELKIVFEHIT TKDAADYVLA GNRFLGATVT 200
    PQHLMFNRNH MLVGGIRPHL FCLPILKRST HQQALRAAVA SGSDRFFLGT 250
    DSAPHAKHRK ESSCGCAGVF NAPAALPAYA SVFEELNALQ HLEAFCALNG 300
    PRFYGLPVND DVVELVRTPF LQPEEIPLGN ESVIPFLAGQ TLNWSVKR 348
    Length:348
    Mass (Da):38,542
    Last modified:July 11, 2006 - v1
    Checksum:iB9215D6E02697221
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG18371.1.
    ACNQ01000012 Genomic DNA. Translation: EEO76520.1.
    RefSeqiYP_647971.1. NC_008149.1.

    Genome annotation databases

    EnsemblBacteriaiABG18371; ABG18371; YPN_2042.
    EEO76520; EEO76520; YP516_2274.
    GeneIDi4126092.
    KEGGiypn:YPN_2042.
    PATRICi18603582. VBIYerPes46733_2451.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG18371.1 .
    ACNQ01000012 Genomic DNA. Translation: EEO76520.1 .
    RefSeqi YP_647971.1. NC_008149.1.

    3D structure databases

    ProteinModelPortali Q1CI09.
    SMRi Q1CI09. Positions 6-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 377628.YPN_2042.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG18371 ; ABG18371 ; YPN_2042 .
    EEO76520 ; EEO76520 ; YP516_2274 .
    GeneIDi 4126092.
    KEGGi ypn:YPN_2042.
    PATRICi 18603582. VBIYerPes46733_2451.

    Phylogenomic databases

    eggNOGi COG0418.
    HOGENOMi HOG000256259.
    KOi K01465.
    OMAi LKRNVHQ.
    OrthoDBi EOG6TFCMH.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00117 .
    BioCyci YPES377628:GIXK-2103-MONOMER.

    Family and domain databases

    HAMAPi MF_00219. PyrC_type1.
    InterProi IPR006680. Amidohydro_1.
    IPR004721. DHOdimr.
    IPR002195. Dihydroorotase_CS.
    [Graphical view ]
    Pfami PF01979. Amidohydro_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001237. DHOdimr. 1 hit.
    TIGRFAMsi TIGR00856. pyrC_dimer. 1 hit.
    PROSITEi PS00483. DIHYDROOROTASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
      Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
      J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516.
    2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
      Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPYRC_YERPN
    AccessioniPrimary (citable) accession number: Q1CI09
    Secondary accession number(s): C4GU08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3