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Protein

3-ketoacyl-CoA thiolase

Gene

fadI

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Acyl-thioester intermediateUniRule annotation1
Active sitei392Proton acceptorUniRule annotation1
Active sitei422Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
ACSsUniRule annotation
Acetyl-CoA acyltransferaseUniRule annotation
Acyl-CoA ligaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadIUniRule annotation
Ordered Locus Names:YPN_2201
ORF Names:YP516_2466
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000008936 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000695241 – 4363-ketoacyl-CoA thiolaseAdd BLAST436

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1CHK1.
SMRiQ1CHK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000012240.
KOiK00632.
OMAiMTAFPEP.

Family and domain databases

CDDicd00751. thiolase. 1 hit.
Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01618. FadI. 1 hit.
InterProiView protein in InterPro
IPR012806. Ac-CoA_C-AcTrfase_FadI.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
PANTHERiPTHR18919:SF128. PTHR18919:SF128. 1 hit.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02446. FadI. 1 hit.
PROSITEiView protein in PROSITE
PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CHK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPLPLVTR QGDRIVIVNG LRTPFAKQAT AYHGVPAVDL GKIVVSELLA
60 70 80 90 100
RSGISSELID QLVFGQVVQM PEAPNIAREI VLGTGMSVHT DAYSVSRACA
110 120 130 140 150
TSFQAVANVA ESIIAGSVDI AIAGGADSSS VLPIGVSKAL ARTLVDANKA
160 170 180 190 200
RSLSQKLKLF SRLRLRDLLP VAPAVAEYST GLRMGDTAEQ MAKTYGISRE
210 220 230 240 250
DQDALALRSH QLAAEAWQQG WLHDEVMTAY IPPYREAIIE DNNIRKDSTL
260 270 280 290 300
AQYAKLRPAF DRQHGSVTAA NSTPLTDGAA AVLMMSESKA KALGLPPLGY
310 320 330 340 350
LRSFAFSAID VWQDMLLGPS YATPLALDRA GITLADLTLI DMHEAFAAQT
360 370 380 390 400
LANLKMFASD TFAREKLGRS QAIGEVDMSK FNVLGGSIAY GHPFAATGAR
410 420 430
MITQTLNELR RRGGGLGLTT ACAAGGLGAA MILEVE
Length:436
Mass (Da):46,311
Last modified:July 11, 2006 - v1
Checksum:i34A94043B5931C49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG18529.1.
ACNQ01000013 Genomic DNA. Translation: EEO76269.1.
RefSeqiWP_002209704.1. NZ_ACNQ01000013.1.

Genome annotation databases

EnsemblBacteriaiABG18529; ABG18529; YPN_2201.
EEO76269; EEO76269; YP516_2466.
KEGGiypn:YPN_2201.

Similar proteinsi

Entry informationi

Entry nameiFADI_YERPN
AccessioniPrimary (citable) accession number: Q1CHK1
Secondary accession number(s): C4GU82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 11, 2006
Last modified: August 30, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families