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Protein

Ferrous iron permease EfeU

Gene

efeU

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Uptake of Fe2+ ions across the membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciYPES377628:GIXK-2334-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrous iron permease EfeU
Alternative name(s):
Fe(2+) ion permease EfeU
Ferrous iron uptake protein
Gene namesi
Name:efeU
Ordered Locus Names:YPN_2269
ORF Names:YP516_2550
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000008936 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11PeriplasmicSequence analysis
Transmembranei2 – 2221HelicalSequence analysisAdd
BLAST
Topological domaini23 – 3513CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Topological domaini57 – 6913PeriplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Topological domaini91 – 11828CytoplasmicSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 1478PeriplasmicSequence analysis
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Topological domaini169 – 17911CytoplasmicSequence analysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Topological domaini201 – 24444PeriplasmicSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 28217CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Ferrous iron permease EfeUPRO_0000277551Add
BLAST

Interactioni

Subunit structurei

Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1CHD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000236918.
KOiK07243.
OMAiRWTSLFI.
OrthoDBiEOG62ZHSM.

Family and domain databases

InterProiIPR004923. FTR1/Fip1/EfeU.
[Graphical view]
PANTHERiPTHR31632. PTHR31632. 1 hit.
PfamiPF03239. FTR1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1CHD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVPFLIMFR EGLEAALIVS LIASYLKRTQ RGQWMGAVWV GVVVAAVLCL
60 70 80 90 100
AIGIFINETT GEFPQKQQEL FEGIIAVVAV CILTYMVFWM RKVSKSVKVH
110 120 130 140 150
LEGAIDNALN SGRGQGWALV AMVFFAVARE GLESVFFLLA AFQQDVGIGA
160 170 180 190 200
PIGAILGLVC AILVGMAIYW GGVKLHLAKF FKWTSLFILF VAAGLAAGAI
210 220 230 240 250
RAFHEAGLWN HFQDIAFDLT DVLSTHSLLG TFLEGMFGYQ EAPTVSEVSV
260 270 280
YFIYLIPALI LFFLPPRSTA GSAIAAARKI NP
Length:282
Mass (Da):30,688
Last modified:July 11, 2006 - v1
Checksum:iC6D394DB1BD68055
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG18597.1.
ACNQ01000013 Genomic DNA. Translation: EEO76348.1.
RefSeqiWP_002211165.1. NZ_ACNQ01000013.1.

Genome annotation databases

EnsemblBacteriaiABG18597; ABG18597; YPN_2269.
EEO76348; EEO76348; YP516_2550.
KEGGiypn:YPN_2269.
PATRICi18604139. VBIYerPes46733_2724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG18597.1.
ACNQ01000013 Genomic DNA. Translation: EEO76348.1.
RefSeqiWP_002211165.1. NZ_ACNQ01000013.1.

3D structure databases

ProteinModelPortaliQ1CHD3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG18597; ABG18597; YPN_2269.
EEO76348; EEO76348; YP516_2550.
KEGGiypn:YPN_2269.
PATRICi18604139. VBIYerPes46733_2724.

Phylogenomic databases

HOGENOMiHOG000236918.
KOiK07243.
OMAiRWTSLFI.
OrthoDBiEOG62ZHSM.

Enzyme and pathway databases

BioCyciYPES377628:GIXK-2334-MONOMER.

Family and domain databases

InterProiIPR004923. FTR1/Fip1/EfeU.
[Graphical view]
PANTHERiPTHR31632. PTHR31632. 1 hit.
PfamiPF03239. FTR1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516.
  2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516.

Entry informationi

Entry nameiEFEU_YERPN
AccessioniPrimary (citable) accession number: Q1CHD3
Secondary accession number(s): C4GUG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 11, 2006
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.