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Q1CHC4

- DCYD_YERPN

UniProt

Q1CHC4 - DCYD_YERPN

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Protein
D-cysteine desulfhydrase
Gene
dcyD, YPN_2278, YP516_2560
Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine By similarity.UniRule annotation

Catalytic activityi

D-cysteine + H2O = H2S + NH3 + pyruvate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. D-cysteine desulfhydrase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-amino acid metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYPES377628:GIXK-2343-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-cysteine desulfhydrase (EC:4.4.1.15)
Gene namesi
Name:dcyD
Ordered Locus Names:YPN_2278
ORF Names:YP516_2560
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000008936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330D-cysteine desulfhydraseUniRule annotation
PRO_1000064271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ1CHC4.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi377628.YPN_2278.

Structurei

3D structure databases

ProteinModelPortaliQ1CHC4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2515.
HOGENOMiHOG000022459.
KOiK05396.
OMAiPYLVPIG.
OrthoDBiEOG6FBX0P.

Family and domain databases

HAMAPiMF_01045. D_Cys_desulfhydr.
InterProiIPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01275. ACC_deam_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CHC4-1 [UniParc]FASTAAdd to Basket

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MTLQQKLTQF PRLDLVGNAT PLEKLSRLSD YLGREIYIKR DDVTPVALGG    50
NKLRKLEFLA ADALRQGADT LVTAGAIQSN HVRQTAAVAA KLGLHCVALL 100
ENPIGTEQAN YLTNGNRLLL DLFNVDVVMC EALNDPNQQL AELATRVEAQ 150
GFRPYVVPIG GSNALGALGY VQCSLEIAAQ AAGNVAFSSV VVASGSAGTH 200
AGLAVGLQQL LPDAELIGVT VSRSADEQRP KVAQIQQALA TSLGMTDPLA 250
KITLWDSYFA PQYGMPNEEG IAAIKLLARL EGILLDPVYT GKAMAGLLDG 300
IEQQKFCDKG PILFIHTGGA PALFAYHPQV 330
Length:330
Mass (Da):35,039
Last modified:July 11, 2006 - v1
Checksum:iCDC974B8DBF26922
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000305 Genomic DNA. Translation: ABG18606.1.
ACNQ01000013 Genomic DNA. Translation: EEO76358.1.
RefSeqiYP_648206.1. NC_008149.1.

Genome annotation databases

EnsemblBacteriaiABG18606; ABG18606; YPN_2278.
EEO76358; EEO76358; YP516_2560.
GeneIDi4123294.
KEGGiypn:YPN_2278.
PATRICi18604161. VBIYerPes46733_2735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000305 Genomic DNA. Translation: ABG18606.1 .
ACNQ01000013 Genomic DNA. Translation: EEO76358.1 .
RefSeqi YP_648206.1. NC_008149.1.

3D structure databases

ProteinModelPortali Q1CHC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 377628.YPN_2278.

Proteomic databases

PRIDEi Q1CHC4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG18606 ; ABG18606 ; YPN_2278 .
EEO76358 ; EEO76358 ; YP516_2560 .
GeneIDi 4123294.
KEGGi ypn:YPN_2278.
PATRICi 18604161. VBIYerPes46733_2735.

Phylogenomic databases

eggNOGi COG2515.
HOGENOMi HOG000022459.
KOi K05396.
OMAi PYLVPIG.
OrthoDBi EOG6FBX0P.

Enzyme and pathway databases

BioCyci YPES377628:GIXK-2343-MONOMER.

Family and domain databases

HAMAPi MF_01045. D_Cys_desulfhydr.
InterProi IPR027278. ACCD_DCysDesulf.
IPR005966. D-Cys_desShydrase.
IPR023702. D_Cys_desulphydr_bac.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR01275. ACC_deam_rel. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516.
  2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDCYD_YERPN
AccessioniPrimary (citable) accession number: Q1CHC4
Secondary accession number(s): C4GUH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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