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Q1CFR7

- BETA_YERPN

UniProt

Q1CFR7 - BETA_YERPN

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciYPES377628:GIXK-2910-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:YPN_2836
ORF Names:YP516_3206
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000008936: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Oxygen-dependent choline dehydrogenasePRO_0000258940Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi377628.YPN_2836.

Structurei

3D structure databases

ProteinModelPortaliQ1CFR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1CFR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYDYIIIGA GSAGNVLAAR LTEDADVTVL LLEAGGPDYR LDFRTQMPAA
60 70 80 90 100
LAFPLQGKRY NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN
110 120 130 140 150
AMDFDHWASL SGLEDWSYLD CLPYFRKAET RDIGPNDFHG GEGPVSVTTP
160 170 180 190 200
KIGNNPLFHA MVAAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPKGRRAST
210 220 230 240 250
ARGYLDQARP RNNLTIITHA LTDRILFEGK RATGVRYLKG DAGTGQTAYA
260 270 280 290 300
RREVLLCGGA IASPQILQRS GIGPAELLQR LDIPLVQALP GVGENLQDHL
310 320 330 340 350
EMYLQYSCKQ PVSLYPALLW FNQPKIGIEW LFNGTGVGAS NQFEAGGFIR
360 370 380 390 400
SRDAFTWPNI QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRIQVK
410 420 430 440 450
SKDPRQHPSI LFNYMSSEQD WHEFRDAIRI TREIIAQPAL DPYRGREISP
460 470 480 490 500
GANVQNDDEL DAFIREHAET AYHPSCSCKM GDDKMAVVDG QGRVHGVQGL
510 520 530 540 550
RVVDASIMPQ IITGNLNATT IMIAEKIADR IRGCQPLAKS NAAYFIAGDT
560
PARTSPVRHS LPVTSYP
Length:567
Mass (Da):62,502
Last modified:July 11, 2006 - v1
Checksum:iF287BA9D18156166
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG19163.1.
ACNQ01000017 Genomic DNA. Translation: EEO75306.1.
RefSeqiYP_648763.1. NC_008149.1.

Genome annotation databases

EnsemblBacteriaiABG19163; ABG19163; YPN_2836.
EEO75306; EEO75306; YP516_3206.
GeneIDi4126037.
KEGGiypn:YPN_2836.
PATRICi18605466. VBIYerPes46733_3383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA. Translation: ABG19163.1 .
ACNQ01000017 Genomic DNA. Translation: EEO75306.1 .
RefSeqi YP_648763.1. NC_008149.1.

3D structure databases

ProteinModelPortali Q1CFR7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 377628.YPN_2836.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG19163 ; ABG19163 ; YPN_2836 .
EEO75306 ; EEO75306 ; YP516_3206 .
GeneIDi 4126037.
KEGGi ypn:YPN_2836.
PATRICi 18605466. VBIYerPes46733_3383.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci YPES377628:GIXK-2910-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nepal516.
  2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
    Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiBETA_YERPN
AccessioniPrimary (citable) accession number: Q1CFR7
Secondary accession number(s): C4GWK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3