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Q1CFR7

- BETA_YERPN

UniProt

Q1CFR7 - BETA_YERPN

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei473 – 4731UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 3330FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciYPES377628:GIXK-2910-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:YPN_2836
    ORF Names:YP516_3206
    OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
    Taxonomic identifieri377628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000008936: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Oxygen-dependent choline dehydrogenasePRO_0000258940Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi377628.YPN_2836.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1CFR7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1CFR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYDYIIIGA GSAGNVLAAR LTEDADVTVL LLEAGGPDYR LDFRTQMPAA    50
    LAFPLQGKRY NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN 100
    AMDFDHWASL SGLEDWSYLD CLPYFRKAET RDIGPNDFHG GEGPVSVTTP 150
    KIGNNPLFHA MVAAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPKGRRAST 200
    ARGYLDQARP RNNLTIITHA LTDRILFEGK RATGVRYLKG DAGTGQTAYA 250
    RREVLLCGGA IASPQILQRS GIGPAELLQR LDIPLVQALP GVGENLQDHL 300
    EMYLQYSCKQ PVSLYPALLW FNQPKIGIEW LFNGTGVGAS NQFEAGGFIR 350
    SRDAFTWPNI QYHFLPVAIN YNGSNAVKEH GFQAHVGSMR SPSRGRIQVK 400
    SKDPRQHPSI LFNYMSSEQD WHEFRDAIRI TREIIAQPAL DPYRGREISP 450
    GANVQNDDEL DAFIREHAET AYHPSCSCKM GDDKMAVVDG QGRVHGVQGL 500
    RVVDASIMPQ IITGNLNATT IMIAEKIADR IRGCQPLAKS NAAYFIAGDT 550
    PARTSPVRHS LPVTSYP 567
    Length:567
    Mass (Da):62,502
    Last modified:July 11, 2006 - v1
    Checksum:iF287BA9D18156166
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG19163.1.
    ACNQ01000017 Genomic DNA. Translation: EEO75306.1.
    RefSeqiYP_648763.1. NC_008149.1.

    Genome annotation databases

    EnsemblBacteriaiABG19163; ABG19163; YPN_2836.
    EEO75306; EEO75306; YP516_3206.
    GeneIDi4126037.
    KEGGiypn:YPN_2836.
    PATRICi18605466. VBIYerPes46733_3383.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG19163.1 .
    ACNQ01000017 Genomic DNA. Translation: EEO75306.1 .
    RefSeqi YP_648763.1. NC_008149.1.

    3D structure databases

    ProteinModelPortali Q1CFR7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 377628.YPN_2836.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG19163 ; ABG19163 ; YPN_2836 .
    EEO75306 ; EEO75306 ; YP516_3206 .
    GeneIDi 4126037.
    KEGGi ypn:YPN_2836.
    PATRICi 18605466. VBIYerPes46733_3383.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci YPES377628:GIXK-2910-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
      Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
      J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516.
    2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
      Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiBETA_YERPN
    AccessioniPrimary (citable) accession number: Q1CFR7
    Secondary accession number(s): C4GWK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3