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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (YPN_2439)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:YPN_2852
ORF Names:YP516_3225
OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
Taxonomic identifieri377628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000008936 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914761 – 3346-phosphogluconolactonaseAdd BLAST334

Structurei

3D structure databases

ProteinModelPortaliQ1CFQ1
SMRiQ1CFQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

Q1CFQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQAVYVASP DSQQIHVWQL DSAGELTLLQ TVDVPGQVQP MAISPNQRHL
60 70 80 90 100
YVGVRPDFGI VSYHIADDGT LTAAGMAPLP GSPTHIDTDR QGRFLFSASY
110 120 130 140 150
SFNCVSISPI DTHGVVQAPI QQLDDLPAPH SANIDPTNQI LLVPCLKEDK
160 170 180 190 200
VRLFDLSAEG QLTPHAQADI TVAAGAGPRH MAFHPNHQVA YCVNELNSSV
210 220 230 240 250
DVYQISNNGQ EYHLVQSLDA MPADFTGTRW AADIHITPNG RYLYISDRTA
260 270 280 290 300
NLLGIFTVSE DGRVISLVGH HLTEAQPRGF NIDHSGNFLI ASGQKSDHIE
310 320 330
VYRIDQNTGE LTTLKRYPVG KGPMWVSIRG AQNS
Length:334
Mass (Da):36,446
Last modified:July 11, 2006 - v1
Checksum:i4BDAC511EF8E0F06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000305 Genomic DNA Translation: ABG19179.1
ACNQ01000017 Genomic DNA Translation: EEO75323.1
RefSeqiWP_002210760.1, NZ_ACNQ01000017.1

Genome annotation databases

EnsemblBacteriaiABG19179; ABG19179; YPN_2852
EEO75323; EEO75323; YP516_3225
KEGGiypn:YPN_2852

Similar proteinsi

Entry informationi

Entry namei6PGL_YERPN
AccessioniPrimary (citable) accession number: Q1CFQ1
Secondary accession number(s): C4GWM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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