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Q1CFF9

- LPXA_YERPN

UniProt

Q1CFF9 - LPXA_YERPN

Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciYPES377628:GIXK-3028-MONOMER.
    UniPathwayiUPA00359; UER00477.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
    Short name:
    UDP-N-acetylglucosamine acyltransferaseUniRule annotation
    Gene namesi
    Name:lpxAUniRule annotation
    Ordered Locus Names:YPN_2944
    ORF Names:YP516_3334
    OrganismiYersinia pestis bv. Antiqua (strain Nepal516)
    Taxonomic identifieri377628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000008936: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferasePRO_0000302615Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi377628.YPN_2944.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1CFF9.
    SMRiQ1CFF9. Positions 1-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1043.
    HOGENOMiHOG000294326.
    KOiK00677.
    OMAiDCQDKKY.
    OrthoDBiEOG6F81P1.

    Family and domain databases

    Gene3Di1.20.1180.10. 1 hit.
    HAMAPiMF_00387. LpxA.
    InterProiIPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 4 hits.
    [Graphical view]
    PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1CFF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIDKTAFIHP SSIVEEGAII GAGVYIGPFC IVGSQVEIGA GTELKSHVVV    50
    NGITKIGCDN QIYQFASIGE ANQDLKYAGE PTRVEVGDRN RIRESVTIHR 100
    GTTQGGGVTK VGCDNLLMVN THVAHDCVIG NRCILANNAA LGGHVEIDDY 150
    AIIGGMTAIH QFCVIGAHVM VGGCSGITQD VPPFVIAQGN HATPFGINIE 200
    GLKRRGFDKE SLHAIRSAYK LLYRSGRTLD EVKPEIAELA EQYPVVKAFN 250
    DFFARSTRGI IR 262
    Length:262
    Mass (Da):28,117
    Last modified:July 11, 2006 - v1
    Checksum:iC749FF7F53216DF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG19271.1.
    ACNQ01000017 Genomic DNA. Translation: EEO75420.1.
    RefSeqiYP_648871.1. NC_008149.1.

    Genome annotation databases

    EnsemblBacteriaiABG19271; ABG19271; YPN_2944.
    EEO75420; EEO75420; YP516_3334.
    GeneIDi4124963.
    KEGGiypn:YPN_2944.
    PATRICi18605720. VBIYerPes46733_3501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG19271.1 .
    ACNQ01000017 Genomic DNA. Translation: EEO75420.1 .
    RefSeqi YP_648871.1. NC_008149.1.

    3D structure databases

    ProteinModelPortali Q1CFF9.
    SMRi Q1CFF9. Positions 1-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 377628.YPN_2944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG19271 ; ABG19271 ; YPN_2944 .
    EEO75420 ; EEO75420 ; YP516_3334 .
    GeneIDi 4124963.
    KEGGi ypn:YPN_2944.
    PATRICi 18605720. VBIYerPes46733_3501.

    Phylogenomic databases

    eggNOGi COG1043.
    HOGENOMi HOG000294326.
    KOi K00677.
    OMAi DCQDKKY.
    OrthoDBi EOG6F81P1.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00477 .
    BioCyci YPES377628:GIXK-3028-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1180.10. 1 hit.
    HAMAPi MF_00387. LpxA.
    InterProi IPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
      Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
      J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516.
    2. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
      Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiLPXA_YERPN
    AccessioniPrimary (citable) accession number: Q1CFF9
    Secondary accession number(s): C4GWX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3