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Q1CEA4

- Q1CEA4_YERPN

UniProt

Q1CEA4 - Q1CEA4_YERPN

Protein

Alanine racemase

Gene

alr

Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei129 – 1291SubstrateUniRule annotation
    Active sitei254 – 2541Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei302 – 3021Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciYPES377628:GIXK-3443-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:YPN_3349Imported
    ORF Names:YP516_3806Imported
    OrganismiYersinia pestis bv. Antiqua (strain Nepal516)Imported
    Taxonomic identifieri377628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000008936: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi377628.YPN_3349.

    Structurei

    3D structure databases

    SMRiQ1CEA4. Positions 1-357.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031446.
    KOiK01775.
    OMAiIYSHLAL.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1CEA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAATAVIDR HALRHNLQQI RRLAPQSRLV AVVKANAYGH GLLAAAHTLQ    50
    DADCYGVARI SEALMLRAGG IVKPILLLEG FFDAEDLPVL VANHIETAVH 100
    SLEQLVALEA ATLSAPINVW MKLDTGMHRL GVRPDQAEAF YQRLSACRNV 150
    IQPVNIMSHF SRADEPEVAA TQQQLACFDA FAAGKPGKQS IAASGGILRW 200
    PQAHRDWVRP GIVLYGVSPF DAPYGRDFGL LPAMTLKSSL IAVREHKAGE 250
    SVGYGGTWVS ERDTRLGVIA IGYGDGYPRS APSGTPVWLN GREVSIVGRV 300
    SMDMISIDLG PESTDKVGDE ALMWGAELPV ERVAACTGIS AYELITNLTS 350
    RVAMEYLGE 359
    Length:359
    Mass (Da):38,731
    Last modified:July 11, 2006 - v1
    Checksum:i5A12985B1FE6964F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG19676.1.
    ACNQ01000017 Genomic DNA. Translation: EEO75867.1.
    RefSeqiYP_649276.1. NC_008149.1.

    Genome annotation databases

    EnsemblBacteriaiABG19676; ABG19676; YPN_3349.
    EEO75867; EEO75867; YP516_3806.
    GeneIDi4125899.
    KEGGiypn:YPN_3349.
    PATRICi18606675. VBIYerPes46733_3971.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000305 Genomic DNA. Translation: ABG19676.1 .
    ACNQ01000017 Genomic DNA. Translation: EEO75867.1 .
    RefSeqi YP_649276.1. NC_008149.1.

    3D structure databases

    SMRi Q1CEA4. Positions 1-357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 377628.YPN_3349.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG19676 ; ABG19676 ; YPN_3349 .
    EEO75867 ; EEO75867 ; YP516_3806 .
    GeneIDi 4125899.
    KEGGi ypn:YPN_3349.
    PATRICi 18606675. VBIYerPes46733_3971.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031446.
    KOi K01775.
    OMAi IYSHLAL.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci YPES377628:GIXK-3443-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
      Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
      J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Nepal516Imported.
    3. "Yersinia pestis Nepal516A whole genome shotgun sequencing project."
      Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nepal516Imported.

    Entry informationi

    Entry nameiQ1CEA4_YERPN
    AccessioniPrimary (citable) accession number: Q1CEA4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3