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Q1CEA4 (Q1CEA4_YERPN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase HAMAP-Rule MF_01201

EC=5.1.1.1 HAMAP-Rule MF_01201
Gene names
Name:alr EMBL EEO75867.1
Ordered Locus Names:YPN_3349 EMBL ABG19676.1
ORF Names:YP516_3806 EMBL EEO75867.1
OrganismYersinia pestis bv. Antiqua (strain Nepal516) [Complete proteome] [HAMAP] EMBL ABG19676.1
Taxonomic identifier377628 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. SAAS SAAS020622 HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS020622 HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site341Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2541Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1291Substrate By similarity HAMAP-Rule MF_01201
Binding site3021Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue341N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
Q1CEA4 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 5A12985B1FE6964F

FASTA35938,731
        10         20         30         40         50         60 
MKAATAVIDR HALRHNLQQI RRLAPQSRLV AVVKANAYGH GLLAAAHTLQ DADCYGVARI 

        70         80         90        100        110        120 
SEALMLRAGG IVKPILLLEG FFDAEDLPVL VANHIETAVH SLEQLVALEA ATLSAPINVW 

       130        140        150        160        170        180 
MKLDTGMHRL GVRPDQAEAF YQRLSACRNV IQPVNIMSHF SRADEPEVAA TQQQLACFDA 

       190        200        210        220        230        240 
FAAGKPGKQS IAASGGILRW PQAHRDWVRP GIVLYGVSPF DAPYGRDFGL LPAMTLKSSL 

       250        260        270        280        290        300 
IAVREHKAGE SVGYGGTWVS ERDTRLGVIA IGYGDGYPRS APSGTPVWLN GREVSIVGRV 

       310        320        330        340        350 
SMDMISIDLG PESTDKVGDE ALMWGAELPV ERVAACTGIS AYELITNLTS RVAMEYLGE 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
Chain P.S., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nepal516 EMBL ABG19676.1.
[2]"Complete sequence of chromosome of Yersinia pestis Nepal516."
US DOE Joint Genome Institute
Barry K., Lucas S., Lapidus A., Copeland A., Detter J.C., Glavina del Rio T., Hammon N., Dalin E., Tice H., Pitluck S., Chain P., Hu P., Malfatti S.A., Radnedge L., Vergez L.M., Larimer F., Land M., Hauser L. expand/collapse author list , Worsham P., Chu M.C., Andersen G., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Nepal516 EMBL ABG19676.1.
[3]"Yersinia pestis Nepal516A whole genome shotgun sequencing project."
Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nepal516.
[4]"Yersinia pestis Nepal516A whole genome shotgun sequencing project."
Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nepal516 EMBL EEO75867.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000305 Genomic DNA. Translation: ABG19676.1.
ACNQ01000017 Genomic DNA. Translation: EEO75867.1.
RefSeqYP_649276.1. NC_008149.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING377628.YPN_3349.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG19676; ABG19676; YPN_3349.
EEO75867; EEO75867; YP516_3806.
GeneID4125899.
KEGGypn:YPN_3349.
PATRIC18606675. VBIYerPes46733_3971.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031446.
KOK01775.
OMAIYSHLAL.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycYPES377628:GIXK-3443-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1CEA4_YERPN
AccessionPrimary (citable) accession number: Q1CEA4
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)