Alanine racemase - Yersinia pestis bv. Antiqua (strain Nepal516)

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Q1CEA4 (Q1CEA4_YERPN) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 65. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Alanine racemase HAMAP-Rule MF_01201
EC=5.1.1.1 HAMAP-Rule MF_01201

Gene names

Name:	alr EMBL EEO75867.1
Ordered Locus Names:	YPN_3349 EMBL ABG19676.1
ORF Names:	YP516_3806 EMBL EEO75867.1

Organism

Yersinia pestis bv. Antiqua (strain Nepal516) [Complete proteome] [HAMAP] EMBL ABG19676.1

Taxonomic identifier

377628 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia ›

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201
Catalytic activity	L-alanine = D-alanine. SAAS SAAS020622 HAMAP-Rule MF_01201
Cofactor	Pyridoxal phosphate By similarity. SAAS SAAS020622 HAMAP-Rule MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201
Sequence similarities	Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Ontologies

Keywords
Ligand	Pyridoxal phosphate SAAS SAAS020622 HAMAP-Rule MF_01201
Molecular function	Isomerase SAAS SAAS020622 HAMAP-Rule MF_01201 EMBL ABG19676.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Active site

Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201

Active site

254

Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201

Binding site

129

Substrate By similarity HAMAP-Rule MF_01201

Binding site

302

Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue

N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence

Length

Mass (Da)

Tools

Q1CEA4 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 5A12985B1FE6964F
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FASTA

359

38,731

        10         20         30         40         50         60 
MKAATAVIDR HALRHNLQQI RRLAPQSRLV AVVKANAYGH GLLAAAHTLQ DADCYGVARI 

        70         80         90        100        110        120 
SEALMLRAGG IVKPILLLEG FFDAEDLPVL VANHIETAVH SLEQLVALEA ATLSAPINVW 

       130        140        150        160        170        180 
MKLDTGMHRL GVRPDQAEAF YQRLSACRNV IQPVNIMSHF SRADEPEVAA TQQQLACFDA 

       190        200        210        220        230        240 
FAAGKPGKQS IAASGGILRW PQAHRDWVRP GIVLYGVSPF DAPYGRDFGL LPAMTLKSSL 

       250        260        270        280        290        300 
IAVREHKAGE SVGYGGTWVS ERDTRLGVIA IGYGDGYPRS APSGTPVWLN GREVSIVGRV 

       310        320        330        340        350 
SMDMISIDLG PESTDKVGDE ALMWGAELPV ERVAACTGIS AYELITNLTS RVAMEYLGE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen." Chain P.S., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L. J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nepal516 EMBL ABG19676.1.
[2]	"Complete sequence of chromosome of Yersinia pestis Nepal516." US DOE Joint Genome Institute Barry K., Lucas S., Lapidus A., Copeland A., Detter J.C., Glavina del Rio T., Hammon N., Dalin E., Tice H., Pitluck S., Chain P., Hu P., Malfatti S.A., Radnedge L., Vergez L.M., Larimer F., Land M., Hauser L. , Worsham P., Chu M.C., Andersen G., Richardson P. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Nepal516 EMBL ABG19676.1.
[3]	"Yersinia pestis Nepal516A whole genome shotgun sequencing project." Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nepal516 EMBL EEO75867.1.
[4]	"Yersinia pestis Nepal516A whole genome shotgun sequencing project." Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nepal516.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000305 Genomic DNA. Translation: ABG19676.1. ACNQ01000017 Genomic DNA. Translation: EEO75867.1.
RefSeq	YP_649276.1. NC_008149.1.
3D structure databases
SMR	Q1CEA4. Positions 1-357.
ModBase	Search...
Protein-protein interaction databases
STRING	377628.YPN_3349.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG19676; ABG19676; YPN_3349. EEO75867; EEO75867; YP516_3806.
GeneID	4125899.
KEGG	ypn:YPN_3349.
PATRIC	18606675. VBIYerPes46733_3971.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0787.
HOGENOM	HOG000031446.
KO	K01775.
OMA	IRLPKAY.
ProtClustDB	PRK00053.
Enzyme and pathway databases
BioCyc	YPES377628:GIXK-3443-MONOMER.
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1CEA4_YERPN

Accession

Primary (citable) accession number: Q1CEA4

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	May 29, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information