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Q1CBX8

- MSRA_YERPA

UniProt

Q1CBX8 - MSRA_YERPA

Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

    Catalytic activityi

    Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
    L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521UniRule annotation

    GO - Molecular functioni

    1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular protein modification process Source: UniProtKB-HAMAP
    2. protein repair Source: InterPro
    3. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciYPES360102:GHZU-83-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
    Short name:
    Protein-methionine-S-oxide reductaseUniRule annotation
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductaseUniRule annotation
    Short name:
    Peptide Met(O) reductaseUniRule annotation
    Gene namesi
    Name:msrAUniRule annotation
    Ordered Locus Names:YPA_0075
    OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
    Taxonomic identifieri360102 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001971: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Peptide methionine sulfoxide reductase MsrAPRO_1000068375Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360102.YPA_0075.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1CBX8.
    SMRiQ1CBX8. Positions 5-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0225.
    HOGENOMiHOG000263862.
    KOiK07304.
    OMAiYAGGQTP.
    OrthoDBiEOG6091JX.

    Family and domain databases

    Gene3Di3.30.1060.10. 1 hit.
    HAMAPiMF_01401. MsrA.
    InterProiIPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view]
    PANTHERiPTHR10173. PTHR10173. 1 hit.
    PfamiPF01625. PMSR. 1 hit.
    [Graphical view]
    SUPFAMiSSF55068. SSF55068. 1 hit.
    TIGRFAMsiTIGR00401. msrA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1CBX8-1 [UniParc]FASTAAdd to Basket

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    MQNVDNTAVI DAANALPGRL TSIPVSPLHA VHGHSMTYIP EGMDLAFFAM    50
    GCFWGAERLF WQQPGVYSTA AGYSGGHTPN PTYHEVCSGR TGHAEVVRVV 100
    FDPAVISYQQ LLQIFWENHD PAQGMRQGGD VGTQYRSAIY VLTPEQEEQA 150
    HKSRERFQQA MEKAGDQRVI TSEITVALPF YYAEDDHQQY LHKNPHGYCG 200
    LGGIGVCLPP NV 212
    Length:212
    Mass (Da):23,434
    Last modified:July 11, 2006 - v1
    Checksum:i053AFEE64208A3B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000308 Genomic DNA. Translation: ABG12044.1.
    RefSeqiYP_649989.1. NC_008150.1.

    Genome annotation databases

    EnsemblBacteriaiABG12044; ABG12044; YPA_0075.
    GeneIDi4120390.
    KEGGiypa:YPA_0075.
    PATRICi18578934. VBIYerPes1796_0320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000308 Genomic DNA. Translation: ABG12044.1 .
    RefSeqi YP_649989.1. NC_008150.1.

    3D structure databases

    ProteinModelPortali Q1CBX8.
    SMRi Q1CBX8. Positions 5-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360102.YPA_0075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG12044 ; ABG12044 ; YPA_0075 .
    GeneIDi 4120390.
    KEGGi ypa:YPA_0075.
    PATRICi 18578934. VBIYerPes1796_0320.

    Phylogenomic databases

    eggNOGi COG0225.
    HOGENOMi HOG000263862.
    KOi K07304.
    OMAi YAGGQTP.
    OrthoDBi EOG6091JX.

    Enzyme and pathway databases

    BioCyci YPES360102:GHZU-83-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1060.10. 1 hit.
    HAMAPi MF_01401. MsrA.
    InterProi IPR028427. Met_Sox_Rdtase.
    IPR002569. Met_Sox_Rdtase_MsrA.
    [Graphical view ]
    PANTHERi PTHR10173. PTHR10173. 1 hit.
    Pfami PF01625. PMSR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55068. SSF55068. 1 hit.
    TIGRFAMsi TIGR00401. msrA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
      Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
      J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Antiqua.

    Entry informationi

    Entry nameiMSRA_YERPA
    AccessioniPrimary (citable) accession number: Q1CBX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3