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Q1CBX8

- MSRA_YERPA

UniProt

Q1CBX8 - MSRA_YERPA

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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521UniRule annotation

GO - Molecular functioni

  1. peptide-methionine (S)-S-oxide reductase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular protein modification process Source: UniProtKB-HAMAP
  2. protein repair Source: InterPro
  3. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciYPES360102:GHZU-83-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:YPA_0075
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001971: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Peptide methionine sulfoxide reductase MsrAPRO_1000068375Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360102.YPA_0075.

Structurei

3D structure databases

ProteinModelPortaliQ1CBX8.
SMRiQ1CBX8. Positions 5-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0225.
HOGENOMiHOG000263862.
KOiK07304.
OMAiYAGGQTP.
OrthoDBiEOG6091JX.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CBX8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNVDNTAVI DAANALPGRL TSIPVSPLHA VHGHSMTYIP EGMDLAFFAM
60 70 80 90 100
GCFWGAERLF WQQPGVYSTA AGYSGGHTPN PTYHEVCSGR TGHAEVVRVV
110 120 130 140 150
FDPAVISYQQ LLQIFWENHD PAQGMRQGGD VGTQYRSAIY VLTPEQEEQA
160 170 180 190 200
HKSRERFQQA MEKAGDQRVI TSEITVALPF YYAEDDHQQY LHKNPHGYCG
210
LGGIGVCLPP NV
Length:212
Mass (Da):23,434
Last modified:July 11, 2006 - v1
Checksum:i053AFEE64208A3B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG12044.1.
RefSeqiYP_649989.1. NC_008150.1.

Genome annotation databases

EnsemblBacteriaiABG12044; ABG12044; YPA_0075.
GeneIDi4120390.
KEGGiypa:YPA_0075.
PATRICi18578934. VBIYerPes1796_0320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG12044.1 .
RefSeqi YP_649989.1. NC_008150.1.

3D structure databases

ProteinModelPortali Q1CBX8.
SMRi Q1CBX8. Positions 5-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360102.YPA_0075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG12044 ; ABG12044 ; YPA_0075 .
GeneIDi 4120390.
KEGGi ypa:YPA_0075.
PATRICi 18578934. VBIYerPes1796_0320.

Phylogenomic databases

eggNOGi COG0225.
HOGENOMi HOG000263862.
KOi K07304.
OMAi YAGGQTP.
OrthoDBi EOG6091JX.

Enzyme and pathway databases

BioCyci YPES360102:GHZU-83-MONOMER.

Family and domain databases

Gene3Di 3.30.1060.10. 1 hit.
HAMAPi MF_01401. MsrA.
InterProi IPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view ]
PANTHERi PTHR10173. PTHR10173. 1 hit.
Pfami PF01625. PMSR. 1 hit.
[Graphical view ]
SUPFAMi SSF55068. SSF55068. 1 hit.
TIGRFAMsi TIGR00401. msrA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Antiqua.

Entry informationi

Entry nameiMSRA_YERPA
AccessioniPrimary (citable) accession number: Q1CBX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 11, 2006
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3