Q1CBX8 (MSRA_YERPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	YPA_0075

Organism

Yersinia pestis bv. Antiqua (strain Antiqua) [Complete proteome] [HAMAP]

Taxonomic identifier

360102 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pestis

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP-Rule MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP-Rule MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular_function	peptide-methionine (S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Peptide methionine sulfoxide reductase MsrA HAMAP-Rule MF_01401		PRO_1000068375
Sites
	Active site	52	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1CBX8 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 053AFEE64208A3B4	FASTA	212	23,434
	10 20 30 40 50 60 MQNVDNTAVI DAANALPGRL TSIPVSPLHA VHGHSMTYIP EGMDLAFFAM GCFWGAERLF 70 80 90 100 110 120 WQQPGVYSTA AGYSGGHTPN PTYHEVCSGR TGHAEVVRVV FDPAVISYQQ LLQIFWENHD 130 140 150 160 170 180 PAQGMRQGGD VGTQYRSAIY VLTPEQEEQA HKSRERFQQA MEKAGDQRVI TSEITVALPF 190 200 210 YYAEDDHQQY LHKNPHGYCG LGGIGVCLPP NV

References

[1]

"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen." Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L. J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Antiqua.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000308 Genomic DNA. Translation: ABG12044.1.
RefSeq	YP_649989.1. NC_008150.1.
3D structure databases
ProteinModelPortal	Q1CBX8.
SMR	Q1CBX8. Positions 5-210.
ModBase	Search...
Protein-protein interaction databases
STRING	360102.YPA_0075.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG12044; ABG12044; YPA_0075.
GeneID	4120390.
KEGG	ypa:YPA_0075.
PATRIC	18578934. VBIYerPes1796_0320.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HOG000263862.
KO	K07304.
OMA	SAIYCTT.
ProtClustDB	PRK00058.
Family and domain databases
Gene3D	3.30.1060.10. 1 hit.
HAMAP	MF_01401. MsrA.
InterPro	IPR002569. Met_Sox_Rdtase_MsrA. [Graphical view]
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_YERPA

Accession

Primary (citable) accession number: Q1CBX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program