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Q1CAS3 (MUTH_YERPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutH
Alternative name(s):
Methyl-directed mismatch repair protein
Gene names
Name:mutH
Ordered Locus Names:YPA_0481
OrganismYersinia pestis bv. Antiqua (strain Antiqua) [Complete proteome] [HAMAP]
Taxonomic identifier360102 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair By similarity. HAMAP-Rule MF_00759

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00759.

Sequence similarities

Belongs to the MutH family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA modification

Inferred from electronic annotation. Source: InterPro

DNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

endonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228DNA mismatch repair protein MutH HAMAP-Rule MF_00759
PRO_1000046719

Sequences

Sequence LengthMass (Da)Tools
Q1CAS3 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: B5B200BA62296443

FASTA22825,332
        10         20         30         40         50         60 
MSVYSLPPAP PSDEHQLFQR AQALSGFTLG ELATRAQWVI PADLKRVKGW VGMLLEFYLG 

        70         80         90        100        110        120 
ASAGSKPEQD FADIGIELKT IPISAQGKPL ETTFVCVAPL TGNSGVTWES SHVRHKLARV 

       130        140        150        160        170        180 
LWVPVEGERH IPLAERRVGA PLLWSPNVEE EELLRRDWEE LMDLIVLGKV ESITARHGQV 

       190        200        210        220 
LQLRPKAANS RALTEAIGEF GQPIMTLPRG FYLKKTLTAP MLARHFLL 

« Hide

References

[1]"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Antiqua.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000308 Genomic DNA. Translation: ABG12449.1.
RefSeqYP_650394.1. NC_008150.1.

3D structure databases

ProteinModelPortalQ1CAS3.
SMRQ1CAS3. Positions 9-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360102.YPA_0481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG12449; ABG12449; YPA_0481.
GeneID4119016.
KEGGypa:YPA_0481.
PATRIC18579895. VBIYerPes1796_0789.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3066.
HOGENOMHOG000271839.
KOK03573.
OMALRPKGAN.
OrthoDBEOG6CGCC0.

Enzyme and pathway databases

BioCycYPES360102:GHZU-502-MONOMER.

Family and domain databases

Gene3D3.40.600.10. 1 hit.
HAMAPMF_00759. MutH.
InterProIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamPF02976. MutH. 1 hit.
[Graphical view]
SMARTSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMSSF52980. SSF52980. 1 hit.
TIGRFAMsTIGR02248. mutH_TIGR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMUTH_YERPA
AccessionPrimary (citable) accession number: Q1CAS3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families