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Q1CAS3

- MUTH_YERPA

UniProt

Q1CAS3 - MUTH_YERPA

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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA modification Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciYPES360102:GHZU-502-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:YPA_0481
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001971: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228DNA mismatch repair protein MutHPRO_1000046719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360102.YPA_0481.

Structurei

3D structure databases

ProteinModelPortaliQ1CAS3.
SMRiQ1CAS3. Positions 9-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CAS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVYSLPPAP PSDEHQLFQR AQALSGFTLG ELATRAQWVI PADLKRVKGW
60 70 80 90 100
VGMLLEFYLG ASAGSKPEQD FADIGIELKT IPISAQGKPL ETTFVCVAPL
110 120 130 140 150
TGNSGVTWES SHVRHKLARV LWVPVEGERH IPLAERRVGA PLLWSPNVEE
160 170 180 190 200
EELLRRDWEE LMDLIVLGKV ESITARHGQV LQLRPKAANS RALTEAIGEF
210 220
GQPIMTLPRG FYLKKTLTAP MLARHFLL
Length:228
Mass (Da):25,332
Last modified:July 11, 2006 - v1
Checksum:iB5B200BA62296443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG12449.1.
RefSeqiYP_650394.1. NC_008150.1.

Genome annotation databases

EnsemblBacteriaiABG12449; ABG12449; YPA_0481.
GeneIDi4119016.
KEGGiypa:YPA_0481.
PATRICi18579895. VBIYerPes1796_0789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG12449.1 .
RefSeqi YP_650394.1. NC_008150.1.

3D structure databases

ProteinModelPortali Q1CAS3.
SMRi Q1CAS3. Positions 9-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360102.YPA_0481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG12449 ; ABG12449 ; YPA_0481 .
GeneIDi 4119016.
KEGGi ypa:YPA_0481.
PATRICi 18579895. VBIYerPes1796_0789.

Phylogenomic databases

eggNOGi COG3066.
HOGENOMi HOG000271839.
KOi K03573.
OMAi LRPKGAN.
OrthoDBi EOG6CGCC0.

Enzyme and pathway databases

BioCyci YPES360102:GHZU-502-MONOMER.

Family and domain databases

Gene3Di 3.40.600.10. 1 hit.
HAMAPi MF_00759. MutH.
InterProi IPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view ]
Pfami PF02976. MutH. 1 hit.
[Graphical view ]
SMARTi SM00927. MutH. 1 hit.
[Graphical view ]
SUPFAMi SSF52980. SSF52980. 1 hit.
TIGRFAMsi TIGR02248. mutH_TIGR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Antiqua.

Entry informationi

Entry nameiMUTH_YERPA
AccessioniPrimary (citable) accession number: Q1CAS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3