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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA modification Source: InterPro
  2. mismatch repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciYPES360102:GHZU-502-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:YPA_0481
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001971 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228DNA mismatch repair protein MutHPRO_1000046719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360102.YPA_0481.

Structurei

3D structure databases

ProteinModelPortaliQ1CAS3.
SMRiQ1CAS3. Positions 9-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CAS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYSLPPAP PSDEHQLFQR AQALSGFTLG ELATRAQWVI PADLKRVKGW
60 70 80 90 100
VGMLLEFYLG ASAGSKPEQD FADIGIELKT IPISAQGKPL ETTFVCVAPL
110 120 130 140 150
TGNSGVTWES SHVRHKLARV LWVPVEGERH IPLAERRVGA PLLWSPNVEE
160 170 180 190 200
EELLRRDWEE LMDLIVLGKV ESITARHGQV LQLRPKAANS RALTEAIGEF
210 220
GQPIMTLPRG FYLKKTLTAP MLARHFLL
Length:228
Mass (Da):25,332
Last modified:July 11, 2006 - v1
Checksum:iB5B200BA62296443
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG12449.1.
RefSeqiYP_650394.1. NC_008150.1.

Genome annotation databases

EnsemblBacteriaiABG12449; ABG12449; YPA_0481.
GeneIDi4119016.
KEGGiypa:YPA_0481.
PATRICi18579895. VBIYerPes1796_0789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG12449.1.
RefSeqiYP_650394.1. NC_008150.1.

3D structure databases

ProteinModelPortaliQ1CAS3.
SMRiQ1CAS3. Positions 9-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360102.YPA_0481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG12449; ABG12449; YPA_0481.
GeneIDi4119016.
KEGGiypa:YPA_0481.
PATRICi18579895. VBIYerPes1796_0789.

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Enzyme and pathway databases

BioCyciYPES360102:GHZU-502-MONOMER.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Antiqua.

Entry informationi

Entry nameiMUTH_YERPA
AccessioniPrimary (citable) accession number: Q1CAS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: February 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.