Q1CAS3 (MUTH_YERPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutH

Alternative name(s):
Methyl-directed mismatch repair protein

Gene names

Name:	mutH
Ordered Locus Names:	YPA_0481

Organism

Yersinia pestis bv. Antiqua (strain Antiqua) [Complete proteome] [HAMAP]

Taxonomic identifier

360102 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pestis

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair By similarity. HAMAP-Rule MF_00759
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MutH family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA modification Inferred from electronic annotation. Source: InterPro mismatch repair Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	DNA mismatch repair protein MutH HAMAP-Rule MF_00759		PRO_1000046719

Sequences

	Sequence		Length	Mass (Da)
	Q1CAS3 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: B5B200BA62296443	FASTA	228	25,332
	10 20 30 40 50 60 MSVYSLPPAP PSDEHQLFQR AQALSGFTLG ELATRAQWVI PADLKRVKGW VGMLLEFYLG 70 80 90 100 110 120 ASAGSKPEQD FADIGIELKT IPISAQGKPL ETTFVCVAPL TGNSGVTWES SHVRHKLARV 130 140 150 160 170 180 LWVPVEGERH IPLAERRVGA PLLWSPNVEE EELLRRDWEE LMDLIVLGKV ESITARHGQV 190 200 210 220 LQLRPKAANS RALTEAIGEF GQPIMTLPRG FYLKKTLTAP MLARHFLL

References

[1]

"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen." Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L. J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Antiqua.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000308 Genomic DNA. Translation: ABG12449.1.
RefSeq	YP_650394.1. NC_008150.1.
3D structure databases
ProteinModelPortal	Q1CAS3.
SMR	Q1CAS3. Positions 9-228.
ModBase	Search...
Protein-protein interaction databases
STRING	360102.YPA_0481.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG12449; ABG12449; YPA_0481.
GeneID	4119016.
KEGG	ypa:YPA_0481.
PATRIC	18579895. VBIYerPes1796_0789.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3066.
HOGENOM	HOG000271839.
KO	K03573.
OMA	LRPKGAN.
ProtClustDB	PRK05070.
Family and domain databases
Gene3D	3.40.600.10. 1 hit.
HAMAP	MF_00759. MutH.
InterPro	IPR004230. DNA_mismatch_repair_MutH. IPR011337. DNA_rep_MutH/RE_typeII. IPR011335. Restrct_endonuc-II-like. [Graphical view]
Pfam	PF02976. MutH. 1 hit. [Graphical view]
SMART	SM00927. MutH. 1 hit. [Graphical view]
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit.
TIGRFAMs	TIGR02248. mutH_TIGR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MUTH_YERPA

Accession

Primary (citable) accession number: Q1CAS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program