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Q1CAS3

- MUTH_YERPA

UniProt

Q1CAS3 - MUTH_YERPA

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Protein

DNA mismatch repair protein MutH

Gene
mutH, YPA_0481
Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair By similarity.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA modification Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciYPES360102:GHZU-502-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutH
Alternative name(s):
Methyl-directed mismatch repair protein
Gene namesi
Name:mutH
Ordered Locus Names:YPA_0481
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001971: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228DNA mismatch repair protein MutHUniRule annotationPRO_1000046719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360102.YPA_0481.

Structurei

3D structure databases

ProteinModelPortaliQ1CAS3.
SMRiQ1CAS3. Positions 9-228.

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CAS3-1 [UniParc]FASTAAdd to Basket

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MSVYSLPPAP PSDEHQLFQR AQALSGFTLG ELATRAQWVI PADLKRVKGW    50
VGMLLEFYLG ASAGSKPEQD FADIGIELKT IPISAQGKPL ETTFVCVAPL 100
TGNSGVTWES SHVRHKLARV LWVPVEGERH IPLAERRVGA PLLWSPNVEE 150
EELLRRDWEE LMDLIVLGKV ESITARHGQV LQLRPKAANS RALTEAIGEF 200
GQPIMTLPRG FYLKKTLTAP MLARHFLL 228
Length:228
Mass (Da):25,332
Last modified:July 11, 2006 - v1
Checksum:iB5B200BA62296443
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000308 Genomic DNA. Translation: ABG12449.1.
RefSeqiYP_650394.1. NC_008150.1.

Genome annotation databases

EnsemblBacteriaiABG12449; ABG12449; YPA_0481.
GeneIDi4119016.
KEGGiypa:YPA_0481.
PATRICi18579895. VBIYerPes1796_0789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000308 Genomic DNA. Translation: ABG12449.1 .
RefSeqi YP_650394.1. NC_008150.1.

3D structure databases

ProteinModelPortali Q1CAS3.
SMRi Q1CAS3. Positions 9-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360102.YPA_0481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG12449 ; ABG12449 ; YPA_0481 .
GeneIDi 4119016.
KEGGi ypa:YPA_0481.
PATRICi 18579895. VBIYerPes1796_0789.

Phylogenomic databases

eggNOGi COG3066.
HOGENOMi HOG000271839.
KOi K03573.
OMAi LRPKGAN.
OrthoDBi EOG6CGCC0.

Enzyme and pathway databases

BioCyci YPES360102:GHZU-502-MONOMER.

Family and domain databases

Gene3Di 3.40.600.10. 1 hit.
HAMAPi MF_00759. MutH.
InterProi IPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view ]
Pfami PF02976. MutH. 1 hit.
[Graphical view ]
SMARTi SM00927. MutH. 1 hit.
[Graphical view ]
SUPFAMi SSF52980. SSF52980. 1 hit.
TIGRFAMsi TIGR02248. mutH_TIGR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Antiqua.

Entry informationi

Entry nameiMUTH_YERPA
AccessioniPrimary (citable) accession number: Q1CAS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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