Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:YPA_0686
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000001971 Componenti: Chromosome

Subcellular locationi

Q1CA68:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 159HelicalUniRule annotationAdd BLAST23
Transmembranei164 – 186HelicalUniRule annotationAdd BLAST23
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21
Transmembranei275 – 295HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_50001158221 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1CA68.
SMRiQ1CA68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 310ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiSPLMEFL.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1CA68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNDKDLSTW QTFRRLWPTI SPYKAGLIVA AIALILNAAS DTFMLSLLKP
60 70 80 90 100
LLDDGFGNSN SSILKWMPLA VIGLMVVRGV TGFVSSYCIS WVSGKVVMHI
110 120 130 140 150
RRRLFSHMMG MPVSFFDQQS TGTLLSRITY DSEQVAASSS SALVTVVREG
160 170 180 190 200
ASIIGLFIMM FYYSWQLSLI LIVIAPIVSI SIRLVSKRFR NISKNMQNTM
210 220 230 240 250
GEVTTSAEQM LKGHKEVLIF GGQKVETERF DAVSNRMRQQ GMKLVSASSI
260 270 280 290 300
SDPIIQLIAS FALALVLYAA SFPSVMETLT AGTITVVFSA MIALMRPLKS
310 320 330 340 350
LTNVNTQFQR GMAACQTLFS ILDMEQEKDE GKLEVERAKG DIEFRHVTFY
360 370 380 390 400
YPGKDTPALN DINIHLEAGK TVALVGRSGS GKSTIANLLT RFYDVSEGSI
410 420 430 440 450
LLDGHDLRDY RLGALRNQVA LVSQNVHLFN DTVANNIAYA RNEQYSRAEI
460 470 480 490 500
EEAARMAYAM DFINKMEHGL DTVIGENGIM LSGGQRQRIA IARALLRNCP
510 520 530 540 550
ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS TIEKADEIVV
560 570 580
IEDGRIVERG VHAELLVQQG VYAQLNRMQF GQ
Length:582
Mass (Da):64,462
Last modified:July 11, 2006 - v1
Checksum:i12FA0E34D64D2C6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG12654.1.
RefSeqiWP_002211320.1. NZ_CP009906.1.

Genome annotation databases

EnsemblBacteriaiABG12654; ABG12654; YPA_0686.
KEGGiypa:YPA_0686.

Similar proteinsi

Entry informationi

Entry nameiMSBA_YERPA
AccessioniPrimary (citable) accession number: Q1CA68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 11, 2006
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families