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Reviewed, UniProtKB/Swiss-Prot Q1C9P0 (LLDD_YERPA)

Last modified November 25, 2008. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3
Gene names
Name: lldD
Ordered Locus Names: YPA_0864
OrganismYersinia pestis bv. Antiqua (strain Antiqua) [Complete proteome] [HAMAP]
Taxonomic identifier360102 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

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Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).

Cofactor

FMN By similarity.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

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Ontologies

Keywords

   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: HAMAP

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381L-lactate dehydrogenase [cytochrome]
PRO_1000068997

Regions

Domain1 – 380380FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
Q1C9P0-1 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: ECC708A08D5E4634

FASTA38141,259
        10         20         30         40         50         60 
MIISASTDYR AAAQRKLPPF LFHYIDGGAY NEQTLRRNTA DLADIALRQR VLKNMSELSL 

        70         80         90        100        110        120 
ETQLFGETQA MPVVLGPVGL SGMYARRGEV QAARAADKKG IPFTLSTLSV CPIEEVAPAI 

       130        140        150        160        170        180 
ARPMWFQLYV LKDRGFMRNA LTRAQAAGVK TLVFTVDMPV PGARYRDAHS GMSGPNAAAR 

       190        200        210        220        230        240 
RLLQAIAHPQ WAWDVGLNGK PHDLGNISAY LGKPTTLEDY MGWIATNFDP SISWKDLEWV 

       250        260        270        280        290        300 
REFWQGPMII KGILDPEDAK DAVKFGADGI VVSNHGGRQL DGVLSTARAL PAIADAVKGD 

       310        320        330        340        350        360 
ITILADSGIR TGLDVVRMIA LGADSVLLGR AFVYALATAG EAGVINLLTL IEQEMRVAMT 

       370        380 
LTGAKRIADI NRDSLAVSER G

« Hide

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References

[1]"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
J. Bacteriol. 188:4453-4463(2006) [PubMed: 16740952] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000308 Genomic DNA. Translation: ABG12832.1.
RefSeqYP_650777.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4120792.
GenomeReviewsGene locus YPA_0864 in contig CP000308_GR.
KEGGypa:YPA_0864.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ1C9P0.

Enzyme and pathway databases

BioCycYPES360102:YPA_0864-MON.

Family and domain databases

HAMAPMF_01559.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha_OHA_DHase_FMN.
IPR008259. FMN_hydac_DHase_AS.
IPR000262. FMN_OHA_DHase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLLDD_YERPA
AccessionPrimary (citable) accession number: Q1C9P0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 11, 2006
Last modified: November 25, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents